Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice

Himmerich, Hubertus; Treasure, Janet

doi:10.1016/j.molmed.2024.01.002

Cited by 7 publications

(1 citation statement)

References 58 publications

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“…It has been well-documented that eating disorders such as AN and BN interact with a range of mental and organic disorders ( AlHadi et al, 2022 ). Blocking the progression of AN and BN by modulating the gut microbiota and its metabolites has received widespread attention from clinical researchers ( Jiao et al, 2023 ; Himmerich and Treasure, 2024 ). However, the ethical dilemma and compliance problems in adolescent treatment add additional challenges to clinical research ( Frostad and Bentz, 2022 ; Tsiandoulas et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Yu,

Guo,

et al. 2024

Front. Microbiol.

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BackgroundAnorexia nervosa (AN) and bulimia nervosa (BN) poses a significant challenge to global public health. Despite extensive research, conclusive evidence regarding the association between gut microbes and the risk of AN and BN remains elusive. Mendelian randomization (MR) methods offer a promising avenue for elucidating potential causal relationships.Materials and methodsGenome-wide association studies (GWAS) datasets of AN and BN were retrieved from the OpenGWAS database for analysis. Independent single nucleotide polymorphisms closely associated with 196 gut bacterial taxa from the MiBioGen consortium were identified as instrumental variables. MR analysis was conducted utilizing R software, with outlier exclusion performed using the MR-PRESSO method. Causal effect estimation was undertaken employing four methods, including Inverse variance weighted. Sensitivity analysis, heterogeneity analysis, horizontal multivariate analysis, and assessment of causal directionality were carried out to assess the robustness of the findings.ResultsA total of 196 bacterial taxa spanning six taxonomic levels were subjected to analysis. Nine taxa demonstrating potential causal relationships with AN were identified. Among these, five taxa, including Peptostreptococcaceae, were implicated as exerting a causal effect on AN risk, while four taxa, including Gammaproteobacteria, were associated with a reduced risk of AN. Similarly, nine taxa exhibiting potential causal relationships with BN were identified. Of these, six taxa, including Clostridiales, were identified as risk factors for increased BN risk, while three taxa, including Oxalobacteraceae, were deemed protective factors. Lachnospiraceae emerged as a common influence on both AN and BN, albeit with opposing effects. No evidence of heterogeneity or horizontal pleiotropy was detected for significant estimates.ConclusionThrough MR analysis, we revealed the potential causal role of 18 intestinal bacterial taxa in AN and BN, including Lachnospiraceae. It provides new insights into the mechanistic basis and intervention targets of gut microbiota-mediated AN and BN.

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Section: Discussionmentioning

confidence: 99%

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Yu,

Guo,

et al. 2024

Front. Microbiol.

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Editorial: Biological Therapies and Eating Disorders

Himmerich,

Herpertz‐Dahlmann,

Mörkl

2024

Euro Eating Disorders Rev

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ObjectiveBlood‐based biomarkers and neuroimaging techniques have improved our understanding of the underlying biology of eating disorders (EDs) and have increased our diagnostic portfolio.MethodThis editorial accompanies an article collection on novel biological approaches to treat EDs.ResultsThe collection covers intermittent theta burst stimulation, therapeutic drug monitoring, pharmacological treatments (olanzapine, metreleptin, psychedelics, and anti‐inflammatory medications), microbiome‐based treatments such as pro‐ and prebiotics, as well as individually tailored treatment approaches for EDs.DiscussionResearch of brain areas and bodily systems that are related to memory, emotions and immune function will hopefully expand the biological treatment options for people with EDs.

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C-reactive protein (CRP) levels in people with eating disorders: A systematic review and meta-analysis

Xu,

Mutwalli,

Haslam

et al. 2024

Journal of Psychiatric Research

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Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice

Cited by 7 publications

References 58 publications

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Editorial: Biological Therapies and Eating Disorders

C-reactive protein (CRP) levels in people with eating disorders: A systematic review and meta-analysis

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