Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Mascitti, Marco; Coccia, Erminia; Vignini, Arianna; Aquilanti, Luca; Santarelli, Andrea; Salvolini, Eleonora; Mazzanti, Laura; Procaccini, Maurizio; Rappelli, Giorgio

doi:10.3390/dj7020060

Cited by 8 publications

(17 citation statements)

References 52 publications

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“…In animal models, increased epithelial tissue SOD activity relative to the control group was found after anticonvulsant drug treatment (Wu et al, 2018), a kind of drug used by this group. Nutritional alterations resulted in chewing problems and dysphagia in MC groups; they may also be involved in the greater SOD activity observed in saliva, similarly to what has already been described with nutritional problems resulting from anorexia (Mascitti et al, 2019). When SOD was expressed in relation of total protein (U/mg) these increased of activity is not observed, because protein total is higher in saliva of the MC group than NC group.…”

Section: Discussionsupporting

confidence: 65%

Alteration on redox status in saliva of microcephaly children

Alves

Barbieri

Gomes

et al. 2021

RSD

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Microcephaly is described as a reduction of the head circumference, due to the premature fusion of the bones of the skull, preventing the brain from growing normally and reaching its maximum development. This condition may result in neurological disorders, phonation and chewing dysfunction, dysphagia and risk of malnutrition. This alteration contributes to oral hygiene impairment, and continuous uses of the antipsychotic and anticonvulsant medication. Thus, the purpose of this study was to evaluate if microcephaly modified redox balance in saliva. Our hypothesis is that in the microcephalic patient's salivary oxidative stress is lower because of the increase in antioxidant defenses. The study included 13 patients with microcephaly (microcephalic group – MC) and 12 patients without neurological disorders (normocephalic group – NC), from zero to ten years old, no edentulous. Saliva was collected using a cotton wool swab, placing it on the child's mouth floor. After centrifugation, supernatants were fractionated and stored at -80 °C for analyses. Lipid oxidative was evaluated by TBARS methods, total antioxidant capacity by the ferric reducing ability (FRAP) assay, uric acid (UA) was quantified by modified Trinder reaction, and superoxide dismutase activity (SOD) by inhibition of the pyrogallol auto-oxidation. Total protein was measured using the method of Lowry. Compared to NC group, TBARS was significantly lower in MC group, while FRAP, UA and SOD were higher. Our hypothesis was confirmed. MC patients have lower salivary oxidative stress, due to increased oxidant defenses.

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Section: Discussionsupporting

confidence: 65%

Alteration on redox status in saliva of microcephaly children

Alves

Barbieri

Gomes

et al. 2021

RSD

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“…This enzyme is capable of increasing in response to different inflammatory diseases such as pulpitis and periodontitis. SOD is able to protect the oral cavity against the effects of ROS, which could be considered a partial compensatory response when there is oxidative stress in the cavity, and SOD represents the first defense in the antioxidant tissues [44,45].…”

Section: Discussionmentioning

confidence: 99%

Mouthwash with Tagetes lucida Cav. for Control of Chronic Periodontitis in Older Adults

et al. 2021

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Background: Tagetes lucida Cav (T. lucida) is an herbaceous plant from the family Asteraceae, native to Mexico, Guatemala, and other Mesoamerican countries. Their common names are: (i) Spanish names: “hierbanís”, “jericón”, “pericón vomol”, “Santa María”, “cuchrucumín”, “falso hipericón”, “hierba añil”, “pericón”, “periquillo”; (ii) indigenous names: “ichka”, “cuahuyauhtli”, “yahuhtli”, “naná uarhi”, and (iii) English names: “sweet-scented marigold”, “sweet mace”, and “sweet marigold”., Its chemical composition of coumarins, estragole, quercetin, and flavonoids has antioxidant, anti-inflammatory, and antimicrobial effects. This study aimed to evaluate the effect of a mouthwash made with T. lucida for control of chronic periodontitis (CP) in older adults. Methods: We carried out a quasi-experimental study with a convenience sample of 60 older adults with CP. The sample was divided into a placebo group (PG) n = 30, administered with a mouthwash made with alcohol diluted with purified water (10%), and the experimental group (EG) n = 30 treated with a mouthwash made with T. lucida extract in 10% alcohol; both groups were administered three times a day for three months. Results: We found a significant improvement in the EG group compared with the PG group in: probing pocket depth (baseline, 5.2 ± 0.81 vs. post-treatment, 3.1 ± 0.43, p < 0.05), the clinical attachment loss (baseline, 6.6 ± 1.9 vs. post-treatment, 2.1 ± 1.5, p < 0.05), lipoperoxides (baseline, 0.056 ± 0.03 vs. post-treatment, 0.034 ± 0.02 µmol/L, p < 0.05), and chronic inflammation markers (IL-1, IL-8, and TNF-α) (p < 0.05). Conclusions: Our findings suggest that mouthwash made with T. lucida extract, administered three times a day, clinically improved chronic periodontitis in older adults, associated to a significant decrease in lipoperoxides and proinflammatory markers.

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“…Panico et al (2018) [60] and Lesar et al (2022) [61] observed oral lesions in up to 94% of patients. Their locations can be on the lips, which are dry in as many as 76.2% [62], 93.2% [52], or 69% [28] of subjects. In addition, exfoliative cheilitis, angular cheilitis, and labial erythema are very frequently diagnosed [1,52,53,60,61,63].…”

Section: Oral Mucosal Healthmentioning

confidence: 99%

Diet Traps during Eating Disorders among Dentate Patients at an Oral Health Glance

Paszynska,

Hernik,

Rangé

et al. 2023

Nutrients

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Persons suffering from eating disorders (ED) may often experience a recurrence/persistence symptoms despite the completion of psychiatric therapy. In most cases, their general health status is linked to current nutritional behaviors. Medical professionals, general practitioners (GPs), dieticians, and dentists may see those patients in their practices. At the same time, due to low sense of illness, some patients may delay or never seek professional medical care. The aim of this article is to analyze the main ED types according to dietary behaviors causing oral health problems and discuss oral health complications in affected dentate patients. The second objective is to update oral preventive measures and technological innovations together with active agents for oral hygiene care that might effectively support oral health maintenance during the presence of long-term symptoms. The research method involved a review of clinical reports as a synthesis of the electronic research in the Pubmed, Web of Science, and Google Scholar databases. Based on the research, ED patients were found to present related incidences of oral complications. Studies have reported that the possible course of an ED and comorbidities may be an imbalance in the oral environment. The results showed an association between biological (malnutrition, etc.), behavioral (binge eating episodes, vomiting, acidic diet, poor oral hygiene), and pharmacotherapeutic (addiction, hyposalivation) factors that may threaten oral health. Early diagnosis of the past and present symptoms is essential to eliminate and take control of destructive behaviors. Oral changes need to be tackled with medical insight, and additionally, the perception of dietary interactions is recommended.

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Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Cited by 8 publications

References 52 publications

Alteration on redox status in saliva of microcephaly children

Alteration on redox status in saliva of microcephaly children

Mouthwash with Tagetes lucida Cav. for Control of Chronic Periodontitis in Older Adults

Diet Traps during Eating Disorders among Dentate Patients at an Oral Health Glance

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