Anorexie mentale : anomalies des paramètres hématologiques et biochimiques

Lemille, J.; Bras, M. Le; Fauconnier, M.; Grall‐Bronnec, Marie

doi:10.1016/j.revmed.2020.12.010

Cited by 4 publications

(4 citation statements)

References 60 publications

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“…Research on adolescents suggested ANO induced damage to liver function as a potential cause for hypercholesterolemia and reduced clearance rates of many steroid hormones [ 46 ]. Moreover, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis during fasting in ANO patients can lead to increaseD plasma cortisol levels [ 47 ]. Changes in these factors may alter metabolic levels and heighten the risk of MetS.…”

Section: Discussionmentioning

confidence: 99%

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study

Gao,

Qin,

Jiao

et al. 2024

Transl Psychiatry

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Emerging evidence reveals associations between metabolic syndrome (MetS) and psychiatric disorders (PDs), although causality remains uncertain. Consequently, we conducted Mendelian randomization (MR) to systematically evaluate the causality between MetS and PDs. Linkage disequilibrium score regression estimated the heritability of PDs and their genetic correlations with MetS. In primary analyses, the main model employed inverse variance weighting method, with sensitivity analyses using various MR models to ensure robustness. Replication MR analyses, involving cohorts distinct from those in the primary analyses, were performed to validate the generalizability of the findings. Multivariable MR analyses were carried out to account for genetically predicted body mass index (BMI). As a result, genetic correlations of MetS with attention-deficit/hyperactivity disorder(ADHD), anorexia nervosa(ANO), major depressive disorder(MDD), and schizophrenia were identified. Causal effects of MetS on ADHD (OR: 1.59 [95% CI:1.45–1.74]), ANO (OR: 1.42 [95% CI:1.25–1.61]), MDD(OR: 1.23 [95% CI: 1.13–1.33]), and the effects of ADHD (OR: 1.03 [95% CI: 1.02–1.04]) and ANO (OR: 1.01 [95% CI: 1.01–1.02]) on MetS were observed in primary analyses. Results from sensitivity analyses and replication analyses were generally consistent with the primary analyses, confirming the robustness and generalizability of the findings. Associations between MetS and ADHD, as well as ANO persisted after adjusting for BMI, whereas the statistical significance of the association between MetS and MDD was no longer observable. These results contribute to a deeper understanding of the mechanisms underlying PDs, suggesting potential modifiable targets for public prevention and clinical intervention in specific PDs related to metabolic pathways.

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Section: Discussionmentioning

confidence: 99%

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study

Gao,

Qin,

Jiao

et al. 2024

Transl Psychiatry

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“…Les troubles somatiques liés à la dénutrition sont fréquents. Il s'agit le plus souvent d'atteintes modérées et réversibles sous réserve d'une réhabilitation nutritionnelle et pondérale adaptée [5]. En cas de chronicisation des TCA, les conséquences physiques s'aggravent : oedèmes de carence, amyotrophie, ostéoporose, troubles circulatoires, cardiaques, digestifs, rénaux, métaboliques, infectieux, cutanés, dentaires, gynécologiques (infertilité).…”

Section: Les Conséquences Physiquesunclassified

“…Le risque majeur est une défaillance multiviscérale. Une renutrition progressive et par alimentation entérale est dans ce cas nécessaire [5].…”

Section: Les Conséquences Physiquesunclassified

Les soins dans l’anorexie mentale : la nécessaire synthèse des soins psychiques et somatiques

Rocher¹,

Bras²

2022

l'Information Psychiatrique

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La prise en charge des troubles du comportement alimentaire (TCA) et notamment de l'anorexie mentale dans des formes sévères nécessitant une renutrition entérale est un temps de soin délicat. Fort d'une expérience de collaboration de plus de 40 ans entre les services d'addictologie et d'endocrinologie-nutrition, nous avons souhaité décrire nos pratiques aux différents temps de soin en insistant sur la synergie et l'intérêt pour la patiente et son entourage de cette articulation de liaison.

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“… 7 At present, there are no reports on the epidemiology of adolescents with AN in China. Without effective treatment, AN could lead to multiple system dysfunction, such as bradycardia, 8 , 9 hypoglycaemia, 10 electrolyte disorders, 11 osteoporosis, 12 haematopoiesis abnormality 13 and acute liver failure. 14 The standardized mortality ratio of AN inpatients with the complications of severe malnutrition was found to be as high as 15.9.…”

Section: Introductionmentioning

confidence: 99%

Acute liver failure and aplastic crisis due to anorexia nervosa in an adolescent girl: a case report

Chen,

Liu,

Zheng

2023

J Int Med Res

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Anorexia nervosa (AN) has a high mortality rate due to the widespread organ dysfunction caused by the underlying severe malnutrition. Malnutrition-induced hepatitis is common among individuals with AN especially as body mass index decreases, while acute liver failure and aplastic crisis related to coagulation disease and encephalopathy rarely occur in AN patients. The supervised increase of caloric intake can quickly improve the elevated aminotransferases caused by starvation and aplastic crisis. This current case report describes a 12-year-old adolescent girl who was admitted with a 3-month history of weight loss. Within 3 months, she had lost 10 kg of weight. The girl was diagnosed with AN, acute liver failure, severe malnutrition with emaciation, electrolyte disorder, bradycardia and aplastic crisis. She was gradually supplemented with vitamins and enteral nutrition to avoid refeeding syndrome. After treatment, her liver function and haematopoietic function returned to normal. In conclusion, acute liver failure and aplastic crisis are rare but potentially life-threatening complications of AN, which could be improved by supervised feeding and timely rehydration. AN should be considered as the potential aetiology of acute liver failure and aplastic crisis.

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Anorexie mentale : anomalies des paramètres hématologiques et biochimiques

Cited by 4 publications

References 60 publications

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study

Les soins dans l’anorexie mentale : la nécessaire synthèse des soins psychiques et somatiques

Acute liver failure and aplastic crisis due to anorexia nervosa in an adolescent girl: a case report

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