Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice

Chioca, Lea Rosa; Antunes, Valquíria D.; Ferro, Marcelo Machado; Losso, Estela Maris; Andreatini, Roberto

doi:10.1016/j.lfs.2013.03.012

Cited by 45 publications

(30 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anxiolytic effect of pure linalool (Umezu and others ) and its derivative linalool oxide (Souto‐Maior and others ) was verified in a small number of studies in rats. Greater attention was paid to these properties in lavender essential oils, where linalool and other terpene alcohols are major components (Bradley and others , ; Chioca and others ) than in a commercial lavender preparation, Silexan (Woelk and Schlafke ; Kasper and others ).…”

Section: Sedative Effectsmentioning

confidence: 99%

Biologically Active Compounds from Hops and Prospects for Their Use

Karabín

Hudcová

Jelínek

et al. 2016

Comp Rev Food Sci Food Safe

200

181

View full text Add to dashboard Cite

Although female cones of the hop plant (Humulus lupulus) are known primarily as raw material supplying characteristic bitterness and aroma to beer, their equally significant health-promoting effects have been known to mankind for several thousand years and hop is a plant traditionally utilized in folk medicine. This paper summarizes the scientific knowledge on the effects of all 3 major groups of secondary metabolites of hops; polyphenols, essential oils, and resins. Because of their chemical diversity, it is no coincidence that these compounds exhibit a wide range of pharmacologically important properties. In addition to antioxidant, anti-inflammatory, and anticancer-related properties, particular attention is being paid to prenylflavonoids that occur almost exclusively in hops and are considered to be some of the most active phytoestrogens known. Hop oils and resins are well known for their sedative and other neuropharmacological properties, but in addition, these compounds exhibit antibacterial and antifungal effects. Recently, alpha bitter acids have been shown to block the development of a number of complex lifestyle diseases that are referred to by the collective name "metabolic syndrome." Information presented in this review confirms the significant potential for the use of hops in the pharmaceutical industry and provides an understanding of beer as a natural drink that, although moderately consumed, may become a source of many health-promoting compounds.

show abstract

Section: Sedative Effectsmentioning

confidence: 99%

Biologically Active Compounds from Hops and Prospects for Their Use

Karabín

Hudcová

Jelínek

et al. 2016

Comp Rev Food Sci Food Safe

200

181

View full text Add to dashboard Cite

show abstract

“…The inhalation procedure described by Chioca, Antunes, Ferro, Losso, and Andreatini () and Chioca, Ferro, et al () was used. Briefly, the mice were kept for 15 min in a plastic recipient with lid (32 × 24 × 32 cm) exposed to different concentrations of the C. sinensis essential oil (1%, 2.5%, 5%, and 10%), in a volume of 1 ml soaked in cotton wool, which was previously weighed (0.7 g).…”

Section: Methodsmentioning

confidence: 99%

The nitrergic neurotransmission contributes to the anxiolytic‐like effect of Citrus sinensis essential oil in animal models

Hocayen

Wendler

Vecchia

et al. 2019

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Citrus fragrances have been used in aromatherapy for the treatment of anxiety, and the essential oil of Citrus sinensis (sweet orange) has shown promising results, although its mechanism of action was not known. The objective of this study was to evaluate the involvement of nitric oxide (NO) neurotransmission in the anxiolytic-like effect of C. sinensis essential oil. Swiss male mice were submitted to 15 min of C. sinensis essential oil inhalation (1%, 2.5%, 5%, and 10%) and tested in the marble-burying test, neophobia-induced hypophagia, and light/dark test. Locomotor activity was evaluated in an automated locomotor activity box. The coadministration of C. sinensis essential oil with L-arginine (200 mg/kg, i.p.), an NO precursor, was used for the behavioral evaluation of nitrergic system mediation. Additionally, the NO synthase activity was measured by nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) analysis in the cerebral cortex. C. sinensis essential oil exerted anxiolytic-like effect at dose that did not change locomotor activity. Moreover, L-arginine pretreatment prevented this anxiolytic-like effect on marble-burying test. Finally, C. sinensis essential oil reduced the NADPH-d positive cells. Thus, the nitrergic neurotransmission plays a relevant role in the anxiolytic-like effect C. sinensis essential oil.

show abstract

“…[1][2][3][4][5][6] We recently found that in vivo transferability by inhalation administration varies depending on the type of volatile compounds. It has been reported that essential oils of coniferous trees, juniper, lavender and sandalwood have anxiolytic-like activities, and the chemical components exhibiting these effects are reported to be linalool, linalyl acetate, a-pinene and a-santalo.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that essential oils of coniferous trees, juniper, lavender and sandalwood have anxiolytic-like activities, and the chemical components exhibiting these effects are reported to be linalool, linalyl acetate, a-pinene and a-santalo. [1][2][3][4][5][6] We recently found that in vivo transferability by inhalation administration varies depending on the type of volatile compounds. 7 For example, 1,8-cineole is not readily metabolized from within the brain, even at 30 min after inhalation.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic‐like effects of essential oil from Thymus vulgaris was increased during stress

Satou

Hayakawa

Goto

et al. 2018

Flavour & Fragrance J

View full text Add to dashboard Cite

There is known to be a close relationship among anxiety, fatigue and stress. Here, we studied the anxiolytic‐like effects of essential oil from Thymus vulgaris (EOT), while focusing on the relationship with stress. Male ICR mice inhaled (i.h.) EOT for 90 min. Mice were placed under three different conditions; isolated, intraperitoneal (i.p.) administration of saline or polyinosinic‐polycytidylic acid (poly I:C). EOT did not show any significant anxiolytic‐like effects in isolated mice. On the other hand, in brain fatigue model mice by poly I:C, EOT showed significant anxiolytic‐like effects. EOT increased the absolute value in the elevated plus maze (EPM) tests in the brain fatigue model mice, while linalool and terpinen‐4‐ol in the brain with poly I:C were elevated when compared with isolated mice. Augmented concentrations of these components in the brain were also observed in mice with saline, i.p. These results suggest that the amount of volatile compounds transferred to the brain increased due to stress or inflammation. In the future, further investigation concerning the relationship between the blood brain barrier (BBB) and respiration is required.

show abstract

Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice

Abstract: These results suggest that olfactory system activation is unlikely to participate in the anxiolytic-like effect of lavender essential oil inhalation.

Cited by 45 publications

References 34 publications

Biologically Active Compounds from Hops and Prospects for Their Use

Biologically Active Compounds from Hops and Prospects for Their Use

The nitrergic neurotransmission contributes to the anxiolytic‐like effect of Citrus sinensis essential oil in animal models

Anxiolytic‐like effects of essential oil from Thymus vulgaris was increased during stress

Contact Info

Product

Resources

About