Anosmia is very common in the Lewy body variant of Alzheimer's disease

Olichney, John; Murphy, Claire; Hofstetter, C. Richard; Foster, Katharine; Hansen, Lawrence A.; Thal, Leon J.; Katzman, Robert

doi:10.1136/jnnp.2003.032003

Cited by 108 publications

(80 citation statements)

References 34 publications

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“…Previous studies using olfactory tests revealed that olfactory dysfunction is more common and marked in DLB than in AD [12,13]. In the present study, approximately 40% of DLB patients had anosmia or hyposmia at the onset of memory loss, while almost none of the AD patients and normal controls did.…”

Section: Discussionmentioning

confidence: 51%

Retrospective Survey of Prodromal Symptoms in Dementia with Lewy Bodies: Comparison with Alzheimer’s Disease

Chiba

Fujishiro²,

Iseki³

et al. 2012

Dement Geriatr Cogn Disord

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Background: Non-motor symptoms are recognized to enable the early detection of Parkinson’s disease (PD). It remains unknown when those symptoms appear in dementia with Lewy bodies (DLB). Method: We investigated the prevalence of 15 non-motor symptoms of PD at the onset of memory loss based on a standardized worksheet in 34 patients with DLB, 32 patients with Alzheimer’s disease (AD) and 30 normal controls. Results: DLB patients exhibited a significantly higher prevalence of olfactory dysfunction, constipation, increased saliva and signs of rapid eye movement sleep behavior disorder at the onset of memory loss than AD patients and normal controls. Conclusions: Paying attention to non-motor symptoms of PD may help DLB diagnosis in the early stage, especially in terms of its differentiation from AD.

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Section: Discussionmentioning

confidence: 51%

Retrospective Survey of Prodromal Symptoms in Dementia with Lewy Bodies: Comparison with Alzheimer’s Disease

Chiba

Fujishiro²,

Iseki³

et al. 2012

Dement Geriatr Cogn Disord

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“…While olfactory dysfunction has been demonstrated in AD, patients with Lewy body dementia have even greater impairments in olfaction, lending significance to the role of Lewy pathology in olfactory dysfunction [42][43][44] . Based on this assumption, it would be expected that nondegenerative causes of parkinsonism have intact olfaction, as is the case in vascular parkinsonism [45] and MPTP-induced parkinsonism [46] .…”

Section: Olfactory Loss As a Biomarker Of Pdmentioning

confidence: 99%

Olfactory Dysfunction in Parkinson’s Disease

Kranick

Duda²

2007

Neurosignals

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Prior to the onset of the cardinal motor features of idiopathic Parkinson‘s disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be good candidates for new neuroprotective strategies. As shown by the Braak neuropathologic staging of PD, the olfactory system is among the first neuronal populations to display Lewy body pathology. Clinically, loss of smell can be easily tested in the office using several validated techniques and is often helpful to the physician in distinguishing idiopathic PD from other forms of parkinsonism. Recent findings have indicated that a decline in olfaction may be observed in selected at-risk patients, which has significant implications for identifying potential study populations. Ongoing studies of olfactory dysfunction may also reveal potential for use as a medication-independent biomarker of disease progression in addition to use as a biomarker for the diagnosis of PD.

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“…Olfactory loss may also be an important preclinical marker of dementia, especially DLB (Olichney et al, 2005) and Alzheimer's disease. A major advantage of olfactory tests is that they are inexpensive and non-invasive.…”

Section: Olfactionmentioning

confidence: 99%