Anosognosia for memory deficit in amnestic mild cognitive impairment and Alzheimer's disease

Galeone, Filomena; Pappalardo, Stella; Chieffi, Sergio; Iavarone, Alessandro; Carlomagno, Sergio

doi:10.1002/gps.2583

Cited by 94 publications

(94 citation statements)

References 36 publications

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“…The finding that the QoL reported by patients with MCI was better than the opinion of their informants is probably better explained by MCI patients being less aware of their cognitive and functional decline. In fact, some degree of anosognosia was previously described in patients with MCI (Galeone, Pappalardo, Chieffi, Iavarone, & Carlomagno, 2011). However, it should be noted that when scores in individual QOL-AD items were compared between MCI patients and their informants, the item 'Memory' showed no statistical difference, which suggests that patients with MCI were quite aware of their cognitive difficulties.…”

mentioning

confidence: 82%

Quality of life in patients with mild cognitive impairment

Bárrios

Narciso

Guerreiro

et al. 2013

Aging & Mental Health

148

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Background: Quality of life (QoL) is affected in patients with dementia, but it is not clear whether it is already disturbed in more initial phases of cognitive decline, like Mild Cognitive Impairment (MCI). Aim: Compare the QoL in MCI patients with controls without cognitive impairment, and ascertain whether there are differences in the reports of QoL made by the subjects and by their informants. Methods: Two hundred participants were enrolled, divided into MCI patients (n ¼ 50), MCI informants (n ¼ 50), recruited from a memory clinic and a dementia outpatient clinic, and controls (n ¼ 50) and controls informants (n ¼ 50), recruited in a family practice clinic. QoL was assessed with the QoL in Alzheimer disease (QOL-AD) scale. Results: The total scores of the QOL-AD questionnaire were 32.1 � 6.9 for MCI patients self-report, 27.2 � 6.7 for MCI patients in the opinion of their informants, 35.3 � 4.9 for controls self-report and 35.6 � 4.9 for controls in the opinion of their informants. MCI patients had lower QOL-AD scores than controls. The QoL reported by patients with MCI was more favorable than the opinion of their informants. Conclusion: The QoL is affected at early stages of cognitive decline. The QoL reported by patients with MCI is better than the opinion of their informants, similarly to what is known in Alzheimer's disease patients. QoL appears to be an important domain to be evaluated in aging studies.

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mentioning

confidence: 82%

Quality of life in patients with mild cognitive impairment

Bárrios

Narciso

Guerreiro

et al. 2013

Aging & Mental Health

148

View full text Add to dashboard Cite

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“…Among them, 13 evaluated only this domain 20,23,27,38,39,41,44,47,[50][51][52][53]55 . Ten studies evaluated awareness of cognitive and functional deficits domains 1,18,20,[33][34][35]40,45,46,54 , nine assessed cognitive and social-emotional functioning domains 12,13,17,24,28,30,36,37,49 , and three focused on cognitive and behavioral impairment domains 14,16,42 .…”

Section: Resultsmentioning

confidence: 99%

“…Different concepts were used to define the construct of awareness [12][13][14][15][16][17][18][19][20] , anosognosia [21][22][23][24][25][26][27][28][29][30][31][32] , self-awareness 33,34 , self -appraisal 35 , insight 36,37 , cognitive insight 38 , metacognition [39][40][41] , unawareness of deficits 42 , awareness of deficit 43,44 , awareness of disease 1,45 , awareness of functioning 46 , awareness of cognitive deficits 47 , awareness of disabilities 48 , awareness of performance 49 , unawareness of memory 42,[50][51][52] , anosognosia of memory 53 , awareness of memory deficits 54,55 , awareness of memory function and functional abilities 56 , unawareness of psychosis or behavioral problems …”

Section: Resultsmentioning

confidence: 99%

Concepts and objects of awareness in Alzheimer’s disease: an updated systematic review

Lacerda¹,

Sousa²,

Santos³

et al. 2016

J. bras. psiquiatr.

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Objectives: To compare and discuss the objects of awareness in Alzheimer's disease (AD): awareness of cognitive deficits, of functional activities, of social-emotional functioning and behavioral impairment. Methods: A search in the PsycINFo, Pilots, PubMed/Medline and ISI electronic databases according to Prisma methodology was performed. We included studies about awareness in people with AD published between 2010 and 2015, with the combination of keywords: "Alzheimer AND awareness of deficits", "Alzheimer AND anosognosia", "Alzheimer AND insight", "dementia AND awareness of deficits", "dementia AND anosognosia", "dementia AND insight". The articles were categorized according to the specific object of awareness. Results: Seven hundred and ten records were identified and, after application of the exclusion criteria, 191 studies were retrieved for potential use. After excluding the duplicates, 46 studies were included. Most studies assessed the cognitive domain of awareness, followed by the functional, social-emotional, and behavioral impairment domains. Memory deficits were not sufficient to explain impaired awareness in AD. Longitudinal studies did not find discrepancies between patients and caregivers' reports, indicating that awareness is not related to cognition. Conflicting findings were observed, including the relation between awareness, mood, severity of disease, and personal characteristics. Conclusions: The studies show lack of conceptual consensus and significant methodological differences. The inclusion of samples without differentiation of dementia etiology is associated to symptomatic differences, which affect awareness domains. Awareness in AD is a complex and multidimensional construct. Different objects elicit different levels of awareness. RESUMOObjetivos: Comparar e discutir os objetos de consciência na doença de Alzheimer (DA): consciência dos déficits cognitivos, das atividades funcionais, do funcionamento socioemocional e prejuízos comportamentais. Métodos: Realizou-se uma busca nas bases de dados PsycINFo, Pilots, PubMed/Medline e ISI de acordo com a metodologia do Prisma. Os artigos incluídos, publicados entre 2010 e 2015, avaliavam a consciência na DA com as combinações de palavras-chave: "Alzheimer AND consciência do déficit", "Alzheimer AND anosognosia", "Al- zheimer AND insight", "demência AND consciência do déficit", "demência AND anosognosia", "demência AND insight". Os artigos foram categorizados conforme os objetos específicos da consciência. Resultados: Setecentos e dez estudos foram identificados e, após a aplicação dos critérios de exclusão, 191 foram selecionados. Após a exclusão dos duplicados, 46 estudos foram incluídos. A maioria dos estudos avaliou o domínio cognitivo da consciência, seguido do funcional, do funcionamento socioemocional e prejuízos comportamentais. Dé-ficits na memória não se mostraram suficientes para explicar o prejuízo da consciência na DA. Os estudos longitudinais não encontraram discrepâncias entre os relatos de pacientes e cuidadores, indicando...

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“…Conversely, no right-sided inattention or inattention of the left hemispace followed neuroleptic medication [33]. Thus, dopamine antagonists might have a normalizing or balancing effect, thereby decreasing both positive symptoms (e.g., delusions, hallucinations) as well as right neglect [76,77]. On the other hand, the association between left neglect in PS and overall negative symptomatology was suggested by Barnett [47].…”

Section: Rightward Bisection Bias Left Hemineglectmentioning

confidence: 99%

Asymmetries of Visuospatial Attention in Schizophrenia

Chieffi¹,

Villano²,

Iavarone³

et al. 2016

J Psychiatry

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Journal of Psychiatry AbstractAsymmetries of visuospatial attention has long been described in hemispatial neglect, a neurological syndrome in which brain damaged patients fail to acknowledge or explore stimuli presented to the contralesional side of space. Asymmetries for spatial attention were also investigated in schizophrenia. In this review, we report the researches that, using tasks selectively employed to study visuospatial processing in neglect patients, demonstrated hemineglect-like behaviour in schizophrenia. Intriguingly, these studies produced mixed evidence. Some researches found biases towards the left hemispace suggesting a right hemineglect, others towards the right hemispace suggesting a left hemineglect. We examine the possible factors that may have contributed in producing these conflicting findings.

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Anosognosia for memory deficit in amnestic mild cognitive impairment and Alzheimer's disease

Cited by 94 publications

References 36 publications

Quality of life in patients with mild cognitive impairment

Quality of life in patients with mild cognitive impairment

Concepts and objects of awareness in Alzheimer’s disease: an updated systematic review

Asymmetries of Visuospatial Attention in Schizophrenia

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