Another controller system for arterial pressure. AngII-vasopressin neural network of the parvocellular paraventricular nucleus may regulate arterial pressure during hypotension

Nasimi, Ali; Haddad, Fatemeh; Mirzaei-Damabi, Nafiseh; Rostami, Bahar; Hatam, Masoumeh

doi:10.1016/j.brainres.2021.147618

Cited by 4 publications

(10 citation statements)

References 62 publications

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“…However in neither groups did AngII produce tachycardia, which is different from other experimental groups. A possible explanation is that in this study and in all our previous studies (e.g., Khanmoradi & Nasimi, 2016, 2017a,b; Nasimi et al., 2021), AngII did not cause tachycardia in all individual cases; we had bradycardia and no response too. So it is possible to see an average of no response in a group.…”

Section: Discussionsupporting

confidence: 50%

“…The control groups (1–2): Initially, AngII (100 µM, 100 nl/side, Sigma, Saint Louis, MO USA) (Nasimi et al., 2021) was microinjected into the PVNp. Then after the arterial pressure returned to baseline value (∼25–30 min later), saline (100 nl/side, n = 8 rats) or DMSO (100 nl/side, Sigma, Saint Louis, MO USA, n = 7 rats) was microinjected into the PVNp.…”

Section: Methodsmentioning

confidence: 99%

“…The control groups (1-2): Initially, AngII (100 µM, 100 nl/side, Sigma, Saint Louis, MO USA) (Nasimi et al, 2021) was microinjected into the PVNp.…”

Section: Experimental Groupsmentioning

confidence: 99%

“…All the components of the renin‐angiotensin system, such as angiotensinogen, converting enzyme, angiotensin II (AngII) receptors, and Ang II immunoreactive cells, exist in the PVN (Chappell et al., 1989; Ferguson & Washburn, 1998; Fuxe et al., 1976; Khanmoradi & Nasimi, 2017a; Lind et al., 1985; Stern, 2004). Ang II in PVNp acts through two receptor subtypes: AT1 and AT2, both of which are members of the G‐protein‐coupled receptor family (Miura et al., 2013; Nasimi et al., 2021; Wright & Harding, 2011). It has been shown that microinjection of AngII into the PVN increases neurons' firing rate and consequently produces a short or long pressor response.…”

Section: Introductionmentioning

confidence: 99%

“…So it was verified that the PVN renin–angiotensin system is a major regulatory system of the cardiovascular system (Khanmoradi & Nasimi, 2017b). in addition, in a study investigating the interaction between angiotensinergic and vasopressinergic systems of the PVN, it was found that AngII and vasopressin neurons reciprocally activate each other, working together as one system may control arterial pressure during hypotension (Nasimi et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

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In the parvocellular part of paraventricular nucleus, glutamatergic and GABAergic neurons mediate cardiovascular responses to AngII

Rastegarmanesh

Rostami

Nasimi

et al. 2022

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Angiotensinergic, GABAergic, and glutamatergic neurons are present in the parvocellular region of the paraventricular nucleus (PVNp). It has been shown that microinjection of AngII into the PVNp increases arterial pressure (AP) and heart rate (HR). The presence of synapses between the angiotensinergic, GABAergic, and glutamatergic neurons has been shown in the PVNp. In this study, we investigated the possible interaction between these three systems of the PVNp for control of AP and HR. All drugs were bilaterally (100 nl/side) microinjected into the PVNp of urethaneanesthetized rats, and AP and HR were recorded continuously. Microinjection of AngII into the PVNp produced pressor and tachycardia responses. Pretreatment of PVNp with AP5 or CNQX, glutamatergic NMDA and AMPA receptors antagonists, attenuated the responses to AngII. Pretreatment of PVNp with bicuculline greatly attenuated the pressor and tachycardia responses to AngII.In conclusion, this study provides the first evidence that pressor and tachycardia responses to microinjection of AngII into the PVNp are partly mediated by both NMDA and non-NMDA receptors of glutamate. Activation of glutamatergic neurons by AngII stimulates the sympathoexcitatory neurons. We also showed that the responses to AngII were strongly mediated by GABA A receptors, probably through activation of GABAergic neurons, which in turn inhibit sympathoinhibitory neurons.

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Section: Discussionsupporting

confidence: 50%

Section: Methodsmentioning

confidence: 99%

“…The control groups (1-2): Initially, AngII (100 µM, 100 nl/side, Sigma, Saint Louis, MO USA) (Nasimi et al, 2021) was microinjected into the PVNp.…”

Section: Experimental Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In the parvocellular part of paraventricular nucleus, glutamatergic and GABAergic neurons mediate cardiovascular responses to AngII

Rastegarmanesh

Rostami

Nasimi

et al. 2022

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Hypothalamic paraventricular nucleus augments baroreflex sensitivity, role of angiotensin II

2023

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Epigenetic control of metabolic identity across cell types

Pacheco,

Gerard,

Mangan

et al. 2024

Preprint

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Constraint-based network modelling is a powerful tool for analysing cellular metabolism at genomic scale. Here, we conducted an integrative analysis of metabolic networks reconstructed from RNA-seq data with paired epigenomic data from the EpiATLAS resource of the International Human Epigenome Consortium (IHEC). Applying a state-of-the-art contextualisation algorithm, we reconstructed metabolic networks across 1,555 samples corresponding to 58 tissues and cell types. Analysis of these networks revealed the distribution of metabolic functionalities across human cell types and provides a compendium of human metabolic activity. This integrative approach allowed us to define, across tissues and cell types, i) reactions that fulfil the basic metabolic processes (core metabolism), and ii) cell type-specific functions (unique metabolism), that shape the metabolic identity of a cell or a tissue. Integration with EpiATLAS-derived cell type-specific gene-level chromatin states and enhancer-gene interactions identified enhancers, transcription factors, and key nodes controlling core and unique metabolism. Transport and first reactions of pathways were enriched for high expression, active chromatin state, and Polycomb-mediated repression in cell types where pathways are inactive, suggesting that key nodes are targets of repression. This integrative analysis forms the basis for identifying regulation points that control metabolic identity in human cells.

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Another controller system for arterial pressure. AngII-vasopressin neural network of the parvocellular paraventricular nucleus may regulate arterial pressure during hypotension

Cited by 4 publications

References 62 publications

In the parvocellular part of paraventricular nucleus, glutamatergic and GABAergic neurons mediate cardiovascular responses to AngII

In the parvocellular part of paraventricular nucleus, glutamatergic and GABAergic neurons mediate cardiovascular responses to AngII

Hypothalamic paraventricular nucleus augments baroreflex sensitivity, role of angiotensin II

Epigenetic control of metabolic identity across cell types

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