Another human chimaera

Section: Twin Chimerasmentioning

confidence: 99%

“…ever, his status is not so proved because mix tures have only been observed in his blood. Battey et al [2] considered Mrs. P. M. to be a twin chimera because she was fertile.…”

Section: Chimeras Of Unestablished Typementioning

confidence: 99%

Section: Fertilitymentioning

confidence: 99%

See 1 more Smart Citation

Blood Group Chimeras

Tippett¹

1983

“…It is understood that an individual may carry an XY or XX line in contradiction to their phenotypic sex and there is no relevance in this to the 'true' sex unless the tissues of the reproductive organs are involved [15]; however, it is most unusual to find a fertile XX/XY dispermie chimaera who is physically and psychologically a normal female, and we believe that Mrs. K. is the first one to be reported.…”

Section: Discussionmentioning

confidence: 96%

The Liverpool Chimaera

Bromilow¹,

Duguid²

1989

A dispermie human chimaera is described who is a fertile female XX/XY chimaera. The chimaera was discovered due to anomalies found during routine antenatal testing. The patient had two red cell populations differing in three blood group sysems; ABO, Rh and MN. Analysis of cultured lymphocytes showed 70% of cells to have the 46, XY male karyotype and analysis of cultured skin cells showed 30% of cells to have the 46, XY karyotype.

“…Battey et al [2], however, studied a secre tar of A, H, and Lea antigens whose saliva lacked Leb during pregnancy but con tained Leb antigen after delivery. In our study, 39% of pregnant women who secreted Leb antigen in saliva had the Le(a-b-) red cell phenotype at the time of delivery.…”

Section: Lewis Phenotype Of Erythrocytesmentioning

confidence: 99%

Lewis Phenotype of Erythrocytes and Leb-Active Glycolipid in Serum of Pregnant Women

Lundblad¹,

Zopf²,

Hammar³

et al. 1981

In an attempt to provide an explanation for the previously reported effect of pregnancy on the Lewis phenotype of erythrocytes, the level of Le^b-active glycolipid in serum was compared with the reactions of erythrocytes, using samples obtained from 73 nonpregnant women, 74 women at the time of delivery, and 2 women at weekly intervals during their pregnancy. In this Swedish population, the frequency of the Le(a-b-) blood group increased from 11% in nonpregnant women to 36% in women at the time of delivery. Among Le(a-b+) women of all ABO groups, those who were Ax most often became Le(b-) during pregnancy. The change in phenotype occurred as early as the 24th week of gestation; the Le^b antigen was again detectable within 6 weeks after delivery. The concentration of Le^b glycolipid in serum, as measured by radioimmunoassay, decreased only slightly during pregnancy. The repartition of glycolipids, secondary to the increased ratio of lipoprotein to red cell mass that occurs during pregnancy, may account for the relative lack of Lewis glycolipid on erythrocytes.