Another perspective on genetic risk assessment for cancer

Knell, Ellen R.; Kelly, Patricia T.

doi:10.1007/bf00962544

Cited by 2 publications

(1 citation statement)

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“…These data provide relative risk estimates for individuals with first-, second-, or third-degree relatives affected, and fiirther characterize risk based on age of onset and whedier disease was bilateral (Macklin, 1959;Anderson, 1971;1976;Brinton et al, 1979;1982;Sattin et al, 1985;Ottman et al, 1986;Tulinius et al, 1992;Slatteiy et al, 1993;Carter et al, 1989;Colditz et al, 1993). While population-derived data are fiilly appropriate for risk counseling for polygenic disorders, it has been recognized that such counseling will underestimate the risk in hereditary syndromes, and overestimate the risk in "sporadic" cases (Knell, 1993). This has led to the development of multidisciplinary genetic counseling approaches for common adult malignancies which integrate empiric, Mendelian, and Bayesian methods of risk estimation (Offit and Brown, 1994).…”

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confidence: 99%

Psychobehavioral Impact of Genetic Counseling and Breast Cancer Gene Testing in Healthy Women of African Descent

Valdimarsdottir¹

1997

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mentioning

confidence: 99%

Psychobehavioral Impact of Genetic Counseling and Breast Cancer Gene Testing in Healthy Women of African Descent

Valdimarsdottir¹

1997

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Complexities in Cancer Risk Counseling: Presentation of Three Cases

Schneider

Peters

Knell

et al. 1997

Journal of Genetic Counseling

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Complexities abound in the identification and management of families at increased risk for inherited forms of cancer. One of the ways to learn as a profession how best to provide cancer risk counseling (CRC) is to share counseling experiences. Such cases can provide insight into the issues raised by families and ways in which genetic counselors have handled complex situations. Here we describe three CRC cases initially presented at the 1995 American College of Medical Genetics meeting. The first case involves balancing the importance of informing a family of the presence of an inherited cancer syndrome with the family's right "not to know." The second case illustrates the difficulties in assisting an individual to make medical management decisions in the face of uncertain risk information. The third case describes the complex interactions with a woman before and after her decision to have prophylactic surgery.

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Another perspective on genetic risk assessment for cancer

Cited by 2 publications

References 3 publications

Psychobehavioral Impact of Genetic Counseling and Breast Cancer Gene Testing in Healthy Women of African Descent

Psychobehavioral Impact of Genetic Counseling and Breast Cancer Gene Testing in Healthy Women of African Descent

Complexities in Cancer Risk Counseling: Presentation of Three Cases

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