Anoxia and Human Pulmonary Vascular Resistance 12

Westcott, Richard N.; Fowler, Noble O.; Scott, Ralph C.; Hauenstein, Virgil; McGuire, Johnson

doi:10.1172/jci102517

Cited by 148 publications

(51 citation statements)

References 14 publications

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“…A significant negative correlation was found (r 0-.54; p = < 0.001). Correlation between pulmonary artery diastolic pressure and pulmonary "capillary" pressure was determined and is shown on semilogarithmic paper ( The finding of a significant negative correlation between arterial oxygen saturation and pulmonary arteriolar resistance is of interest, in view of the evidence that hypoxia produces pulmonary artery vaso-constriction (6,8). We believe, however, that these data alone would not necessarily permit one to draw that conclusion.…”

Section: Methodsmentioning

confidence: 99%

Pulmonary Artery Diastolic Pressure: Its Relationship to Pulmonary Arteriolar Resistance and Pulmonary “Capillary” Pressure 1

Fowler¹,

Westcott²,

Scott³

1952

J. Clin. Invest.

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In the systemic circulation, one ordinarily may assume increased peripheral resistance when the diastolic pressure is elevated (1). It is the purpose of this paper to ascertain whether a similar relationship exists within the lesser circulation of man. MATERIALSubjects were selected at random from the medical wards of the Cincinnati General Hospital. Some were normal convalescents; others were suffering from various types of heart and lung disease (Table I). Satisfactory data were obtained in 54 patients. METHODSubjects were studied in the fasting condition, sedated by 0.1 or 0.2 gm. of seconal. Catheterization of the right side of the heart was done as described previously (2). Pulmonary "capillary" pressure was obtained by the method of Hellems and co-workers (3). The criteria of satisfactory pulmonary "capillary" pressures were 1) the nature of the pressure curve, showing "a" and "c" waves; 2) the peripheral location of the catheter; and 3) the securing of blood saturated with oxygen from the wedged catheter tip. In some instances no blood could be obtained from the wedged catheter. In the majority of instances a double lumen catheter was used, so that pulmonary artery and pulmonary "capillary" pressures could be recorded simultaneously. In some instances, a single lumen catheter was employed; in these cases pulmonary "capillary" pressure was recorded first; then the catheter tip was quickly withdrawn into the proximal portion of the pulmonary artery so that almost simultaneous recording of the pulmonary artery pressure could be made.

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Section: Methodsmentioning

confidence: 99%

Pulmonary Artery Diastolic Pressure: Its Relationship to Pulmonary Arteriolar Resistance and Pulmonary “Capillary” Pressure 1

Fowler¹,

Westcott²,

Scott³

1952

J. Clin. Invest.

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“…In le 5 subjectos de controlo in qui il habeva un augmento medie de 6 (ab 37 ad 43) mm de Hg in le tension de C02 arterial e un triplice augmento del ventilation per minuta-tanto le tension como etiam le fluxo del sanguine pulmono-arterial remaneva inalterate. In le 10 patientes con chronaic emphysema pulmonar in qui il habeva un simile augmento in le tension de CO2 arterial (ab 45 ad 52) e un duplice augmento del ventilation per minuta-le rendimento cardiac montava per 14 pro cento, e le tension pulmono-arterial medie esseva augmentate per 4 mm de Hg.…”

Section: Arterial Blood Oxyhemoglobin Saturationunclassified

Effects of Breathing Carbon Dioxide upon the Pulmonary Circulation

1960

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The effects of inhaling 5 per cent carbon dioxide in air on the pulmonary arterial blood pressure and flow were studied in 5 subjects with normal pulmonary circulations and in 10 patients with chronic pulmonary emphysema. In the 5 control subjects, with an average increase in arterial P CO CO2 of 6 mm. Hg (37 to 43) and a 3-fold increase in minute ventilation, both pulmonary arterial blood pressure and flow remained unchanged. In the 10 patients with chronic pulmonary emphysema with a similar increase in arterial P CO CO2 (45 to 52) and a 2-fold increase in minute ventilation, there was a 14 per cent increase in cardiac output and a rise in pulmonary arterial mean pressure of 4 mm. Hg. In these patients an increment in pulmonary arterial pressure was invariably associated with an appreciable increment in blood flow. The present study affords no support for the view that the breathing of air enriched with carbon dioxide elicits pulmonary vasoconstriction in either normal subjects or in patients with chronic pulmonary disease.

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“…In humans, large inter-individual differences exist in the magnitude of the pulmonary pressure response to hypoxia [19][20][21][22], with some subjects demonstrating exaggerated increases in pulmonary arterial pressure [23,24]. There are very few studies available in North-India where the high altitude hypertension has been focused.…”

Section: Introductionmentioning

confidence: 99%

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Ch¹,

Doza²,

Kumar³

2017

UNOAJ

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The study included ACE gene I/D polymorphism and its association between high altitude hypertension. Genetic, biochemical, anthropometric and Physiometeric results were analyzed using statistical software. The results were non-significant for I/D polymorphism.Objective: ACE is the major enzyme of hypertension and with most commonly reviewed I/D polymorphism. High-altitude exposes various physiological and biochemical changes, which contributes a rise in systemic blood pressure of the body. There are very few studies available in North-India, with a core focus on the high altitude hypertension. Therefore, a current study supported an interest to find out the association of high altitude hypertension with ACE gene I/D polymorphism.Methods: to study the significant association with respect to altitude, genetic, biochemical, anthropometric and physio-metric comparison were conducted among 98 individuals where 489nbeing hypertensive patients and other half being normotensive, inclusive of both males and females. The entire results were finally examined and analyzed using statistical software SPSS 16.0 version. Results:According to study results, mean arterial blood pressure and triglycerides were significantly (p<0.05) associated with SBP among both hypertensive and normotensives. Whereas HDL, LDL-HDL ratio, CHO-HDL were significantly associated only among hypertensive, and age, PP, and SpO2 have been significantly (p<0.05) associated with SBP among normotensive, a strong predictor for SBP. Conclusion:The genotypic observations were visibly linked with the disease, however, the results were statistically non-significant (ID/DD vs. II; OR: 0.54, 95% CI: 0.20-1.44, p= 0.217). A further study with considerate knowledge of noteworthy dynamics, mainly, altitude, population size, and ethnicity are recommended.

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Anoxia and Human Pulmonary Vascular Resistance 12

Cited by 148 publications

References 14 publications

Pulmonary Artery Diastolic Pressure: Its Relationship to Pulmonary Arteriolar Resistance and Pulmonary “Capillary” Pressure 1

Pulmonary Artery Diastolic Pressure: Its Relationship to Pulmonary Arteriolar Resistance and Pulmonary “Capillary” Pressure 1

Effects of Breathing Carbon Dioxide upon the Pulmonary Circulation

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

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