ANRIL and atherosclerosis

Chen, Li; Qu, Hua; Guo, Ming; Zhang, Ying; Cui, Yuanyuan; Yang, Qiaoning; Bai, Ru; Shi, Donglei

doi:10.1111/jcpt.13060

Cited by 42 publications

(37 citation statements)

References 95 publications

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“…Generally, ANRIL is a prognostic biomarker and an oncomiR in human cancers, such as lung cancer, gastric cancer, esophageal squamous cell carcinoma [17]. In addition, dysregulation of ANRIL promote the development of atherosclerosis and leads to coronary heart disease through mediating single nucleotide polymorphisms and injuring endothelial cell [18,19]. Furthermore, ANRIL mediates VEGF to effects on diabetic retinopathy [20].…”

Section: Discussionmentioning

confidence: 99%

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR-7 through NF-κB Pathway

Yi-jie

2021

Preprint

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Background Long non-coding RNAs (lncRNAs) are dysregulation in periodontitis development and involved in osteogenesis. The current study aimed was to investigate the function of lncRNA ANRIL in periodontal ligament cells (PDLCs) and potential molecular mechanisms.Methods Firstly, the level of ANRIL was tested by qPCR. Then PDLCs were treated with a mineralizing solution to induce the osteogenic differentiation. ALP activity was measured and protein levels of BMP2, Osterix, and OCN were measured by western blot. A target of ANRIL was verified using dual-luciferase reporter assay. MiR-7 level was measured by qPCR and the signalings of NF-κB pathway were tested by western blot.Results ANRIL expression was downregulated in PDL tissues. Next, ALP activity and protein levels of BMP2, Osterix, and OCN were reduced to show PDLCs were differentiated. ANRIL level was increased in differential PDLCs, and which knockdown inhibited osteogenic differentiation. Then, miR-7 was found as a target of ANRIL. The miR-7 level was upregulated in PDL tissues and reduced in differential PDLCs. Inhibition of miR-7 suppressed ALP activity and BMP2, Osterix, and OCN expression. Moreover, inhibition of miR-7 reversed the effects on the osteogenic differentiation induced by knockdown of ANRIL. Besides, the levels of p-P65 and p-IκBα were elevated by ANRIL downregulation and were rescued by suppressing miR-7.Conclusions Knockdown of ANRIL inhibited osteogenic differentiation via sponging miR-7 through the NF-κB pathway, suggesting that ANRIL might be a therapeutic target for periodontitis.

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Section: Discussionmentioning

confidence: 99%

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR-7 through NF-κB Pathway

Yi-jie

2021

Preprint

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“…ANRIL is a long noncoding RNA of 126 kbp containing 19 exons located at the INK4 locus of the chromosome 9p21 region [66]. Note that the INK4 locus is one of the strongest genetic susceptibility loci for cardiovascular diseases [67]. The lncRNA ANRIL was first discovered in patients with familial melanoma with neural system tumors.…”

Section: Lncrna Cancer Susceptibility Candidate 2 (Casc2)mentioning

confidence: 99%

Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension

Ali

Dua

Spiekerkoetter

et al. 2021

Cells

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Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an urgent need to develop novel therapies to treat this disease. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play critical roles in pulmonary vascular remodeling and PAH. LncRNAs are implicated in pulmonary arterial endothelial dysfunction by modulating endothelial cell proliferation, angiogenesis, endothelial mesenchymal transition, and metabolism. LncRNAs are also involved in inducing different pulmonary arterial vascular smooth muscle cell phenotypes, such as cell proliferation, apoptosis, migration, regulation of the phenotypic switching, and cell cycle. LncRNAs are essential regulators of gene expression that affect various diseases at the chromatin, transcriptional, post-translational, and even post-translational levels. Here, we focus on the role of LncRNAs and their molecular mechanisms in the pathogenesis of PAH. We also discuss the current research challenge and potential biomarker and therapeutic potentials of lncRNAs in PAH.

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“…Single nucleotide polymorphisms (SNPs) and splice variants of ANRIL were reported to regulate endothelial cell activities involved in coronary artery heart disease (CAD) and MI (98)(99)(100)(101)(102)(103). Abnormal expression of ANRIL is associated with vascular endothelium injury and proliferation, migration, and apoptosis of VSMCs; which also contribute to mononuclear cell adhesion and proliferation (104,105). ANRIL knockdown induced cardiomyocyte apoptosis in acute MI by regulating IL-33/ST2 or Akt (106,107).…”

Section: Anrilmentioning

confidence: 99%

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Sepsis is a syndrome with life-threatening organ dysfunction induced by a dysregulated host response to infection. The heart is one of the most commonly involved organs during sepsis, and cardiac dysfunction, which is usually indicative of an extremely poor clinical outcome, is a leading cause of death in septic cases. Despite substantial improvements in the understanding of the mechanisms that contribute to the origin and responses to sepsis, the prognosis of sepsis-induced cardiac dysfunction (SICD) remains poor and its molecular pathophysiological changes are not well-characterized. The recently discovered group of mediators known as long non-coding RNAs (lncRNAs) have presented novel insights and opportunities to explore the mechanisms and development of SICD and may provide new targets for diagnosis and therapeutic strategies. LncRNAs are RNA transcripts of more than 200 nucleotides with limited or no protein-coding potential. Evidence has rapidly accumulated from numerous studies on how lncRNAs function in associated regulatory circuits during SICD. This review outlines the direct evidence of the effect of lncRNAs on SICD based on clinical trials and animal studies. Furthermore, potential functional lncRNAs in SICD that have been identified in sepsis studies are summarized with a proven biological function in research on other cardiovascular diseases.

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ANRIL and atherosclerosis

Cited by 42 publications

References 95 publications

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR-7 through NF-κB Pathway

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR-7 through NF-κB Pathway

Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

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