ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma

Chen, Deyu; Zhang, Zhaoyue; Mao, Chaoming; Zhou, Yuepeng; Yu, Lian; Yin, Yue; Wu, Shengjun; Mou, Xiao; Zhu, Yan

doi:10.1016/j.cellimm.2014.03.015

Cited by 103 publications

(98 citation statements)

References 20 publications

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“…Recent research focusing on lncRNAs has improved our understanding of the complex regulatory mechanisms underlying tumorigenesis and metastasis in human cancers [10]. In ESCC, the dysregulation of some lncRNAs, such as MALAT1 [23,24], 91H [25], HOTAIR [26], ANRIL [27,28], and MEG3 [29,30], promotes or inhibits the progression and metastasis of tumors and is closely associated with poor survival [31]. These results confirm that lncRNAs are potential diagnostic and therapeutic biomarkers in ESCC.…”

Section: Discussionmentioning

confidence: 75%

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

Yang

Tien

et al. 2018

Cell Physiol Biochem

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Background/Aims: Considerable evidence indicates that long noncoding RNAs (lncRNAs) exert importantly regulatory functions during human cancer initiation and progression and are promising biotargets in the flight against cancer. Methods: In this study, we evaluated the role of the lncRNA LINC01133 in esophageal squamous cell carcinoma (ESCC). LINC01133 expression in ESCC was examined by quantitative real-time PCR. The correlations between LINC01133 expression and clinicopathological variables and survival were examined by the χ² test, Kaplan–Meier method, log-rank test, and univariate Cox regression analysis. Results: LINC01133 expression levels were frequently lower in ESCC tissues and cell lines than in paired normal tissues and an immortalized esophageal epithelial cell line, respectively. The expression of LINC01133 decreased in a TNM stage- and lifestyle-independent manner. LINC01133 was an independent protective factor and had an anti-tumor effect in the early stage of ESCC development. More importantly, we discovered that drinking status in our cohort impaired the predictive accuracy of LINC01133 for patients with ESCC. Furthermore, a new risk model combining LINC01133 expression, drinking status, and TNM stage provided better survival discrimination compared with three other predictors. Conclusions: Our data indicate that a loss of LINC01133 expression is a potential poor prognostic biomarker and therapeutic target for ESCC and provide additional prognostic information to improve the outcomes of ESCC patients.

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Section: Discussionmentioning

confidence: 75%

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

Yang

Tien

et al. 2018

Cell Physiol Biochem

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“…Previously studies have indicated that ANRIL could silence p15 INK4 transcription and contribute to cancer cells proliferation (18). The results of qPCR showed that p15 and p16 expression was increased in SPCA1 and H1299 cells with transfection of si-ANRIL; however, there was no significant difference of p15 expression in PC9 cells when knockdown of ANRIL expression (Fig.…”

Section: Anril Silences Klf2 and P21 Transcription By Binding With Ezh2mentioning

confidence: 80%

“…Our previous study showed that lncRNA ANRIL was significantly upregulated in gastric cancer, and increased ANRIL promoted gastric cancer cells proliferation and inhibited apoptosis by epigenetic silencing of miR99a and miR449a transcription (16). Moreover, ANRIL can bind to and recruits PRC2 to repress the expression of p15INK4B locus, which resulted in increased cell proliferation (17,18). However, the ANRIL clinical significance and potential role in NSCLC development and progression is still not documented.…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA ANRIL Promotes Non–Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

Nie

Sun

Yang

et al. 2015

Molecular Cancer Therapeutics

338

291

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Recent evidence highlights long noncoding RNAs (lncRNA) as crucial regulators of cancer biology that contribute to essential cancer cell functions such as cell proliferation, apoptosis, and metastasis. In non-small cell lung cancer (NSCLC), several lncRNAs' expressions are misregulated and have been nominated as critical actors in NSCLC tumorigenesis. LncRNA ANRIL was first found to be required for the PRC2 recruitment to and silencing of p15 INK4B , the expression of which is induced by the ATM-E2F1 signaling pathway. Our previous study showed that ANRIL was significantly upregulated in gastric cancer, and it could promote cell proliferation and inhibit cell apoptosis by silencing of miR99a and miR449a transcription. However, its clinical significance and potential role in NSCLC is still not documented. In this study, we reported that ANRIL expression was increased in NSCLC tissues, and its expression level was significantly correlated with tumor-node-metastasis stages and tumor size. Moreover, patients with high levels of ANRIL expression had a relatively poor prognosis. In addition, taking advantage of loss-of-function experiments in NSCLC cells, we found that knockdown of ANRIL expression could impair cell proliferation and induce cell apoptosis both in vitro and vivo. Furthermore, we uncover that ANRIL could not repress p15 expression in PC9 cells, but through silencing of KLF2 and P21 transcription. Thus, we conclusively demonstrate that lncRNA ANRIL plays a key role in NSCLC development by associating its expression with survival in patients with NSCLC, providing novel insights on the function of lncRNA-driven tumorigenesis.

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“…Chen et al, in a recent study, showed that ANRIL inhibits the functions of transforming growth factor β1 and p15 INK4b [96]. They suggested this role for ANRIL in the occurrence and development of ESCC.…”

Section: Anril As a Suppressor Of Cyclin-dependent Kinase Inhibitorsmentioning

confidence: 96%

Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

2014

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Different long non-coding RNAs (lncRNAs) are transcribed within the genome. Although initially argued to be spurious transcriptional noise, these RNAs play important roles in biological pathways, as shown by different studies. Also, there are some reports about the role of lncRNAs in different cancers. They can contribute to the development and progression of cancer by the functioning as oncogene or/and tumor suppressor molecules. In this review, we point to some important lncRNAs as examples which seem to be involved in cancer initiation/progression.

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ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma

Cited by 103 publications

References 20 publications

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

Long Noncoding RNA ANRIL Promotes Non–Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

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