ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma

Xu, Shi-Qiong; Wang, Huixue; Pan, Hui; Shi, Yingyun; Li, Tianyuan; Ge, Shengfang; Jia, Renbing; Zhang, He

doi:10.1016/j.canlet.2016.07.024

Cited by 58 publications

(43 citation statements)

References 34 publications

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“…The most common primary ocular cancer in adults is uveal melanoma, which can arise in the choroid, ciliary body and iris. The most common ocular cancer in children is retinoblastoma, which affects 325 children in the USA per year 69-71. The relationship between autophagy and cancer is complicated.…”

Section: Autophagy and Ocular Cancermentioning

confidence: 99%

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

Chai

Zhang

et al. 2016

Int. J. Biol. Sci.

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Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis.Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit. In addition, the activation of autophagy is directly linked to the development of eye diseases such as age-related macular degeneration (ARMD), cataracts, diabetic retinopathy (DR), glaucoma, photoreceptor degeneration, ocular tumours, ocular infections and thyroid-associated ophthalmopathy (TAO). A high level of autophagy defends against external stress; however, excessive autophagy can result in deterioration, as observed in ocular diseases such as ARMD and DR.This review summarizes recent developments elucidating the relationship between autophagy and ocular diseases and the potential roles of autophagy in the pathogenesis and treatment of these diseases.

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Section: Autophagy and Ocular Cancermentioning

confidence: 99%

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

Chai

Zhang

et al. 2016

Int. J. Biol. Sci.

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“…The expression levels of ANRIL [52, 88, 89] and SNHG5 [90] in primary melanoma samples have so far been compared with normal tissue only and have not yet been studied in relation to melanoma stage. ANRIL was overexpressed in 18 cutaneous and 10 uveal primary melanoma samples compared with 9 healthy tissue samples including benign nevi, choroid and retina tissue.…”

Section: Lncrnas As Biomarkers For Cutaneous Melanomamentioning

confidence: 99%

“…ANRIL was overexpressed in 18 cutaneous and 10 uveal primary melanoma samples compared with 9 healthy tissue samples including benign nevi, choroid and retina tissue. [88]…”

Section: Lncrnas As Biomarkers For Cutaneous Melanomamentioning

confidence: 99%

Long non-coding RNAs in cutaneous melanoma: clinical perspectives

et al. 2017

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Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the pathogenesis of cutaneous melanoma through a variety of pathways and molecular interactions. Some of these lncRNAs are possible biomarkers or therapeutic targets for malignant melanoma.

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“…This implies that ANRIL is significantly involved in cell proliferation and furthermore in cell proliferation after DNA damage repair (see Table 1) [94,95]. Xu et al indicated that ANRIL was overexpressed in cutaneous melanoma and uveal melanoma compared to normal tissue [96]. Knockdown of ANRIL by siRNA restored the ability of two tumor cell lines (A375 and OM431) to transcribe INK4A and INK4B .…”

Section: Long Non-coding Rnas In Melanomamentioning

confidence: 99%

“…Knockdown of ANRIL by siRNA restored the ability of two tumor cell lines (A375 and OM431) to transcribe INK4A and INK4B . This reduced the cell’s ability to migrate and form colonies and ANRIL might therefore be a valid therapeutic target [96]. …”

Section: Long Non-coding Rnas In Melanomamentioning

confidence: 99%

Function and Clinical Implications of Long Non-Coding RNAs in Melanoma

Richtig

Ehall

Richtig

et al. 2017

IJMS

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Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic) regulation of cell growth, invasion, and other important cellular functions. Consequently, recent research activities focused on the discovery of these lncRNAs in a broad spectrum of human diseases, especially cancer. Additional efforts have been undertaken to dissect the underlying molecular mechanisms employed by lncRNAs. In this review, we will summarize the growing evidence of deregulated lncRNA expression in melanoma, which is linked to tumor growth and progression. Moreover, we will highlight specific molecular pathways and modes of action for some well-studied lncRNAs and discuss their potential clinical implications.

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ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma

Cited by 58 publications

References 34 publications

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

Long non-coding RNAs in cutaneous melanoma: clinical perspectives

Function and Clinical Implications of Long Non-Coding RNAs in Melanoma

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