Ansellone A, a Sesterterpenoid Isolated from the Nudibranch Cadlina luteromarginata and the Sponge Phorbas sp., Activates the cAMP Signaling Pathway

Abstract

Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new "ansellane" sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.

Total Synthesis of the Potent cAMP Signaling Agonist (−)-Alotaketal A

“…collected in Papua New Guinea (Figure 1). 6 These compounds were found to potently activate cAMP cell signaling in the absence of hormone binding in a cell-based pHTS-CRE luciferase reporter gene assay with EC 50 values of 18 and 240 nM, respectively. In contrast, forskolin activates the cAMP signaling with an EC 50 of 3 μM.…”

A new family of sesterterpenoids isolated around the Pacific Rim

“…The rst of the ansellanes was reported in 2010 by Andersen et al 15 Ansellone A (30) was isolated from the marine sponge Phorbas sp. and from the nudibranch Cadlina luteomarginata observed feeding on the sponge at the time of collection in British Columbia, Canada (Fig.…”

“…15 Modulation of the cAMP signalling pathway is used in stem cell techniques and is important for the development of treatments for several diseases including heart failure, cancer, and neurodegenerative diseases. As such, the development of new modulators of this pathway is potentially of high medicinal value (Scheme 2).…”

A new derivative of phorbaketals isolated from a Marine Sponge Phorbas species

“…[7][8][9] Recently, we have reported novel skeletal sesterterpenoids phorbaketal and phorbasone from this organism collected in the Korean seawater. [10][11] These compounds exhibited mild activities against three human cancer cells and the effect on calcium deposition in the mesenthymal C3H10T1/2 cells, respectively.…”