Antacid activity of Laportea aestuans (L.) Chew

Christensen, Charlotte Bremer; Soelberg, Jens; Jäger, Anna K.

doi:10.1016/j.jep.2015.05.026

Cited by 16 publications

(17 citation statements)

References 9 publications

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“…16 The solution was titrated with hydrochloric acid having a pH of 1.2 (ref. 17) to an end point of pH 3, according to Fordtran’s model. 16 The pH was constantly measured using a pH meter, and values were recorded every minute.…”

Section: Methodsmentioning

confidence: 99%

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

et al. 2016

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Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.

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Section: Methodsmentioning

confidence: 99%

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

et al. 2016

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“…In herbal drug development, the dose calculation is the major problem, whereas in the current study, the dose (666 mg or 400 mg, etc.) was decided as per the report of Christensen et al., 2015 [29] . Antacids are used in gastroesophageal reflux‐related symptoms and the FDA recommends them for the first‐line treatment for heartburn in pregnancy [30] .…”

Section: Resultsmentioning

confidence: 99%

“…The resulting test solutions were titrated by using the prepared artificial gastric acid (800 U/l pepsin in 34 mM NaCl having a pH of 1.2 adjusted by using HCl) to the end point pH 3 as per Fordtran's model. [29,46] The rate of secretion of artificial gastric acid was kept at 3 mL/min and the pH was recorded at a regular time interval of 1 min.…”

Section: Antacid Activitymentioning

confidence: 99%

Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under‐Utilized Part

Gandhi,

Prasad,

Kumar

et al. 2023

Chemistry & Biodiversity

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Mimosa pudica L. (MP) is well‐known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES‐based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μg/g, respectively. Using GC/MS/MS analysis, fatty acid like oleic acid were identified. In ICP‐OES analysis, a significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The observed TPC and TFC for MP leaf extracts was 44.327 (±1.041) mg GAE/ g of wt. and 214.217 (±4.372) mg QCE/ g of wt., respectively. The DPPH assay depicted a strong antioxidant activity of MP leaf extracts with IC50 values of 0.796 (±0.081) mg/mL and a TEAC value of 0.0356 (±0.0003). A significant antacid activity (666 mg MP+400 mg CaCO3 >400 mg CaCO3 ≫666 mg Gelusil) of MP leaves was noticed. The methanolic extract of MP leaves demonstrated anti‐microbial activity against Staphylococcus aureus (15±2mm), Pseudomonas aeruginosa (12±2mm) and Escherichia coli (10±2mm). In silico studies confirmed the in vitro results obtained for antioxidant, antiacid, and anti‐microbial activities. In addition, in silico studies revealed the anti‐cancerous and anti‐inflammatory potential of the MP leaves. In summary, this study demonstrated the medicinal significance of MP leaves and the conversion of agro‐waste or the under‐utilized part of MP into pharmaceutical potent materials. Consequently, the present study highlighted that MP leaves alone have medicinal importance with good nutritional utility and possess large promise in the pharma industry along with improving bio‐valorization and the environment.

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“…The mixture was warmed till 37 °C and was constantly stirred at 30 rpm on a temperature‐controlled magnetic stirrer. The resultant solutions were titrated with artificial gastric acid (prepared with 800 U/l pepsin in 34 mM NaCl, pH 1.2 adjusted with HCl) till pH 3 was achieved, following the Fordtran's model [15,16] . The artificial gastric acid was delivered at a rate of 3 mL/min and pH was recorded at the regular time intervals of 1 minute.…”

Section: Methodsmentioning

confidence: 99%

A Comparative Analysis of Phytochemicals, Metal Ions, Volatile Metabolites in Heart Wood, Stem Bark and Leaves of Salix alba L. along with in Vitro Antioxidant, Antacid, Antimicrobial Activities for Sake of Environment Conservation by Substitution of Stem Bark With Leaf

Gandhi,

Rawat,

Singh Dhanjal

et al. 2023

Chemistry & Biodiversity

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There is need to search substitution of stem bark with leaf of Salix alba L, which is yet not reported. Comparative phytochemicals viz. Salicin, Procyanidin B1 and Catechin were quantified in the heart wood (SA‐HW), stem bark (SA‐SB) and leaves (SA‐L) of Salix alba L.by using newly developed HPLC method. Essential metal ions of all three parts were analysed using newly developed ICP‐OES method, where SA‐L were founded as rich source of micronutrients and essential metal ions as compared to SA‐SB and SA‐HW. GC‐MS/MS analysis has shown the presence of fatty acids and volatile compounds. The observed TPC and TFC values for all three parts were ranged from 2.69 to 32.30 mg GAE/ g of wt. and 37.57 to 220.76 mg QCE/ g of wt. respectively. In DPPH assay the IC50 values of SA‐SB, SA‐HW, and SA‐L were 1.09 (± 0.02), 5.42 (± 0.08), and 8.82 (± 0.10) mg/mL, respectively. The order of antibacterial activities against E. coli, S. aureus, P. aeruginosa, and B. subtilis strains was SA‐L > SA‐HW > SA‐SB with strong antibacterial activities against S. aureus, and B. subtilis strains. The antacid activities order was SA‐L > SA‐SB > SA‐HW.

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Antacid activity of Laportea aestuans (L.) Chew

Cited by 16 publications

References 9 publications

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under‐Utilized Part

A Comparative Analysis of Phytochemicals, Metal Ions, Volatile Metabolites in Heart Wood, Stem Bark and Leaves of Salix alba L. along with in Vitro Antioxidant, Antacid, Antimicrobial Activities for Sake of Environment Conservation by Substitution of Stem Bark With Leaf

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