Antagonism by amantadine of prochlorpemazine-induced catalepsy

1 The effects of the nicotinic cholinoceptor blocking drug, mecamylamine (alone or in combination with morphine or haloperidol) were investigated on the striatal homovanillic acid (HVA) concentration and on the ax-methyl-p-tyrosine (AMPT)induced depletion of striatal or mesolimbic dopamine content in the brain of rats. 2 Mecamylamine (2 mg/kg) alone did not alter the striatal HVA concentration, but it reduced the probenecid-induced accumulation of HVA. Mecamylamine pretreatment reduced the morphineand haloperidol-induced elevation of striatal HVA concentration. Hexamethonium did not alter the striatal HVA concentration when given alone or in probenecid-or morphine-treated rats, whereas pempidine (8 mg/kg) clearly reduced the probenecid-induced accumulation of HVA in the striatunm 3 Mecamylamine (2 and 8 mg/kg) slowed the rate of AMPT-induced depletion of dopamine from the striatum and mesolimbic area both in the brain of control rats and of rats treated with morphine or haloperidol. 4 Mecamylamine slightly prolonged the cataleptic effect of morphine. 5 The results indicate that mecamylamine inhibits the release of dopamine both from the striatal and mesolimbic dopaminergic neurones.

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“…Results have been corrected for losses. Catalepsy was scored as described by Simon, Malatray & Boissier (1970) and by Cashin & Sutton (1973).…”

Section: Introductionmentioning

confidence: 99%

Effect of Mecamylamine on the Fate of Dopamine in Striatal and Mesolimbic Areas of Rat Brain; Interaction With Morphine and Haloperidol

Ahtee

Kaakkola

1978

British J Pharmacology

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“…However, amantadine is devoid of any effect in the tremorine-tremor test (unpublished results by C. Bianclii, 1969 and by W. Price quoted in 15,27).…”

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confidence: 99%

Central Nervous System and Autonomic Nervous System Effects of Amantadine and of Some Standard Anti-Parkinson Drugs

Bianchi¹,

Tomasi²

1973

Pharmacology

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The activity of amantadine HCl, trihexyphenidyl HCl, ethopropazine HCl, atropine sulphate, mecamylamine HCl and L-dopa against effects provoked by nicotine injected intracerebrally(tremors, convulsions, loss of righting reflex) was studied. The antagonistic drugs were injected intraperitoneally or intracerebrally.The above mentioned drugs except L-dopa and atropine preventednicotine manifestations when given intraperitoneally. Amantadine, atropine and mecamylamine, resulted active when given intracerebrally (trihexyphenidyl, ethopropazine and L-dopa could not betested i.e.). Effects provoked by oxotremorine were counteracteby atropine, trihexyphenidyl, ethopropazine but not by amantadineand mecamylamine. Trihexyphenidyl, ethopropazine and atropine had anticarbamylcholine activity and mydriatic activity. Amantadine and mecamylamine were inactive or almost inactive.

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“…During the experiments the rats were kept in individual cages at 20-220 C. Catalepsy was scored as described by Simon, Malatray & Boissier (1970) and by Cashin & Sutton (1973 The rats were killed by decapitation, and the brain was rapidly removed and dissected. The striata from two brains were pooled for the estimation of HVA.…”

Section: Methodsmentioning

confidence: 99%

Inhibition by Apomorphine of the Metoclopramide‐induced Catalepsy and Increase in Striatal Homovanillic Acid Content

Ahtee

1975

British J Pharmacology

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I The mechanism of the cataleptic effect of metoclopramide was analyzed by using drugs which alter the activity of dopaminergic or cholinergic neurones or the content of 'y-aminobutyric acid in the central nervous system of rats.2 The cataleptic effect of metoclopramide (20 mg/kg) was antagonized by apomorphine (10 mg/kg) and by atropine (50 mg/kg). Aminooxyacetic acid (AOAA, 25-50 mg/kg) potentiated the catalepsy induced by metoclopramide (5 mg/kg). 3 Metoclopramide alone did not alter the rectal temperature of rats. It did not alter the AOAA-induced hypothermia, but it partially antagonized apomorphine-induced hypothermia. 4 Metoclopramide induced a six-fold increase in striatal homovanillic acid (HVA) concentration, but it did not change the dopamine or noradrenaline content in the brain of rats. Apomorphine decreased the striatal HVA concentration in control and in metoclopramide-treated rats. Atropine and AOAA did not alter the metoclopramide-induced increase in striatal HVA concentration. 5 The results suggest that metoclopramide produces catalepsy by blocking striatal dopamine receptors.

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Antagonism by amantadine of prochlorpemazine-induced catalepsy

Cited by 45 publications

References 5 publications

Effect of Mecamylamine on the Fate of Dopamine in Striatal and Mesolimbic Areas of Rat Brain; Interaction With Morphine and Haloperidol

Effect of Mecamylamine on the Fate of Dopamine in Striatal and Mesolimbic Areas of Rat Brain; Interaction With Morphine and Haloperidol

Central Nervous System and Autonomic Nervous System Effects of Amantadine and of Some Standard Anti-Parkinson Drugs

Inhibition by Apomorphine of the Metoclopramide‐induced Catalepsy and Increase in Striatal Homovanillic Acid Content

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