Antagonism of detomidine sedation with atipamezole in horses

Ramseyer, B.; Schmucker, N.; Schatzmann, U.; Busato, André; Moens, Yves

doi:10.1111/j.1467-2995.1998.tb00169.x

Cited by 23 publications

(20 citation statements)

References 13 publications

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“…In wild animal capture studies involving α-2 adrenergic sedatives, atipamezole has been successfully employed to accelerate animal recovery and reduce the costs of anaesthesia monitoring (Matthews et al 1995;Ramseyer et al 1998;Hubbell and Muir 2006). However, timing of atipamezole administration is important irrespective of whether an α-2-antagonist is the only drug administered or if it is combined with other sedatives or anaesthetics.…”

Section: Discussionmentioning

confidence: 99%

Assessing the efficacy of medetomidine and tiletamine–zolazepam for remote immobilisation of feral horses (Equus caballus)

et al. 2014

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Methods. Nine feral horses were darted from the ground with 60 mg of medetomidine and 1500 mg of tiletamine-zolazepam. The effects of medetomidine were reversed with 50-100 mg of atipamezole 30-40 minutes post induction (IV/IM). Physiological variables monitored during anaesthesia were heart rate, respiratory rate, temperature and oxygen haemoglobin saturation (S p O 2 ). 2Key results. All horses were successfully immobilised with between one and three darts (n = 9). The mean dose of medetomidine was 0.15 ± 0.01 mg kg -1 (SEM) and tiletaminezolazepam was 3.61 ± 0.16 mg kg -1 . Mean time from darting to lateral recumbency was 13 ± 2.7 min, and mean recumbency time was 54 ± 13 min. Vital signs for all anaesthetised animals remained within normal range during anaesthesia, with the exception of one animal displaying a transient drop in S p O 2 . No mortalities were encountered.Key conclusions. The combination of medetomidine and tiletamine-zolazepam provided adequate anaesthesia in feral horses in the field for application of GPS collars.Implications. Although a limited number of horses were immobilised, this study shows that medetomidine and tiletamine-zolazepam provides effective short-term anaesthesia for feral horses, providing a practical and field-accessible capture technique. This method could also be applied to other management actions requiring safe and humane capture of feral horses.

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Section: Discussionmentioning

confidence: 99%

Assessing the efficacy of medetomidine and tiletamine–zolazepam for remote immobilisation of feral horses (Equus caballus)

et al. 2014

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“…; Ramseyer et al. ; Hubbell & Muir ). MK‐467 is an α 2 ‐adrenoceptor antagonist with poor penetration of the blood–brain barrier and it therefore selectively targets peripherally located α 2 ‐adrenoceptors (Clineschmidt et al.…”

Section: Introductionmentioning

confidence: 99%

“…The a 2 -adrenoceptor antagonist atipamezole has been shown to reverse the cardiovascular effects of a 2 -adrenoceptor agonists in horses in vivo (Raekallio et al 1990;Kamerling et al 1991). As atipamezole readily enters the brain, it also at least reverses partially the desired sedative and analgesic effects of detomidine on the central nervous system (Kamerling et al 1991;Ramseyer et al 1998;Hubbell & Muir 2006). MK-467 is an a 2 -adrenoceptor antagonist with poor penetration of the blood-brain barrier and it therefore selectively targets peripherally located a 2 -adrenoceptors (Clineschmidt et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Pakkanen

Raekallio

Mykkänen

et al. 2015

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Understanding population dynamics of feral horses in the Tuan and Toolara State Forest for successful long-term population management

Zabek¹

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Feral horses (Equus caballus) in Australia are a growing problem despite implementation of management strategies. The increasing number of feral horses within the Tuan and Toolara State Forest (TTSF), a coniferous plantation on the Sunshine Coast, Queensland, and particularly near major public roads, has been recognised as a problem in the last decade. Desensitised to road traffic, horses are a serious distraction for motorists, and have potential to cause serious animal-vehicle accidents.The primary objective of the study was to characterise the essential demographics of the TTSF feral horses, so that the most suitable methods for long-term population management could be determined. The study was conducted from 2012 -2014 and determined social structure, reproductive performance and survival, and population growth rate. The estimation of population distribution, abundance and density together with assessment of habitat use and home range size were also addressed.The studied population did not show significant annual variation in demographics, which is consistent with measurements in other unmanaged feral horse populations in Australia and abroad. The overall size and age composition of social groups remained stable during the study period. The average harem size was estimated as 4.95 (95%CI 4.53-5.41), and usually consisted of 1 stallion, 2 -3 adult females, and 2 immature offspring (≤ 3 years of age). Males not associated with harems consisted of adult (≥ 3 years old) and sub-adult (2 years old) individuals, either forming groups of 2 -6 or living by themselves. The population showed a stable age distribution, with adult horses constituting the largest group (68%; n = 247). The sex ratio of adult female to male horses was nearly equal (0.99:1.00).The mean annual fecundity was 0.23 ± 0.07 SD and was comparable to those obtained for other feral horse populations where the environment imposed nutritional limitations. Adult females were observed to foal on average every second year. The overall nutritional status of the population expressed as body condition score (BCS; 0 -5) was 2.55 ± 0.51 SD with adult females having poorer scores than other age and gender groups. Survival estimates were consistently high (0.92 -0.95) across all age groups. The average annual finite rate of population increase (λ) for the three years of the study was 1.088 which was lower than the maximum reported for populations living in the most favourable conditions. Elasticity iii analysis demonstrated that the TTSF population growth rate was almost seven times more sensitive to changes in adult survival compared with juvenile survival, and almost twice more sensitive than changes in fecundity.Assessment of the population distribution based on a strip transect survey using horse dung on forest tracks indicated that the majority of the forestry was occupied by horses, with the highest population density being located in the central region of the plantation.Abundance and density of horses were estimated by distance line transect surv...

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Antagonism of detomidine sedation with atipamezole in horses

Cited by 23 publications

References 13 publications

Assessing the efficacy of medetomidine and tiletamine–zolazepam for remote immobilisation of feral horses (Equus caballus)

Assessing the efficacy of medetomidine and tiletamine–zolazepam for remote immobilisation of feral horses (Equus caballus)

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Understanding population dynamics of feral horses in the Tuan and Toolara State Forest for successful long-term population management

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