Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test

Heidari-Oranjaghi, Nima; Azhdari-Zarmehri, Hassan; Erami, Elaheh; Haghparast, Abbas

doi:10.1016/j.pbb.2012.08.007

Cited by 43 publications

(21 citation statements)

References 46 publications

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“…Many analgesic substances inhibit only the second phase of the formalin response, including anti-inflammatory drugs (Sarookhani, Ghasemi-Dash-khasan, Heidari-Oranjaghi, Azhdari-Zarmehri, Erami, & Hosseini, 2014), N-methyl-D-aspartate antagonists (Sessle & Hu, 1991; Shamsizadeh, Soliemani & Mohammad-Zadeh, 2014), and morphine (Coderre & Melzack, 1992; Shrestha, Gracias, Mujenda, Khodorova, Vasko & Strichartz, 2009), again indicating that the second phase is driven by local inflammatory mediators in the periphery.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Erami

Azhdari-Zarmehri

Imoto

et al. 2017

BCN

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Introduction:Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin.Methods:In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of the hind limb in adult rats.Results:A typical biphasic nociceptive response was seen after formalin injection into the plantar surface of the hind paw. A brief interphase separates the first and second phases where nociceptive behaviors were barely spotted. However, following subcutaneous injection into the hairy skin nociceptive behaviors were only seen after 10 minutes of formalin injection, which correlates in time with the second phase of the formalin response. First phase nociceptive behaviors were never seen with hairy skin injection, even following multiple injections of formalin.Conclusion:These data suggest that nociceptive behaviors and spinal responses induced by formalin injections to glabrous and hairy skin areas are different, and that the first and second phases may be mediated through different noxious afferent fibers.

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Section: Discussionmentioning

confidence: 99%

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Erami

Azhdari-Zarmehri

Imoto

et al. 2017

BCN

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“…Thus, orexins induced antinociceptive effects in different assays for thermal, mechanical and chemical stimuli (Mobarakeh et al, 2005). OX 1 receptor activation has been classically implicated in the antinociceptive effects of orexins (Jeong and Holden, 2009;Ho et al, 2011;Heidari-Oranjaghi et al, 2012), although a role for OX 2 receptors has also been recently suggested (Azhdari-Zarmehri et al, 2013). The central amygdala could participate in the regulation by orexins of THC-induced antinociception because a reduction in c-Fos expression was observed in PPO KO mice following THC administration.…”

Section: Bjpmentioning

confidence: 99%

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ⁹‐tetrahydrocannabinol

Flores

Julià-Hernández

Maldonado

et al. 2016

British J Pharmacology

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BACKGROUND AND PURPOSEAnatomical, biochemical and pharmacological evidence suggest the existence of a crosstalk between the orexinergic and endocannabinoid systems. While the orexin receptor 1 (OX 1 receptor) modulates the reinforcing properties of cannabinoids, the participation of orexins in the acute pharmacological effects of Δ 9 -tetrahydrocannabinol (THC) remains unexplored. EXPERIMENTAL APPROACHWe assessed the possible role of orexins in THC-induced hypolocomotion, hypothermia, antinociception, anxiolytic-and anxiogenic-like effects and memory impairment. Selective OX 1 and OX 2 receptor antagonists and OX 1 knockout (KO) mice as well as prepro-orexin (PPO) KO mice were used as pharmacological and genetic approaches. CB 1 receptor levels in control and PPO KO mice were evaluated by immunoblot analysis. The expression of c-Fos after THC treatment was analysed in several brain areas in wild-type mice and in mice lacking the PPO gene. KEY RESULTSThe hypothermia, supraspinal antinociception and anxiolytic-like effects induced by THC were modulated by orexins through OX 2 receptor signalling. OX 1 receptors did not seem to be involved in these THC responses. No differences in CB 1 receptor levels were found between wild-type and PPO KO mice. THC-induced increase in c-Fos expression was reduced in the central amygdala, medial preoptic area and lateral septum in these mutant mice. CONCLUSIONS AND IMPLICATIONSOur results provide new findings to further clarify the interaction between orexins and cannabinoids. OX 1 and OX 2 receptors are differently implicated in the pharmacological effects of cannabinoids.Abbreviations DI, discrimination index; KO, knockout; MPE, maximum possible effect; PPO, prepro-orexin; THC, Δ -Tetrahydrocannabinol (THC), the main psychoactive constituent of Cannabis sativa, produces a wide spectrum of central and peripheral actions, including antinociception, hypothermia, immunomodulation, hypolocomotion, catalepsy, memory disruption, rewarding effects and emotional responses (Pertwee, 2008). The CNS responses to THC are mainly mediated by the cannabinoid receptor 1 (CB 1 receptor), which is a member of the family of GPCRs (Pertwee et al., 2010). Thus, the antinociceptive, hypolocomotor and hypothermic effects of THC, as well as the somatic signs of THC withdrawal, were not observed in CB 1 knockout (KO) mice (Ledent et al., 1999). The discovery of CB 2 receptors in neurons of the CNS (Van Sickle et al., 2005) suggests that these receptors could also contribute to some central pharmacological effects of THC. Several heterologous systems, different from the endocannabinoid system, also participate in the behavioural responses induced by THC. Thus, dopamine (Sami et al., 2015), endogenous opioids (Robledo et al., 2008), monoamines (Viñals et al., 2015), GABA (Radhakrishnan et al., 2015), glutamate (Castaldo et al., 2010), ACh (Goonawardena et al., 2010), adenosine (Justinová et al., 2014) and several neuropeptides (Verty et al., 2004) have been shown to be involved in cannabinoid pharmacolo...

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“…A major disadvantage of the commonly used 'pedestal over water' and 'inverted flower pot' methods of sleep disruption is the potential for confounding stress responses (Suchecki et al, 1998;Andersen et al, 2009). As both acute and chronic stress can differentially interfere with pain outcome measurements (Bardin et al, 2009;Botelho et al, 2010;Lafrance et al, 2010;Heidari-Oranjaghi et al, 2012;Spezia Adachi et al, 2012), a low-stress model of sleep disruption may be preferable when studying nociceptive thresholds following reduced sleep. In the present study, we found no significant change in plasma corticosterone levels.…”

Section: Figurementioning

confidence: 99%

Development and pharmacological characterization of a model of sleep disruption‐induced hypersensitivity in the rat

Wodarski

Schuh‐Hofer

Yurek

et al. 2014

European Journal of Pain

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Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test

Cited by 43 publications

References 46 publications

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ⁹‐tetrahydrocannabinol

Development and pharmacological characterization of a model of sleep disruption‐induced hypersensitivity in the rat

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Antagonism of orexin-1 receptors attenuates swim- and restraint stress-induced antinociceptive behaviors in formalin test

Cited by 43 publications

References 46 publications

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ9‐tetrahydrocannabinol

Development and pharmacological characterization of a model of sleep disruption‐induced hypersensitivity in the rat

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Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ⁹‐tetrahydrocannabinol