1994
DOI: 10.1016/0922-4106(94)90109-0
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Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors

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Cited by 92 publications
(44 citation statements)
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“…Presynaptic adenylate cyclase activation has been shown to open N-type Ca 2ϩ channels causing increased influx of Ca 2ϩ and neurotransmitter release (Kemp et al 1994). Thus GHB, by inhibiting adenylate cyclase, could negatively modulate N-type Ca 2ϩ channels on gabaergic and glutamatergic nerve endings and reduce transmitter release (Chavez-Noriega and Stevens 1994; Kemp et al 1994;Dutar and Nicoll 1988).…”
Section: Discussionmentioning
confidence: 99%
“…Presynaptic adenylate cyclase activation has been shown to open N-type Ca 2ϩ channels causing increased influx of Ca 2ϩ and neurotransmitter release (Kemp et al 1994). Thus GHB, by inhibiting adenylate cyclase, could negatively modulate N-type Ca 2ϩ channels on gabaergic and glutamatergic nerve endings and reduce transmitter release (Chavez-Noriega and Stevens 1994; Kemp et al 1994;Dutar and Nicoll 1988).…”
Section: Discussionmentioning
confidence: 99%
“…Dose-dependent inhibitions of adenylyl cyclase activity were observed in the thalamus with selective agonists of these receptor types (8-OH-DPAT, L-AP4; glutamate), and their inhibitory actions were antagonized by the selective 5-HTlA antagonist, pindobind-5-HTIA (Liau et al, 1991), and by the mGluR antagonist, MCPG (selective to mGluR negatively coupled to adenylyl cyclase activity) (Kemp et al, 1994), respectively. In the PAG, where 5-HTlA receptors have also been characterized (Boess & Martin, 1994), a dosedependent inhibition of adenylyl cyclase activity was observed with 8-OH-DPAT, and this was antagonized by the 5-HTlA antagonist.…”
Section: Discussionmentioning
confidence: 99%
“…The principal aim of this study was to compare the recently reported mGluR antagonists MPPG, MTPG and MSPG with the more established mGluR antagonists, MAP4, MCCG and (+)-MCPG Kemp et al, 1994b) on agonist-induced depressions of synaptic transmission in the lateral perforant path of rat hippocampal slices. Initially, we confirmed that our preparation is particularly sensitive to the group III mGluR agonist, L-AP4 (Koerner & Cotman, 1981).…”
Section: Discussionmentioning
confidence: 99%
“…( (MSPG) and (RS)-ca-methyl-4-phosphonophenylglycine (MPPG) were synthesized as described previously Jane et al, 1994;Kemp et al, 1994b). (2S,1'R,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)-glycine (DCG-IV) was kindly provided by Dr Y. Ohfune (Tokyo). All drugs were made up as stock solutions, dissolved in equimolar NaOH at a concentration of at least 100 times the final concentration and were stored in frozen aliquots.…”
Section: Methodsmentioning
confidence: 99%
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