Antagonistic Action of Certain Neurotropic Viruses Toward a Lymphoid Tumor in Chickens with Resulting Immunity.

Sharpless, George R.; Davies, M.C.; Cox, Herald R.

doi:10.3181/00379727-73-17651

Cited by 32 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, oncolysis by arboviruses was followed by solid immunity to several transplantable tumors (24,25). The same was true of onco]ysis by tumor-adapted influenza virus (9,I0,II,26).…”

Section: Discussionmentioning

confidence: 92%

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Lindenmann

Klein

1967

The Journal of Experimental Medicine

215

View full text Add to dashboard Cite

A2G mice could be solidly immunized against the Ehrlich ascites tumor by single intraperitoneal injections of homogenized and lyophilized tumor cells which had been infected with oncolytic strains of influenza A virus. Similar homogenates from noninfected tumor cells were not immunogenic, even when mixed with egg-grown virus. The immunizing principle in viral oncolysates could not be separated from the oncolytic virus by differential centrifugation or adsorption to and elution from red cells. It could be inhibited by antibody raised in rabbits against the egg-grown oncolytic virus. This reaction showed serologic specificity. Thus, the immunogenicity of an oncolysate produced with the WSA strain of neurotropic influenza virus could be inhibited by rabbit anti-WSA, but not by rabbit antibody to the TUR strain of fowl plague virus. Conversely, the immunogenicity of an oncolysate prepared with the TUR strain could be inhibited by rabbit anti-TUR, but not by anti-WSA. When mice were preimmunized (primed) with egg-grown WSA virus, their antitumor response to a later injection of WSA oncolysate was of the anamnestic type. Priming with egg-grown influenza B virus had no such effect. It was concluded that the immunogenicity of certain host cell components was greatly increased by incorporation into the makeup of the oncolytic virus.

show abstract

“…Thus, oncolysis by arboviruses was followed by solid immunity to several transplantable tumors (24,25). The same was true of onco]ysis by tumor-adapted influenza virus (9,I0,II,26).…”

Section: Discussionmentioning

confidence: 92%

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Lindenmann

Klein

1967

The Journal of Experimental Medicine

215

View full text Add to dashboard Cite

show abstract

“…I t is doubtful if the growth rates are the only reason for the differences noted. The viruses may be classified as follows: (1) those which grow in a tumor and do not affect it; (2) those which grow in a tumor and destroy it; and ( 3 ) those which fail to grow in tumors. There are two rather striking examples of this latter situation.…”

Section: Coxsackie (A)mentioning

confidence: 99%

Viruses With Oncolytic Properties and Their Adaptation to Tumors

Moore

1952

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

“…In addition to the EA-influenza virus system described by Lindenmann (21) tumor immunity following viral oncolysis has been reported by others (19,34). However, the basis of such immunity has only been previously defined by Lindenmann (21).…”

Section: Discussionmentioning

confidence: 96%

Antibody-Mediated Immunity to Transplantable Tumors Following Reovirus Oncolysis

Klein

1967

Pathobiology

View full text Add to dashboard Cite

Antagonistic Action of Certain Neurotropic Viruses Toward a Lymphoid Tumor in Chickens with Resulting Immunity.

Cited by 32 publications

References 0 publications

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Viruses With Oncolytic Properties and Their Adaptation to Tumors

Antibody-Mediated Immunity to Transplantable Tumors Following Reovirus Oncolysis

Contact Info

Product

Resources

About