Antagonistic activity of dietary allicin against deltamethrin-induced oxidative damage in freshwater Nile tilapia; Oreochromis niloticus

Abdel-Daim, Mohamed M.; Abdelkhalek, Nevien; Hassan, Ahmed M.

doi:10.1016/j.ecoenv.2014.10.019

Cited by 82 publications

(21 citation statements)

References 58 publications

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“…We found that the expression levels of CYP450 and glutathione metabolism genes were downregulated, which means that CYP450 and glutamathione are relevant to deltamethrin metabolism. Our results were consistent with those of previous studies: Banka et al [ 59 ] found that CYP450 enzymes were inhibited by deltamethrin in vivo and in vitro, and Abdel-Daim et al [ 60 ] revealed that deltamethrin could induce lipid peroxidation and glutathione reduction. However, Erdogan et al [ 61 ] found a significant increase in CYP450 in the muscle of rainbow trout exposed to deltamethrin, and Olsvik et al [ 62 ] reported that the levels of non-enzymatic antioxidant glutathione were increased in all the tissues exposed to deltamethrin.…”

Section: Discussionsupporting

confidence: 94%

“…In our study, we found that the gene involved in the pentose phosphate pathway was upregulated, which indicated that deltamethrin disrupted carbohydrate metabolism. Abdel-Daim et al [ 60 ] showed that serum glucose and cholesterol levels were significantly increased because of deltamethrin toxicity in the Nile tilapia, and El-Sayed & Saad [ 63 ] found that a reduction in hepatic glycogen levels accompanied by an increase in plasma glucose levels was a common reaction against toxic insult followed by metabolic stress in fishes. The hyperglycemic effect after pyrethroid treatment in the Nile tilapia suggests the effects of deltamethrin on the glycolytic and glycogenesis pathways [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

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Transcriptional responses in the hepatopancreas of Eriocheir sinensis exposed to deltamethrin

et al. 2017

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Deltamethrin is an important pesticide widely used against ectoparasites. Deltamethrin contamination has resulted in a threat to the healthy breeding of the Chinese mitten crab, Eriocheir sinensis. In this study, we investigated transcriptional responses in the hepatopancreas of E. sinensis exposed to deltamethrin. We obtained 99,087,448, 89,086,478, and 100,117,958 raw sequence reads from control 1, control 2, and control 3 groups, and 92,094,972, 92,883,894, and 92,500,828 raw sequence reads from test 1, test 2, and test 3 groups, respectively. After filtering and quality checking of the raw sequence reads, our analysis yielded 79,228,354, 72,336,470, 81,859,826, 77,649,400, 77,194,276, and 75,697,016 clean reads with a mean length of 150 bp from the control and test groups. After deltamethrin treatment, a total of 160 and 167 genes were significantly upregulated and downregulated, respectively. Gene ontology terms “biological process,” “cellular component,” and “molecular function” were enriched with respect to cell killing, cellular process, other organism part, cell part, binding, and catalytic. Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes showed that the metabolic pathways were significantly enriched. We found that the CYP450 enzyme system, carboxylesterase, glutathione-S-transferase, and material (including carbohydrate, lipid, protein, and other substances) metabolism played important roles in the metabolism of deltamethrin in the hepatopancreas of E. sinensis. This study revealed differentially expressed genes related to insecticide metabolism and detoxification in E. sinensis for the first time and will help in understanding the toxicity and molecular metabolic mechanisms of deltamethrin in E. sinensis.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Transcriptional responses in the hepatopancreas of Eriocheir sinensis exposed to deltamethrin

et al. 2017

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“…Allicin is a major biologically active component of garlic clove extracts with a potent antioxidant activity [ 11 ]. Moreover, it has been shown to exert organoprotective effects against several xenobiotics, such as deltamethrin and doxorubicin [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Alam

Fawzi

Alkhalf

et al. 2018

Oxidative Medicine and Cellular Longevity

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The present study investigated the efficacy of allicin as an antibacterial, anti-inflammatory, antioxidant, and immunostimulant agent in reducing the severity of Pasteurella multocida (P. multocida) type B infection in rabbits. Fifty New Zealand rabbits, 5 weeks old, were divided equally into five groups. Except for group 1, all groups were intranasally infected with P. multocida type B (2 × 105 colony forming units/ml/rabbit). Then, group 3 rabbits were orally treated with allicin (50 mg/kg BW) for 5 days, group 4 rabbits received a single oral dose of norfloxacin 30% (100 mg/kg BW), while group 5 rabbits were treated with a combination of norfloxacin and allicin. Hematological, serum biochemical, inflammatory cytokine, immunological, and histopathological analyses were performed. Results revealed that rabbits, infected with P. multocida type B, exhibited macrocytic hypochromic anemia and leukocytosis with a significant elevation in the phagocytic percentage and index. Moreover, significant reductions in serum total protein, albumin, globulin, and immunoglobulin (IgG and IgM) levels were observed in infected rabbits. Infected rabbits showed significant increases in serum inflammatory cytokine (TNF-α and IL-6), alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, and serum bilirubin (total, direct, and indirect) levels. Further, P. multocida infection induced oxidative stress as demonstrated by the significant reduction in serum levels of reduced glutathione and superoxide dismutase enzyme and marked elevation in serum malondialdehyde. Treatment with allicin, norfloxacin, or their combination significantly ameliorated the alterations in all studied parameters. In conclusion, allicin could ameliorate the inflammation and oxidative stress, induced by P. multocida type B infection in rabbits.

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“…Purportedly, allicin protects cells against oxidative stress by inducing the production of antioxidant enzymes ( El-Sheakh et al, 2016 ). Previous studies have shown that allicin supplementation improves oxidative stress by increasing activities of CAT and SOD and reducing MDA content in rats ( Abdel-Daim et al, 2017 ), mice ( Panyod et al, 2016 ) and Nile tilapia ( Abdel-Daim et al, 2015 ). In the present study, the specific activities of T-SOD, CuZn-SOD, Mn-SOD and MDA contents were not significantly affected by allicin supplementation, while the specific activity of T-AOC in larvae fed diets with 0.005, 0.01, and 0.02% allicin was significantly higher than the control.…”

Section: Discussionmentioning

confidence: 99%

“…High mortality was one of the important limiting factors during fish larvae culture, and more attention has been paid to enhance larval health to improve the survival rate ( Rojo-Cebreros et al, 2018 ). Allicin has been used as immunostimulants to enhance the immune response in mice ( Bruck et al, 2005 ), chicken ( Wang et al, 2017 ), pig ( Lan et al, 2017 ) and many fish species ( Nya and Austin, 2011 ; Abdel-Daim et al, 2015 ; Xu et al, 2020 ). NO is a key molecule in the immune-neuroendocrine integration cooperating with other molecules in vertebrates ( Pederzoli and Mola, 2016 ), and showed protective roles of immuno-protection against pathogenic infection via regulating Akt and ERK pathway ( Zhou et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary Allicin Improved the Survival and Growth of Large Yellow Croaker (Larimichthys crocea) Larvae via Promoting Intestinal Development, Alleviating Inflammation and Enhancing Appetite

et al. 2020

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A 30-day feeding experiment was conducted to investigate effects of dietary allicin on survival, growth, antioxidant capacity, innate immunity and expression of inflammatory and appetite related genes in large yellow croaker larvae. Four iso-nitrogenous (53% crude protein) and iso-lipidic (19% crude lipid) diets were formulated via supplementing graded levels of allicin (0.0 (the control), 0.005, 0.01, and 0.02% dry diet, respectively). Results showed that, among dietary treatments, larvae fed the diet with 0.005% allicin had the highest survival rate (SR) ( P < 0.05), while larvae fed the diet with 0.01% allicin had the highest specific growth rate (SGR) ( P < 0.05). Activities of α-amylase in both pancreatic (PS) and intestine segments (IS) of larvae fed the diet with 0.01% allicin were significantly lower than that in the control ( P < 0.05). On the other hand, the supplementation of 0.01% allicin in diets significantly increased activities of alkaline phosphatase (AKP) and leucine aminopeptidase (LAP) in the intestinal brush border membrane (BBM) of larvae than the control ( P < 0.05), indicating the promoting roles of allicin on fish larval intestinal development. Moreover, compared to the control, both the nitric oxide (NO) content and the activity of nitric oxide synthase (NOS) were significantly up-regulated in larvae fed the diet with 0.005% allicin, and catalase (CAT) were significantly upregulated in larvae fed the diet with 0.02% allicin ( P < 0.05). Transcriptional levels of pro-inflammatory genes including cyclooxygenase-2 ( cox-2 ), interleukin-1β ( il-1 β) and interleukin-6 ( il-6 ) significantly decreased with increasing allicin, compared to the control. The expression of appetite genes including npy , ghrelin and leptin significantly increased with the prolonged fasting period, and dietary allicin supplementation significantly increased the transcriptional level of neuropeptide Y ( npy ) at 0.01%, while increased the transcriptional level of leptin in larvae at 0.02% dosages ( P < 0.05). These results showed that the supplementation of 0.005% – 0.01% allicin in diets could improve the survival and growth of large yellow croaker larvae probably by promoting intestinal development, alleviating inflammation and enhancing appetite.

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Antagonistic activity of dietary allicin against deltamethrin-induced oxidative damage in freshwater Nile tilapia; Oreochromis niloticus

Cited by 82 publications

References 58 publications

Transcriptional responses in the hepatopancreas of Eriocheir sinensis exposed to deltamethrin

Transcriptional responses in the hepatopancreas of Eriocheir sinensis exposed to deltamethrin

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Dietary Allicin Improved the Survival and Growth of Large Yellow Croaker (Larimichthys crocea) Larvae via Promoting Intestinal Development, Alleviating Inflammation and Enhancing Appetite

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