Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets

Hong, Weizhe; Kim, Dong-Wook; Anderson, David J.

doi:10.1016/j.cell.2014.07.049

Cited by 344 publications

(369 citation statements)

References 65 publications

Supporting

Mentioning

341

Contrasting

Unclassified

Order By: Relevance

“…6B, 7A). Interestingly, we have recently observed similar results following optogenetic stimulation of GABAergic neurons in the medial amygdala (Hong et al 2014), a structure that projects indirectly to VMHvl (Canteras et al 1992(Canteras et al , 1995Swanson 2000). We have also observed scalable control of different defensive behaviors-avoidance, freezing, and flight-following stimulation of a different subpopulation of VMH neurons located in its dorsomedial subdivision (Kunwar et al 2015).…”

Section: Scalable Control Of Social Behavior By Vmhvl Esr1 1 Neuronssupporting

confidence: 56%

“…The foregoing data indicate that artificial activation of VMHvl (and MeApd) neurons at different intensities can evoke different types of social behavior at different thresholds (Hong et al 2014;Lee et al 2014) and that the average spiking rate among VMHvl neurons increases as animals progress from investigative to attack behavior (Lin et al 2011;). Together, these findings raise the intriguing possibility that VMHvl encodes the intensity of an escalating state of arousal, motivation, or drive, in a graded manner according to its level of activity (Fig.…”

Section: Social Behavior Control Centers: Rheostats or Switches?mentioning

confidence: 99%

See 1 more Smart Citation

Internal States and Behavioral Decision-Making: Toward an Integration of Emotion and Cognition

Kennedy

Asahina²,

Hoopfer

et al. 2014

Cold Spring Harb Symp Quant Biol

View full text Add to dashboard Cite

Social interactions, such as an aggressive encounter between two conspecific males or a mating encounter between a male and a female, typically progress from an initial appetitive or motivational phase, to a final consummatory phase. This progression involves both changes in the intensity of the animals' internal state of arousal or motivation and sequential changes in their behavior. How are these internal states, and their escalating intensity, encoded in the brain? Does this escalation drive the progression from the appetitive/motivational to the consummatory phase of a social interaction and, if so, how are appropriate behaviors chosen during this progression? Recent work on social behaviors in flies and mice suggests possible ways in which changes in internal state intensity during a social encounter may be encoded and coupled to appropriate behavioral decisions at appropriate phases of the interaction. These studies may have relevance to understanding how emotion states influence cognitive behavioral decisions at higher levels of brain function.

show abstract

Section: Scalable Control Of Social Behavior By Vmhvl Esr1 1 Neuronssupporting

confidence: 56%

Section: Social Behavior Control Centers: Rheostats or Switches?mentioning

confidence: 99%

Internal States and Behavioral Decision-Making: Toward an Integration of Emotion and Cognition

Kennedy

Asahina²,

Hoopfer

et al. 2014

Cold Spring Harb Symp Quant Biol

View full text Add to dashboard Cite

show abstract

“…On the other hand, ERα silencing in the medial amygdala (MeA) did not affect either behavior (9), contrary to our predictions. Numerous studies have shown that neurons in the MeA express a high level of ERα (10)(11)(12) and play a role in the facilitation of both male sexual and aggressive behaviors (13)(14)(15)(16)(17)(18). However, consistent with our findings, Paisley et al (19) reported that the site-specific suppression of ERα with antisense in the MeA did not affect the expression of sexual behavior in gonadally intact male rats.…”

contrasting

confidence: 43%

“…Our findings showing a reduced number of MeA neurons in the MeA-αERKD group suggest that the presence of ERα is required for testosterone to masculinize the neuronal number in the MeA during the pubertal period. The importance of the MeA in the regulation of male-type social behaviors has been demonstrated in numerous studies (13)(14)(15)(16)(17)(18). Particularly, the MeA plays a significant role in chemosensory information processing (15,16,33,34) as part of the social behavior network in the CNS (35).…”

Section: Discussionmentioning

confidence: 99%

Pubertal activation of estrogen receptor α in the medial amygdala is essential for the full expression of male social behavior in mice

Sato

Nakata

Musatov

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Testosterone plays a central role in the facilitation of male-type social behaviors, such as sexual and aggressive behaviors, and the development of their neural bases in male mice. The action of testosterone via estrogen receptor (ER) α, after being aromatized to estradiol, has been suggested to be crucial for the full expression of these behaviors. We previously reported that silencing of ERα in adult male mice with the use of a virally mediated RNAi method in the medial preoptic area (MPOA) greatly reduced sexual behaviors without affecting aggressive behaviors whereas that in the medial amygdala (MeA) had no effect on either behavior. It is well accepted that testosterone stimulation during the pubertal period is necessary for the full expression of male-type social behaviors. However, it is still not known whether, and in which brain region, ERα is involved in this developmental effect of testosterone. In this study, we knocked down ERα in the MeA or MPOA in gonadally intact male mice at the age of 21 d and examined its effects on the sexual and aggressive behaviors later in adulthood. We found that the prepubertal knockdown of ERα in the MeA reduced both sexual and aggressive behaviors whereas that in the MPOA reduced only sexual, but not aggressive, behavior. Furthermore, the number of MeA neurons was reduced by prepubertal knockdown of ERα. These results indicate that ERα activation in the MeA during the pubertal period is crucial for male mice to fully express their male-type social behaviors in adulthood.T estosterone plays a central role in the regulation of male-type social behaviors in many mammalian species. It is known that testosterone facilitates the expression of sexual and aggressive behaviors through two kinds of actions. During the developmental period, testosterone exerts its "organizational action" to irreversibly masculinize the sexually undifferentiated brain and build the male-type neural network. In adulthood, testosterone exerts "activational action" to regulate the function of the fully masculinized neural network. As well as acting through androgen receptors (ARs), testosterone also acts through estrogen receptor (ER) α or ERβ, after being aromatized to estradiol (E2). Because the expression of sexual and aggressive behaviors is greatly reduced in aromatase knockout (ArKO) and ERα knockout (αERKO) male mice, aromatization of testosterone and its action via ERα have been suggested to be crucial for the facilitation of male-type social behaviors in mice (1-8). However, the exact timing and brain site(s) of ERα activation crucial for the expression of sexual and aggressive behaviors remain undetermined.In our previous study, we demonstrated site-specific involvement of ERα in the activational action of testosterone by using a virally mediated RNAi method. In this study, knocking down of ERα in the medial preoptic area (MPOA) of gonadally intact adult male mice suppressed sexual behavior while in the ventromedial nucleus (VMN) of hypothalamus reduced both sexual and aggressive behaviors...

show abstract

“…Several cortical and subcortical brain regions have been implicated in controlling social behavior, such as the prefrontal cortex, amygdala, striatum, dorsal raphe, and hypothalamus (Gingrich et al 2000;Young et al 2001;Leypold et al 2002;Robinson et al 2002;Liu and Wang 2003;Young and Wang 2004;Curtis and Wang 2005;Aragona et al 2006;Lin et al 2011;Robinson et al 2011;Dölen et al 2013;Yang et al 2013;Felix-Ortiz and Tye 2014;Hong et al 2014;Unger et al 2015). In rodents, the majority of these studies have focused on sociosexual behaviors, such as pair bonding, aggression, and other behaviors related to sexual competition.…”

mentioning

confidence: 99%

Dopaminergic Dynamics Contributing to Social Behavior

Gunaydin

Deisseroth

2014

Cold Spring Harb Symp Quant Biol

View full text Add to dashboard Cite

Social interaction is a complex behavior that is essential for the survival of many species, and it is impaired in a broad range of neuropsychiatric disorders. Several cortical and subcortical brain regions have been implicated in a variety of sociosexual behaviors, with pharmacological studies pointing to a key role of the neurotransmitter dopamine. However, little is understood about the real-time circuit dynamics causally underlying social interaction. Here, we consider current knowledge on the role of brain reward circuitry in same-sex social behavior and describe findings from new methods for probing how this circuitry governs social motivation in health and disease.

show abstract

Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets

Cited by 344 publications

References 65 publications

Internal States and Behavioral Decision-Making: Toward an Integration of Emotion and Cognition

Internal States and Behavioral Decision-Making: Toward an Integration of Emotion and Cognition

Pubertal activation of estrogen receptor α in the medial amygdala is essential for the full expression of male social behavior in mice

Dopaminergic Dynamics Contributing to Social Behavior

Contact Info

Product

Resources

About