Antagonistic Effect of A.C.T.H. and Cortisone on the Anticoagulant Activity of Ethyl Biscoumacetate

Effect of Oral Corticosteroids on Chronic Warfarin Therapy

“…A case report published in 1954 described a patient anticoagulated with ethyl biscoumacetate who experienced increased prothrombin activity following cortisone therapy. 4 This patient required an increase in the oral anticoagulation dose to reestablish a therapeutic concentration. An early study evaluated the effects of a single oral dose of prednisone 10 mg in 24 patients receiving dicumarol.…”

Deep Vein Thrombosis: A Side Effect of Steroid Therapy

“…Deep venous thrombosis as a complication of steroid therapy was first pointed out by Cosgriff in 1950. Since then there have been several reports of association of deep vein thrombosis and Corticosteroid therapy 5,6 . Mukjerjee et al in 1970 described several cases of deep vein thrombosis in children receiving intermittent Corticosteroids in high dosage for nephrotic syndrome.…”

“…Spontaneous forms are associated with either underlying disease such as malignancy of the pancreas or other organs. Corticosteroid therapy has been implicated as a precipitating factor in deep vein thrombosis by various workers 3,4,5,6 . However, in these cases where association of DVT and Steroid therapy has been described thrombosis involved renal veins or veins of lower rather than upper extremities.…”

Corticotrophin Intravenous Infusion Therapy in Rheumatic Conditions

“…Rawls (1951), in a large series of patients treated with ordinary corticotrophin or cortisone, found the incidence to be 3%. Ragan (1952) and Chatterjea and Salomon (1954) also have drawn attention to the development of thrombo-embolic phenomena. During corticotrophin or cortisone therapy, Cosgriff et al (1950) and Cosgriff (1951) observed an increased coagulability of the blood, which persisted for several weeks after withdrawal.…”