Antagonistic Effect of Selenium on Fumonisin B1 Promotes Neutrophil Extracellular Traps Formation in Chicken Neutrophils

Zhu, Huquan; Qiao, Yuhui; Ouyang, Huimin; Zhang, Ruofan; Li, Jinhong; Xian, Runxi; Wang, Kai; Li, Xinran; Cao, Changyu

doi:10.1021/acs.jafc.2c01329

Cited by 9 publications

(6 citation statements)

References 53 publications

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“…Previous studies have shown that Se antagonizes mycotoxin-induced immune suppression in vitro. − Dietary supplements containing Se are primarily derived from inorganic sources, wherefore 0.2 mg/kg BW Na 2 SeO 3 was selected for this experiment.…”

Section: Discussionmentioning

confidence: 99%

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Zhang

Han²,

Song

et al. 2023

J. Agric. Food Chem.

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The T-2 toxin is one of the most frequent contaminants in the environment and agricultural production globally. It exerts a wide range of toxic effects. Selenium (Se), as an antioxidant, has the potential to be widely used to antagonize mycotoxin toxicity. To investigate the protective effects of Se on bone microenvironment (BM)-related hematopoiesis and immunity after T-2 toxin exposure, 36 male mice were treated with the T-2 toxin (1 mg/kg) and/or Se (0.2 mg/kg) by intragastric administration for 28 days. The results showed that Se alleviated T-2 toxin-induced cytopenia and splenic extramedullary hematopoiesis. Se also significantly relieved T-2 toxin-induced immunosuppression, as assessed by immune factors and lymphocytes. Furthermore, Se also attenuated oxidative stress and apoptosis and improved the BM in T-2 toxin-exposed mice. Therefore, Se improves BM-related hematopoiesis and immunity after T-2 toxin exposure. This study provides references for identifying the toxic mechanism and screening potential therapeutic drugs of the T-2 toxin.

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Section: Discussionmentioning

confidence: 99%

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Zhang

Han²,

Song

et al. 2023

J. Agric. Food Chem.

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“…Usually, the method of oral SeNP administration is used in studies on the influence of the source of Se on the functions of immune cells ([ 18 , 27 , 28 , 48 ] and many others). On the other hand, injections are also used to avoid loss and settling of highly reactive SeNPs in the digestive tract.…”

Section: Discussionmentioning

confidence: 99%

“…Fumonisin B1 has been shown to inhibit zymosan-induced NET formation in chicken neutrophils, preventing ROS burst and release of histone H3 and neutrophil elastase (NE). The addition of Se reduces the toxic effects of fumonisin B1 and restores NET formation, indicating that Se could be used as a potential drug to prevent fumonisin B1 toxicity in livestock [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo

Mal’tseva

Gudkov

Turovsky

2022

IJMS

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This study aimed to discover the immunomodulatory effect of selenium nanoparticles (SeNPs) on the functional state of neutrophils in vivo. Intraperitoneal injections of SeNPs (size 100 nm) 2.5 mg/kg/daily to BALB/c mice for a duration of 7–28 days led to the development of an inflammatory reaction, which was registered by a significant increase in the number of neutrophils released from the peritoneal cavity, as well as their activated state, without additional effects. At the same time, subcutaneous injections of the same SeNPs preparations at concentrations of 0.1, 0.5, and 2.5 mg/kg, on the contrary, modulated the functional state of neutrophils depending on the concentration and duration of SeNPs administration. With the use of fluorescence spectroscopy, chemiluminescence, biochemical methods, and PCR analysis, it was found that subcutaneous administration of SeNPs (0.1, 0.5, and 2.5 mg/kg) to mice for a short period of time (7–14 days) leads to modification of important neutrophil functions (adhesion, the number of migrating cells into the peritoneal cell cavity, ROS production, and NET formation). The obtained results indicated the immunostimulatory and antioxidant effects of SeNPs in vivo during short-term administration, while the most pronounced immunomodulatory effects of SeNPs were observed with the introduction of a low concentration of SeNPs (0.1 mg/kg). Increase in the administration time of SeNPs (0.1 mg/kg or 2.5 mg/kg) up to 28 days led to a decrease in the adhesive abilities of neutrophils and suppression of the expression of mRNA of adhesive molecules, as well as proteins involved in the generation of ROS, with the exception of NOX2; there was a tendency to suppress gene expression pro-inflammatory factors, which indicates the possible manifestation of immunosuppressive and anti-inflammatory effects of SeNPs during their long-term administration. Changes in the expression of selenoproteins also had features depending on the concentration and duration of the administered SeNPs. Selenoprotein P, selenoprotein M, selenoprotein S, selenoprotein K, and selenoprotein T were the most sensitive to the introduction of SeNPs into the mouse organism, which indicates their participation in maintaining the functional status of neutrophils, and possibly mediated the immunomodulatory effect of SeNPs.

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“…Fumonisin B1 (FB1) is a carcinogenic mycotoxin that is present in food and can cause health threats to animals or humans [ 48 – 50 ]. Yu et al developed a colorimetric assay for the detection of FB1 (Fig.…”

Section: Introductionmentioning

confidence: 99%

Promising instrument-free detections of various analytes using smartphones with Spotxel® Reader

et al. 2022

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In consideration of the problems related to food safety, environmental pollution, and the spread of infected diseases nowadays, we urgently need testing methods that can be easily performed by common people. Smartphone-based detections are promising for general applications. However, some of these analytical strategies require a combination of accessories and instruments, such as portable electrochemical workstations, mini multi-mode microplate readers, and complex temperature control devices, etc., which are small but still expensive. Herein, we comprehensively introduce a free app (Spotxel ® Reader) that can provide accurate data analysis for microplate or parallel-format test sensors without an instrument. By simulating the optical signal of the test samples through a smartphone, the sensing results can be obtained for free. We discuss the detection strategies involved in the reported smartphone-based analyses using Spotxel ® Reader. Prospects for the development of this free app for future detection applications are presented. This review aims to popularize free analysis software, so that ordinary people may realize convenient tests. Graphical abstract

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Antagonistic Effect of Selenium on Fumonisin B1 Promotes Neutrophil Extracellular Traps Formation in Chicken Neutrophils

Cited by 9 publications

References 53 publications

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo

Promising instrument-free detections of various analytes using smartphones with Spotxel® Reader

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