2018
DOI: 10.1111/evo.13569
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Antagonistic pleiotropy for carbon use is rare in new mutations

Abstract: Pleiotropic effects of mutations underlie diverse biological phenomena such as ageing and specialization. In particular, antagonistic pleiotropy (“AP”: when a mutation has opposite fitness effects in different environments) generates tradeoffs, which may constrain adaptation. Models of adaptation typically assume that AP is common - especially among large-effect mutations - and that pleiotropic effect sizes are positively correlated. Empirical tests of these assumptions have focused on de novo beneficial mutat… Show more

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Cited by 33 publications
(67 citation statements)
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“…We showed that an intestinal L. reuteri isolate subjected to 150 passes in milk gained proficiency to grow in this substrate but lost aptitude to grow in MRS medium and possibly in murine intestines (table 1). Our results are in agreement with previous studies showing that adaptation to a new ecosystem reduces the fitness in the original ecosystem, a phenomenon known as antagonistic pleiotropy (22, 24, 26). This finding is also in agreement with previous reports indicating that commercial probiotic bacteria (originated from intestines), failed to colonize mammalian intestines (27).…”
Section: Discussionsupporting
confidence: 93%
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“…We showed that an intestinal L. reuteri isolate subjected to 150 passes in milk gained proficiency to grow in this substrate but lost aptitude to grow in MRS medium and possibly in murine intestines (table 1). Our results are in agreement with previous studies showing that adaptation to a new ecosystem reduces the fitness in the original ecosystem, a phenomenon known as antagonistic pleiotropy (22, 24, 26). This finding is also in agreement with previous reports indicating that commercial probiotic bacteria (originated from intestines), failed to colonize mammalian intestines (27).…”
Section: Discussionsupporting
confidence: 93%
“…When bacteria adapt to a new environment, they lose the skills necessary to thrive in the original niche (19). Numerous evolutionary studies have been designed to understand how populations adapt to new specific environmental conditions, like nutrients, temperature, parasites, competition and other environmental stressors (2024). It is assumed that most adaptations to the new condition are associated with the loss of adaptation to the original (20, 24).…”
Section: Introductionmentioning
confidence: 99%
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“…To further test that the high frequency of TF mutations in non-mutator populations were due to positive selection, we analyzed one of the very few MA studies to have sequenced isolates at multiple time points (47). ~36 clones were sequenced at 6 time points spanning ~8,000 generations.…”
Section: The Relative Frequency Of Mutations In Tfs Decline Over mentioning
confidence: 99%
“…The term ‘trade-off’ has been used in a variety of contexts in evolutionary studies (Agrawal et al , 2010), with the following three main usages: (1) when a trait that is adaptive in a given environment is costly (maladaptive or detrimental to fitness) in others (Bell and Reboud, 1997; Kassen, 2014; Rodríguez-Verdugo et al , 2014; Sane et al , 2018); (2) unequal adaptation to alternative environments, wherein populations become adapted to all the environments under consideration but no single genotype can be the fittest one in all the environments (Bell and Reboud, 1997; Remold, 2012; Kassen, 2014); (3) life-history trade-offs across traits that arise within a single environment due to the systemic properties and constraints of organismal features (Stearns, 1989; Prasad et al , 2001; Knops et al , 2007). The first two of the above usages pertain to trade-offs in fitness across environments, which can directly give rise to ecological specialization.…”
Section: Introductionmentioning
confidence: 99%