2013
DOI: 10.1242/jcs.122515
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Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation

Abstract: Summary FBP17, an F-BAR domain protein, has emerged as a crucial factor linking the plasma membrane to WASP-mediated actin polymerization. Although it is well established that FBP17 has a powerful self-polymerizing ability that promotes actin nucleation on membranes in vitro, knowledge of inhibitory factors that counteract this activity in vivo is limited. Here, we demonstrate that the assembly of FBP17 on the plasma membranes is antagonized by PSTPIP2, another F-BAR protein implicated in auto-inflammatory dis… Show more

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Cited by 31 publications
(20 citation statements)
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“…The conserved cDC1 signature encompasses genes with known contribution in the biology of this lineage, such as XCR1 , FLT3 , and CADM1 (59), as well as additional genes which biological function in this subset remains enigmatic, such as the germinal center B-cell-expressed transcript 2 protein ( GCET2 ), the WDFY family member 4 ( WDFY4 ) whose polymorphism is associated to autoimmune diseases (62), and two intracellular trafficking proteins, a formin-binding protein ( FNBP1 ) (63) and Sorting Nexin-22 ( SNX22 ) (64) (Table 1). The conserved cDC1 vs. (pDC and cDC2) relative signature provides a longer list of genes belonging to an interaction network that includes BCL6 , a transcriptional repressor that was recently found involved in the specification of cDC1 (17) as well as XCR1 and CALM1 (Figure 9E).…”
Section: Resultsmentioning
confidence: 99%
“…The conserved cDC1 signature encompasses genes with known contribution in the biology of this lineage, such as XCR1 , FLT3 , and CADM1 (59), as well as additional genes which biological function in this subset remains enigmatic, such as the germinal center B-cell-expressed transcript 2 protein ( GCET2 ), the WDFY family member 4 ( WDFY4 ) whose polymorphism is associated to autoimmune diseases (62), and two intracellular trafficking proteins, a formin-binding protein ( FNBP1 ) (63) and Sorting Nexin-22 ( SNX22 ) (64) (Table 1). The conserved cDC1 vs. (pDC and cDC2) relative signature provides a longer list of genes belonging to an interaction network that includes BCL6 , a transcriptional repressor that was recently found involved in the specification of cDC1 (17) as well as XCR1 and CALM1 (Figure 9E).…”
Section: Resultsmentioning
confidence: 99%
“…PSTPIP2 is tyrosine phosphorylated within 30 sec and inhibits actin polymerization and the ruffling response (Chitu et al 2005). By competing with other F-BAR family proteins for phosphatidylinositol 4,5-bisphosphate (PIP2)-rich membrane-binding sites and recruiting PTPN12 to those sites, PSTPIP2 may mediate the local dephosphorylation and par-tial inactivation of WASP (Cote et al 2002;Tsujita et al 2013).…”
Section: Csf-1 Receptor Signaling In Myeloid Cellsmentioning
confidence: 99%
“…Some BAR family proteins act as tumor suppressors. F-BAR-only protein, PSTPIP2, antagonizes actin polymerization in the podosome by competing with FBP17 at the membrane (302). Furthermore, the I-BAR containing protein MIM is present in normal tissues, but is missing in several metastatic cell lines, and this downregulation is associated with the progression of bladder transitional carcinomas (316).…”
Section: A Cancermentioning
confidence: 99%