Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

Hukema, Renate K.; Rademakers, Suzanne; Dekkers, Martijn; Burghoorn, Jan; Jansen, Gert

doi:10.1038/sj.emboj.7600940

Cited by 98 publications

(161 citation statements)

References 60 publications

Supporting

Mentioning

155

Contrasting

Order By: Relevance

“…One of the conclusions from these results is that multiple CRs expressed in a given cell type converge onto a common set of downstream signal transduction molecules. For example, a number of sensory neuron-specific Gα proteins appear to act in a complex manner to activate or inhibit signaling upon interaction of any ligand with its cognate CR in a given cell type [19,57,[138][139][140]. These G proteins act via different signaling pathways in different chemosensory neuron types.…”

Section: The Molecules For Taste and Smellmentioning

confidence: 99%

“…These experiencedependent modulation of adaptation behaviors likely requires integration and processing of information at downstream loci in chemosensory neural circuits [164,165]. However, cell-cell communication between different chemosensory neurons may also play a role in the regulation of responses to a chemical after prolonged exposure [138] (Fig. 3b).…”

Section: Modulation Of Chemosensory Behaviorsmentioning

confidence: 99%

See 1 more Smart Citation

Generation and modulation of chemosensory behaviors in C. elegans

Sengupta

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

C. elegans recognizes and discriminates among hundreds of chemical cues using a relatively compact chemosensory nervous system. Chemosensory behaviors are also modulated by prior experience and contextual cues. Because of the facile genetics and genomics possible in this organism, C. elegans provides an excellent system in which to explore the generation of chemosensory behaviors from the level of a single gene to the motor output. This review summarizes the current knowledge on the molecular and neuronal substrates of chemosensory behaviors and chemosensory behavioral plasticity in C. elegans.

show abstract

Section: The Molecules For Taste and Smellmentioning

confidence: 99%

Section: Modulation Of Chemosensory Behaviorsmentioning

confidence: 99%

Generation and modulation of chemosensory behaviors in C. elegans

Sengupta

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…Chemotaxis to salt is known to be altered by prior treatment with salt in a paradigm called either gustatory plasticity or salt chemotaxis learning (Saeki et al, 2001;Hukema et al, 2006;Tomioka et al, 2006). Interestingly, treatment of C. elegans in a salt-containing buffer causes a change of chemotaxis from attraction to avoidance of salt.…”

Section: Salt Chemotaxis Learning Causes Reversed Responsesmentioning

confidence: 99%

Parallel Use of Two Behavioral Mechanisms for Chemotaxis inCaenorhabditis elegans

Iino

Yoshida²

2009

J. Neurosci.

254

361

View full text Add to dashboard Cite

Caenorhabditis elegans shows chemotaxis to various odorants and water-soluble chemoattractants such as NaCl. Previous studies described the pirouette mechanism for chemotaxis, in which C. elegans quickly changes the direction of locomotion by using a set of stereotyped behaviors, a pirouette, in response to a decrease in the concentration of the chemical. Here, we report the discovery of a second mechanism for chemotaxis, called the weathervane mechanism. In this strategy animals respond to a spatial gradient of chemoattractant and gradually curve toward higher concentration of the chemical. By computer simulation, we find that both of these mechanisms contribute to chemotaxis and both mechanisms need to act in parallel for efficient chemotaxis. Using laser ablation of individual neurons to examine the underlying neural circuit, we find the ASE sensory neurons and AIZ interneurons are essential for both the pirouette and weathervane mechanisms in chemotaxis to NaCl. Salt-conditioned animals show reversed responses in both of these behaviors, leading to avoidance of NaCl. These results provide a platform for detailed molecular and cellular analyses of chemotaxis and its plasticity in this model organism.

show abstract

“…Saeki et al (2001) showed that learned aversion to NaCl generalized to other water-soluble attractants sensed by ASE, including cAMP, biotin, and lysine, suggesting that the changes were occurring at the cellular rather than the receptor level. Using a modified assay in which worms were soaked in a salt buffer without food for just 15 min, Jansen et al (2002) and Hukema et al (2006) identified several components of the molecular pathways acting in at least four sensory neurons to mediate learned NaCl aversion. Relevant molecules include Gg subunit GPC-1, Ga subunits GPA-1 and ODR-3, and TRPV channel subunits OCR-1, OCR-2, and OSM-9.…”

Section: Taste As the Conditioned Stimulusmentioning

confidence: 99%

An elegant mind: Learning and memory in Caenorhabditis elegans

Ardiel¹,

Rankin²

2010

Learn. Mem.

281

191

View full text Add to dashboard Cite

This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.Historically, it was believed that even if they were capable of learning, the nervous systems of invertebrates were too different to be instructive on human cognition. In the 1960s, Kandel and colleagues began studying learning in the marine mollusc Aplysia (Kandel and Tauc 1965). Using this system, they were able to relate behavioral plasticity to changes at specific synapses of identified neurons, and began a biochemical analysis of these neuronal changes, uncovering a role for cAMP, PKA, and CREB. In the 1970s, Benzer and colleagues began a genetic dissection of learning in the fruit fly Drosophila melanogaster (Quinn et al. 1974;Dudai et al. 1976). They established an associative learning assay (Quinn et al. 1974) and conducted a forward genetic screen, identifying the first learning mutant, dunce (Dudai et al. 1976). Since then, many genes have been cloned, and the biological basis of learning has proven to be highly conserved (Barco et al. 2006;Skoulakis and Grammenoudi 2006). Today there is no question as to the relevance of invertebrate research in the field of learning and memory.At about the same time that Kandel was beginning his work with Aplysia, Sydney Brenner chose Caenorhabditis elegans as the organism in which to study development and the nervous system (Brenner 1974). Today this transparent nematode is the world's best understood animal. It's small size ( 1 mm), short life cycle (,3 d), and ease of cultivation make it perfect for the laboratory, and its mode of reproduction is ideal for genetic analysis-selffertilizing hermaphrodites can be easily inbred or crossed with males. The genome has been mapped and sequenced, and there are thousands of mutants and RNAi constructs readily available for researchers. Furthermore, C. elegans has an invariant cell lineage and relatively simple morphology-959 cells make up the entire adult hermaphrodite (Sulston and Horvitz 1977;Sulston et al. 1983). Using serial section electron micrographs, White et al. (1986) were able to construct a neural wiring diagram of the hermaphrodite's 302 neurons. They found about 5000 chemical synapses, 600 gap junctions, and 2000 neuromuscular junctions, the location of which were fairly consistent between animals. With its invariant cell lineage and reproducible connectome, C. elegans was initially viewed as a genetically hardwired ...

show abstract

Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

Cited by 98 publications

References 60 publications

Generation and modulation of chemosensory behaviors in C. elegans

Generation and modulation of chemosensory behaviors in C. elegans

Parallel Use of Two Behavioral Mechanisms for Chemotaxis inCaenorhabditis elegans

An elegant mind: Learning and memory in Caenorhabditis elegans

Contact Info

Product

Resources

About