Antagonistic Signaling by Caronte , a Novel Cerberus -Related Gene, Establishes Left–Right Asymmetric Gene Expression

Yokouchi, Yuji; Vogan, Kyle; Pearse, Richard V.; Tabin, Clifford J.

doi:10.1016/s0092-8674(00)80045-8

Cited by 164 publications

(160 citation statements)

References 31 publications

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“…Rather, Cerberus-related proteins are key regulators of Nodal signaling and play an important role in the establishment of left -right asymmetry in the vertebrate embryo (Rodriguez Esteban et al 1999;Yokouchi et al 1999;Zhu et al 1999;Hashimoto et al 2004;Marques et al 2004;Tavares et al 2007;Vonica and Brivanlou 2007).…”

Section: Cerberusmentioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

537

450

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Section: Cerberusmentioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

537

450

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“…Cerberus is expressed in the organizer region of Xenopus gastrula stage embryos (Bouwmeester et al 1996) and can serve as an antagonist of Wnt, BMP, and nodal signaling (Glinka et al 1997;Hsu et al 1998;Piccolo et al 1999). Chick cerberus-1/ caronte is expressed in anterior hypoblast and anterior endoderm but is down-regulated in endoderm by stage 4 (Rodriguez Esteban et al 1999;Yokouchi et al 1999;Zhu et al 1999), whereas the heart-inducing capacity of endoderm is retained in this tissue until at least stage 8 − (G. Di Rocco and A.B. Lassar, unpubl.).…”

Section: Other Candidate Heart-inducing Factorsmentioning

confidence: 99%

Inhibition of Wnt activity induces heart formation from posterior mesoderm

Marvin¹,

Rocco²,

Gardiner³

et al. 2001

Genes Dev.

539

459

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In the chick, heart mesoderm is induced by signals from the anterior endoderm. Although BMP-2 is expressed in the anterior endoderm, BMP activity is necessary but not sufficient for heart formation. Previous work from our lab has suggested that one or more additional factors from anterior endoderm are required. Crescent is a Frizzled-related protein that inhibits Wnt-8c and is expressed in anterior endoderm during gastrulation. At the same stages, expression of Wnt-3a and Wnt-8c is restricted to the primitive streak and posterior lateral plate, and is absent from the anterior region where crescent is expressed. Posterior lateral plate mesoderm normally forms blood, but coculture of this tissue with anterior endoderm or infection with RCAS-crescent induces formation of beating heart muscle and represses formation of blood. Dkk-1, a Wnt inhibitor of a different protein family, similarly induces heart-specific gene expression in posterior lateral plate mesoderm. Furthermore, we have found that ectopic Wnt signals can repress heart formation from anterior mesoderm in vitro and in vivo and that forced expression of either Wnt-3a or Wnt-8c can promote development of primitive erythrocytes from the precardiac region. We conclude that inhibition of Wnt signaling promotes heart formation in the anterior lateral mesoderm, whereas active Wnt signaling in the posterior lateral mesoderm promotes blood development. We propose a model in which two orthogonal gradients, one of Wnt activity along the anterior-posterior axis and the other of BMP signals along the dorsal-ventral axis, intersect in the heart-forming region to induce cardiogenesis in a region of high BMP and low Wnt activity.

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“…Whole-mount in situ hybridization and in situ hybridization of tissue sections were performed as described previously (Yokouchi et al 1999). RNA probes for Albumin, CK19, Hhex, and Fibrinogen-␥ were prepared as described previously (Yanai et al, 2005).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

“…The GFP viral construct was described previously (Yokouchi et al, 1999). The cDNA encoding a constitutively active form of mouse FGFR3 (FGFR3CA; kindly provided by Dr. Shimamura) was cloned in-frame with the first ATG of the pSLAX-13 shuttle vector, and transferred as a ClaI fragment to the RCAS(A) retroviral vector.…”

Section: Rcas Virus Construction and Infectionmentioning

confidence: 99%

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

Yanai

Tatsumi

Hasunuma

et al. 2008

Developmental Dynamics

Self Cite

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Intrahepatic bile ducts (IHBDs) are indispensable for transporting bile secreted from hepatocytes to the hepatic duct. The biliary epithelial cells (BECs) of the IHBD arise from bipotent hepatoblasts around the portal vein, suggesting the portal mesenchyme is essential for their development. However, except for Notch or Activin/ TGF-␤ signaling molecules, it is not known which molecules regulate IHBD development. Here, we found that FGF receptors and BMP4 are specifically expressed in the developing IHBD and the hepatic mesenchyme, respectively. Using a mesenchyme-free culture of liver bud, we showed that bFGF and FGF7 induce the hepatoblasts to differentiate into BECs, and that BMP4 enhances bFGF-induced BEC differentiation. The extracellular matrix (ECM) components in the hepatic mesenchyme induced BEC differentiation. Forced expression of a constitutively active form of the FGF receptor partially induced BEC differentiation markers in vivo. These data strongly suggest that bFGF and FGF7 promote BEC differentiation cooperatively with BMP4 and ECMs in vivo.

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Antagonistic Signaling by Caronte , a Novel Cerberus -Related Gene, Establishes Left–Right Asymmetric Gene Expression

Cited by 164 publications

References 31 publications

Secreted and Transmembrane Wnt Inhibitors and Activators

Secreted and Transmembrane Wnt Inhibitors and Activators

Inhibition of Wnt activity induces heart formation from posterior mesoderm

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

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