The Columbia River Flood Basalts and the North Atlantic Igneous Province are two of the youngest Large Igneous Provinces (LIPs) and both are associated with perturbations of the global carbon-cycle. Here we explore the link between the emplacement and eruption of LIPs and their associated carbon-cycle and climatic responses. The emplacement of both LIPs are associated with two well-known climate events: the Monterey Carbon Isotope Excursion (MCIE; ~17-13.5 Ma) and the Paleocene-Eocene Thermal Maximum (PETM; ~56 Ma) characterized by a positive 1‰ and negative 3-5‰ carbon isotope excursion, respectively. Both are also associated with signifi cant global warming. However, despite these contrasting timescales and carbon isotope trends, boron-based proxy records indicate a similar surface ocean carbonate system response. In both cases, elevated LIP derived carbon dioxide emissions led to oceanic absorption of the carbon released causing a decline of surface ocean pH and an increase in dissolved inorganic carbon. We conclude that, although similar underlying carbon-cycle processes are at play during both events, their specific behavior is somewhat different as the magnitude, carbon emissions rate (slow vs. fast), and background climate state (icehouse vs. greenhouse) conspire to cause distinct carbon isotope expressions in the sedimentary record and variable climatic responses to each LIP emplacement.