Antarctic teleost immunoglobulins: More extreme, more interesting

Coscia, Maria Rosaria; Varriale, Sonia; Giacomelli, Stefano; Oreste, Umberto

doi:10.1016/j.fsi.2010.10.018

Cited by 24 publications

(15 citation statements)

References 49 publications

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“…The Antarctic marine environment is rich in microorganisms and parasitic organisms, especially in vertebrates. Parasitism is a very frequent occurrence in Antarctic teleosts, especially by nematodes [82]. The fish spleen is an organ primarily involved in immune defenses, being the site of leukocyte production [83], and ROS can form in large quantities during inflammatory processes and phagocytic cell activity.…”

Section: Discussionmentioning

confidence: 99%

Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature

et al. 2020

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In the present study, we describe the purification and molecular characterization of Cu,Zn superoxide dismutase (SOD) from Chionodraco hamatus, an Antarctic teleost widely distributed in many areas of the Ross Sea that plays a pivotal role in the Antarctic food chain. The primary sequence was obtained using biochemical and molecular biology approaches and compared with Cu,Zn SODs from other organisms. Multiple sequence alignment using the amino acid sequence revealed that Cu,Zn SOD showed considerable sequence similarity with its orthologues from various vertebrate species, but also some specific substitutions directly linked to cold adaptation. Phylogenetic analyses presented the monophyletic status of Antartic Teleostei among the Perciformes, confirming the erratic differentiation of these proteins and concurring with the theory of the “unclock-like” behavior of Cu,Zn SOD evolution. Expression of C. hamatus Cu,Zn SOD at both the mRNA and protein levels were analyzed in various tissues, highlighting the regulation of gene expression related to environmental stress conditions and also animal physiology. The data presented are the first on the antioxidant enzymes of a fish belonging to the Channichthyidae family and represent an important starting point in understanding the antioxidant systems of these organisms that are subject to constant risk of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature

et al. 2020

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“…It does not seem that Antarctic skate heavy chains are particularly rich in putative N-glycosylation sites, so are those from Antarctic teleosts (Coscia et al, 2010b). The number of putative N-glycosylation sites was almost similar in both Antarctic and temperate skates, despite minor differences in the position.…”

Section: Discussionmentioning

confidence: 87%

Immunoglobulin from Antarctic fish species of Rajidae family

et al. 2012

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“…These include, among the others, anti-freeze glycoproteins, high mitochondrial density, cold-efficient microtubule assembly and physiological compensations for the lack of the swim bladder 25,26 . Moreover, Antarctic fish show peculiar aspects linked to their immune system, as evidenced by the unique features of their immunoglobulin genes compared to non-Antarctic species, such as the presence of a long hinge peptide 27,28 .…”

Section: Introductionmentioning

confidence: 99%

Molecular and Structural Characterization of MHC Class II β Genes Reveals High Diversity in the Cold-Adapted Icefish Chionodraco hamatus

Gerdol

Lucente

Buonocore

et al. 2019

Sci Rep

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This study reports the presence of two distinct MHC class II β genes in the Antarctic icefish Chionodraco hamatus , belonging to the classical (ChhaDAB) and nonclassical (ChhaDBB) evolutionary lineages. By the application of targeted sequencing approach, a remarkable molecular diversity in the exon 2 sequence of the highly expressed gene ChhaDAB has been observed, resulting in an estimate of 92 different variants translated in 87 different peptides from 54 analysed icefish individuals. A highly conservative estimate, based on a 95% sequence identity threshold clustering, translate this variability in 41 different peptide clusters belonging to four different clades and showing the signature of different kinds of selection. In stark contrast, the poorly expressed ChhaDBB gene displayed a very low level of molecular diversity within exon 2, in agreement with expectations for a nonclassical MHC class II β gene.

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Antarctic teleost immunoglobulins: More extreme, more interesting

Cited by 24 publications

References 49 publications

Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature

Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature

Immunoglobulin from Antarctic fish species of Rajidae family

Molecular and Structural Characterization of MHC Class II β Genes Reveals High Diversity in the Cold-Adapted Icefish Chionodraco hamatus

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