Ante mortem diagnosis of tuberculosis in cattle: A review of the tuberculin tests, γ-interferon assay and other ancillary diagnostic techniques

Rúa-Doménech, Ricardo de la; Goodchild, Tony; Vordermeier, H. M.; Hewinson, R. Glyn; Christiansen, K. H.; Clifton-Hadley, R. S.

doi:10.1016/j.rvsc.2005.11.005

Cited by 615 publications

(812 citation statements)

References 92 publications

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“…This might suggest that culling has more influence on OTF‐W incidents than those without postmortem evidence of infection, suggesting that there is a stronger association between badgers and the occurrence of OTF‐W incidents compared with all TB incidents. The probability of M. bovis infection in a herd will be higher for OTF‐W incidents than for TB incidents that have not been confirmed by postmortem evidence of infection which could possibly increase the power to detect effects (De la Rua‐Domenech et al., 2006). …”

Section: Discussionmentioning

confidence: 99%

Assessing the effects of the first 2 years of industry‐led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013–2015

Brunton

Donnelly

O’Connor

et al. 2017

Ecology and Evolution

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Culling badgers to control the transmission of bovine tuberculosis (TB) between this wildlife reservoir and cattle has been widely debated. Industry‐led culling began in Somerset and Gloucestershire between August and November 2013 to reduce local badger populations. Industry‐led culling is not designed to be a randomized and controlled trial of the impact of culling on cattle incidence. Nevertheless, it is important to monitor the effects of the culling and, taking the study limitations into account, perform a cautious evaluation of the impacts. A standardized method for selecting areas matched to culling areas in factors found to affect cattle TB risk has been developed to evaluate the impact of badger culling on cattle TB incidence. The association between cattle TB incidence and badger culling in the first 2 years has been assessed. Descriptive analyses without controlling for confounding showed no association between culling and TB incidence for Somerset, or for either of the buffer areas for the first 2 years since culling began. A weak association was observed in Gloucestershire for Year 1 only. Multivariable analysis adjusting for confounding factors showed that reductions in TB incidence were associated with culling in the first 2 years in both the Somerset and Gloucestershire intervention areas when compared to areas with no culling (incidence rate ratio (IRR): 0.79, 95% CI: 0.72–0.87, p < .001 and IRR: 0.42, 95% CI: 0.34–0.51, p < .001, respectively). An increase in incidence was associated with culling in the 2‐km buffer surrounding the Somerset intervention area (IRR: 1.38, 95% CI: 1.09–1.75, p = .008), but not in Gloucestershire (IRR: 0.91, 95% CI: 0.77–1.07, p = .243). As only 2 intervention areas with 2 years of data are available for analysis, and the biological cause–effect relationship behind the statistical associations is difficult to determine, it would be unwise to use these findings to develop generalizable inferences about the effectiveness of the policy at present.

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Section: Discussionmentioning

confidence: 99%

Assessing the effects of the first 2 years of industry‐led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013–2015

Brunton

Donnelly

O’Connor

et al. 2017

Ecology and Evolution

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“…Several methods have been to this end both the direct detection of the etiologic agent in biological material, as in the indirect detection through the identification of a host immune response to the etiologic agent. (de la Rua-Domenech et al, 2006). Among which we can mention the tuberculin test, culture, post mortem examination, ELISA, interferon-gama and molecular assays (Schiller et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of bovine tuberculosis: review of main techniques

2015

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Bovine tuberculosis (BTB) remains an important economic and zoonotic problem in Latin America. Traditionally, the fight against BTB is initiated by the implementation of routine diagnostic tests for certification of free properties. The diagnosis of BTB can be made by direct and indirect methods, in which we can mention clinical, post mortem, histopathological, immunological, bacteriological and molecular methods. The renewal of scientific interest in tuberculosis in recent year has led to develop and improve methods of diagnosis, prevention, control and eradication of BTB. The aim of this review is to present and discuss different diagnosis methods of BTB.Keywords: tuberculosis bovine, diagnosis, Mycobacterium bovis, new techniques. Diagnóstico de tuberculose bovina: revisão das principais técnicas ResumoA tuberculose bovina (BTB) continua sendo um importante problema econômico na América Latina, com potenciais consequências zoonóticas. Tradicionalmente, a luta contra a tuberculose bovina tem sido iniciada pela execução de testes de diagnóstico de rotina para a certificação de propriedades livres da doença. O diagnóstico de BTB pode ser feito através de métodos diretos e indiretos, nos quais podemos citar os métodos clínicos, post mortem, histopatológicos, imunológicos, bacteriológicos e moleculares. A renovação do interesse científico em tuberculose nos últimos anos tem levado à necessidade de desenvolver e melhorar os métodos de diagnóstico, prevenção, controle e erradicação da BTB. O objetivo deste artigo é analisar e discutir sobre os diferentes métodos de diagnóstico de BTB.Palavras-chave: tuberculose bovina, diagnóstico, Mycobacterium bovis, novas técnicas.

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“…The culture-negative results could be because of early stages of infection, state of latency or nonspecific sensitization in the tuberculin skin test due to infection with bacteria from non-mycobacterial origin (40).…”

Section: Discussionmentioning

confidence: 99%

Bovine Tuberculosis in the Republic of Macedonia: Postmortem, Microbiological and Molecular Study in Slaughtered Reactor Cattle

Cvetkovikj

Mrenoshki

Krstevski

et al. 2017

Macedonian Veterinary Review

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Bovine tuberculosis is a chronic infectious disease in cattle caused mainly by Mycobacterium bovis and to a lesser extent by Mycobacterium caprae. The other members of the Mycobacterium tuberculosis complex (MTBC) can also cause the disease in domestic and wild animals and all of them have a zoonotic potential. The main purpose of the study was to determine the presence and distribution of the tuberculous lesions in reactor cattle, and to isolate and identify the causative agents of bovine tuberculosis in the Republic of Macedonia. Lymph nodes and affected organs from 188 reactor cattle slaughtered due to a positive intradermal comparative cervical tuberculin test were analyzed by detection of tuberculous lesions, followed by isolation and molecular identification of the isolated mycobacteria. The isolation was performed on selective mediaLowenstein Jensen with glycerol, Lowenstein Jensen without glycerol and Stonebrink medium supplemented with pyruvate. The molecular identification of the MTBC members was performed by analysis of the Regions of difference (RD1, RD9 and RD4) and detection of single nucleotide polymorphisms in the lepA gene for Mycobacterium caprae. Typical tuberculous lesions were detected in 62 animals (33.0%) and the lesions were most prevalent in the mediastinal lymph nodes (47.5%). The isolated mycobacteria in the MTBC were identified as Mycobacterium bovis and Mycobacterium caprae and were found in both animals with visible lesions (82.2%) and animals without visible lesions (27.7%). The slaughterhouse postmortem examinations and laboratory investigations should be included on regular bases in order to improve the National eradication program.

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Ante mortem diagnosis of tuberculosis in cattle: A review of the tuberculin tests, γ-interferon assay and other ancillary diagnostic techniques

Cited by 615 publications

References 92 publications

Assessing the effects of the first 2 years of industry‐led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013–2015

Assessing the effects of the first 2 years of industry‐led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013–2015

Diagnosis of bovine tuberculosis: review of main techniques

Bovine Tuberculosis in the Republic of Macedonia: Postmortem, Microbiological and Molecular Study in Slaughtered Reactor Cattle

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