Antecedent infections in<scp>Guillain‐Barré</scp>syndrome patients from south India

Dutta, Debprasad; Debnath, Monojit; Nagappa, Madhu; Das, Sumit; Wahatule, Rahul; Sinha, Sanjib; Taly, Arun B.; Ravi, Vasanthapuram

doi:10.1111/jns.12459

Cited by 14 publications

(19 citation statements)

References 62 publications

(138 reference statements)

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“…Typical anti-ganglioside antibody has not been noted in arboviral infection-associated AIDP; however, in one study, antiglycolipid antibody was present in about 30% of patients with AIDP [ 101 , 107 ]. In regions with high prevalence of multiple arboviral infections, AIDP has been being reported in arboviral co-infections [ 101 , 103 , 107 , 108 ]. Similarly, AIDP has been reported with other arboviral infections including chikungunya, West Nile, and Japanese encephalitis viruses [ 109 – 117 ].…”

Section: Spectrum Of Neurological Clinical Disorders Associated With ...mentioning

confidence: 99%

Nervous System Manifestations of Arboviral Infections

et al. 2022

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Purpose of Review Complex environmental factors and human intervention influence the spread of arthropod vectors and the cycle of transmission of arboviruses. The spectrum of clinical manifestations is diverse, ranging from serious presentations like viral hemorrhagic fever (e.g., dengue, yellow fever, rift valley fever) or shock syndromes (e.g., dengue virus) to organ-specific illness like meningoencephalitis. Recent Findings A spectrum of clinical neurologic syndromes with potential acute devastating consequences or long-term sequelae may result from some arboviral infections. Summary In this review, we describe some of the most frequent and emerging neuro-invasive arboviral infections, spectrum of neurologic disorders including encephalitis, meningitis, myelitis or poliomyelitis, acute demyelinating encephalomyelitis, Guillain-Barré syndrome, and ocular syndromes.

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Section: Spectrum Of Neurological Clinical Disorders Associated With ...mentioning

confidence: 99%

Nervous System Manifestations of Arboviral Infections

et al. 2022

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“…Serum IgM antibodies to JE virus, dengue virus, and chikungunya virus were detected using the ELISA kits manufactured by the National Institute of Virology (NIV, Pune, India) and these findings have been recently published. [ 6 ] Besides this, in the current study, we examined seroreactivities to influenza and zika viruses in the patients with GBS ( n = 150) and control subjects ( n = 150). For the detection of the influenza virus, throat/nasal swabs samples were collected from the study participants.…”

Section: S Ubjects and M Ethodsmentioning

confidence: 99%

“…The data pertaining to the antecedent infections were taken from our recently published article. [ 6 ] Zika virus RNA was detected neither among patients nor in healthy controls. Two patients and none of the healthy controls tested positive for influenza virus RNA.…”

Section: R Esultsmentioning

confidence: 99%

“…[ 3 4 5 ] Contrary to the earlier studies, in our recent study, the Chikungunya virus was the most common infectious trigger of GBS, followed by C. jejuni infection. [ 6 ] It is noteworthy that not all individuals infected with these pathogens develop GBS. For example, only 1 in 1,000 individuals with C. jejuni infection develops GBS.…”

Section: Introductionmentioning

confidence: 99%

“…[ 18 19 ] We have reported the association between JE, dengue, and chikungunya virus infections and the risk of GBS in the Indian population. [ 6 ] However, the impact of such preceding arboviral infections on the ganglioside- and GSC-antibody profile is not known. To address these knowledge gaps, this study was aimed at exploring the association between six infections and antibodies against gangliosides and GSCs in patients with GBS.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barré Syndrome

Nagappa¹,

Dutta²,

Debnath³

et al. 2022

Annals of Indian Academy of Neurology

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Background and Aims: Guillain-Barré Syndrome (GBS), an immune-mediated neuropathy, is characterized by antibodies against gangliosides/ganglioside complexes (GSCs) of peripheral nerves. Antecedent infections have been reported to induce antibodies that cross-react with the host gangliosides and thereby have a pivotal role in conferring an increased risk for developing GBS. Data pertaining to the impact of various antecedent infections, particularly those prevalent in tropical countries like India on the ganglioside/GSC antibodies is sparse. We aimed at exploring the association between six antecedent infections and the profile of ganglioside/GSC antibodies in GBS. Methods: Patients with GBS (n = 150) and healthy controls (n = 50) were examined for the serum profile of antibodies against GM1, GM2, GD1a, GD1b, GT1b, and GQ1b and their GSCs by ELISA. These antibodies were correlated with immunoreactivities against Campylobacter jejuni , Japanese encephalitis (JE), dengue, influenza, zika, and chikungunya infections. Results: The frequencies of antibodies against six single gangliosides ( P < 0.001) and their GSCs ( P = 0.039) were significantly higher in patients as compared to controls. Except for GT1b-antibody which was more frequent in axonal GBS, none of the other ganglioside/GSC antibodies correlated with the electrophysiological subtypes of GBS. Antecedent JE infection was significantly associated with increased frequency of antibodies against GD1a, GD1b, GT1b, and GQ1b. Antibodies against GSCs were not influenced by the antecedent infections. Interpretation: This study for the first time shows an association between antecedent JE infection and ganglioside antibodies in GBS. This finding reinforces the determining role of antecedent infections on ganglioside antibody responses and the subsequent immunological processes in GBS.

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Article Topic: Neuropathies Due to Infections and Antimicrobial Treatments

León

García-Santibáñez

Harrison

2023

Curr Treat Options Neurol

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Purpose of eview The aim of this review is to discuss the presentation, diagnosis, and management of polyneuropathy (PN) in selected infections. Overall, most infection related PNs are an indirect consequence of immune activation rather than a direct result of peripheral nerve infection, Schwann cell infection, or toxin production, though note this review will describe infections that cause PN through all these mechanisms. Rather than dividing them by each infectious agent separately, we have grouped the infectious neuropathies according to their presenting phenotype, to serve as a guide to clinicians. Finally, toxic neuropathies related to antimicrobials are briefly summarized. Recent findings While PN from many infections is decreasing, increasing evidence links infections to variants of GBS. Incidence of neuropathies secondary to use of HIV therapy has decreased over the last few years. Summary In this manuscript, a general overview of the more common infectious causes of PN will be discussed, dividing them across clinical phenotypes: large- and small-fiber polyneuropathy, Guillain-Barré syndrome (GBS), mononeuritis multiplex, and autonomic neuropathy. Rare but important infectious causes are also discussed.

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Antecedent infections inGuillain‐Barrésyndrome patients from south India

Cited by 14 publications

References 62 publications

Nervous System Manifestations of Arboviral Infections

Nervous System Manifestations of Arboviral Infections

Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barré Syndrome

Article Topic: Neuropathies Due to Infections and Antimicrobial Treatments

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