Background: Access to skilled delivery services are crucial in reducing maternal mortality, however, the prevalence of women with assisted deliveries in our health facilities remains low with reasonable disparities between rural and urban Ghana. This study examined the utilization of skilled delivery by pregnant women and its associated factors in the Wa Municipality of Ghana.Methods: The study employed a community-based cross-sectional study. A simple random sampling was used to recruit two rural and two urban sub-districts and subsequently four communities selected from each of the respective sub-districts. Thirty-three eligible women of reproductive age (15- 49 years) who had delivered within the last one-year prior to the commencement of the study were selected from each community. A structured questionnaire was used to collate information on respondents socio-demographic, geographic and cultural factors that affect the utilization of skilled delivery services. Data was analyzed using Stata Statistical Software (version 12), frequencies and percentages were used to summarize data and associations between variables investigated with multiple regression analyses at a significance of p<0.05.Results: Out of the 527 women interviewed, 481 (91.6%) had a skilled delivery. Mothers were aged between 15 and 45 years with mean (± SD) age of 26.4 ± 9.4 years. After statistical adjustment, rural residence (AOR=2.7, 95% CI 0.8 – 8.9, p=0.036 compared with urban residence), never attended antenatal care (AOR=101, 95% CI 10.2 – 1017, p<0.001), health facility delivery (AOR=0.1, 95% CI 0.1 – 0.6, p<0.001), time taken to nearest health facility (≥31 minutes AOR=11.7, 95% CI 3.6 – 38.6, p<0.001), and no Husband’s consent (AOR=4.6, 95% CI 1.8 – 11.6, p<0.001) were significantly associated with uptake of skilled delivery services.Conclusion: The findings of this study demonstrate adequate utilization of skilled delivery services among women in the Municipality. Efforts towards improvement of skilled delivery coverage should focus on health education, especially among rural women together with the expansion of healthcare services.