The problem of infertility is the most priority and urgent in the medicine of developed countries, which is connected with a rather high frequency of infertility in the world and the lack of positive dynamics of population reproduction.The objective: evaluation of the results of a comprehensive personalized approach to the treatment of infertility in women with endometrial pathology, namely chronic endometritis, endometrial polyps, and endometrial hyperplasia.Materials and methods. In order to achieve the goal, a complex clinical-instrumental, laboratory and morphological examination of 94 patients was carried out at the clinical bases of the Department of Obstetrics, Gynecology and Perinatology of the P. L. Shupyk National Medical University of Health of Ukraine and the «Dobrobut» Medical Center during 2021–2022 years We divided all patients into the following groups: Group I (main) – patients with infertility on the background of endometrial pathology, namely chronic endometritis, endometrial polyps, and endometrial hyperplasia, whom we managed in accordance with the methodology of a personalized approach to the restoration of reproductive function developed by us (31 people ); II group (comparison) – patients with infertility on the background of endometrial pathology (chronic endometritis, endometrial polyps, and endometrial hyperplasia), whose management was in accordance with the generally accepted methodology (32 people), and III group (control) included healthy women of reproductive age (31 people).Results. During the study, the following endometrial pathology was found in groups I and II: endometrial polyps – 74.6%; endometrial hyperplasia – 25.3%; chronic endometritis – 77.7%. As a result of evaluating the expression of receptors for steroid hormones in the endometrium during the expected window of implantation, certain features were established: a shift in the expression peak of estrogen and progesterone receptors and a decrease in receptor expression compared to normal endometrium. The level of progesterone in groups I and II was significantly lower compared to the control group. During dopplerometry of the uterine arteries, hemodynamic disturbances were detected in patients of the I and II groups. According to the microscopic studies in the I and II groups of patients, we noted a significant decrease or complete absence of Lactobacillus spp.Conclusions. As a result of the application of an improved personalized approach to the management of women with infertility on the background of endometrial pathology, a two-fold increase in the frequency of pregnancy was achieved compared to patients who were managed according to the generally accepted methodology, which gives the right to recommend such an approach for wide use in practical medicine.