Antenatal depression and the impact on infant cognitive, language and motor development at six and twelve months postpartum

O’Leary, Niamh; Jairaj, Chaitra; Molloy, Eleanor J.; McAuliffe, Fionnuala M.; Nixon, Elizabeth; O’Keane, Veronica

doi:10.1016/j.earlhumdev.2019.05.021

Cited by 39 publications

(30 citation statements)

References 42 publications

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“…It is possible that the relatively mild levels of maternal depression or anxiety symptoms in the current low‐risk sample could have limited our ability to detect a significant association. However, it is worth mentioning that null findings have also been reported in clinical (O'Leary et al, 2019; Osborne et al, 2018) and high‐risk samples (Bandoli et al, 2016). Additionally, we cannot rule out that the exclusion of pregnant women with chronic medical problems or obstetric complications, resulting in a highly selected sample, might have biased the observed associations.…”

Section: Discussionmentioning

confidence: 98%

Neuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development

Nazzari

Fearon

Rice

et al. 2020

Developmental Psychobiology

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Antenatal exposure to maternal stress is a factor that may impact on offspring cognitive development. While some evidence exists of an association between maternal antenatal depressive or anxiety symptoms and infants' cognitive outcomes, less is known about the role of biological indices of maternal antenatal stress in relation to infant cognitive development. The current study investigated the association between maternal depressive and anxiety symptoms, stress and inflammatory markers during pregnancy and infant's cognitive development in a sample of 104 healthy pregnant women (mean gestational age = 34.76; SD = 1.12) and their 12-week-old infants (mean postnatal weeks = 11.96; SD = 1.85). Maternal depressive and anxiety symptoms were evaluated during pregnancy, alongside measurements of serum Interleukin-6 (IL-6), C-Reactive Protein (CRP), salivary cortisol, and alpha amylase (sAA) concentrations. Infant cognitive development, maternal caregiving and concurrent anxiety or depressive symptoms were assessed 12 weeks after delivery. Hierarchical linear regressions indicated that higher maternal diurnal cortisol and CRP levels were independently associated with lower infant cognitive development scores, while adjusting for infant gender and gestational age, maternal IQ, caregiving, depressive, or anxiety symptoms. Though correlational, findings seem suggestive of a role for variation in maternal biological stress signals during pregnancy in influencing infants' early cognitive development.

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Section: Discussionmentioning

confidence: 98%

Neuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development

Nazzari

Fearon

Rice

et al. 2020

Developmental Psychobiology

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“…Our findings of a possible association between maternal antenatal depressive symptoms and poorer receptive language domain scores on BSID-III in children at 30 months are in agreement with several earlier studies. Studies done in the US, Ethiopia and Ireland also noted an association between antenatal depression and poorer cognitive performance of children, but these effects were largely attenuated when adjusted for various socio demographic characteristics (4,9,31). In the present study, we did not do a longitudinal assessment of maternal post natal depressive symptoms which could have impacted child cognitive functions.…”

Section: Discussionmentioning

confidence: 65%

Antenatal Depressive Symptoms and Neurodevelopment Outcomes in Children at 30 Months. A Study From South India

et al. 2020

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“…This is of special clinical and public health importance, as impaired parental mental well-being during pregnancy is significantly associated with perinatal as well as long-term adversity. Numerous studies evidenced that maternal perinatal mood disorders may lead to such detrimental consequences as obstetric complications, postpartum mental health disorders, disturbances in mother-infant interactions and caregiving, alternations in child development and child developmental outcomes [9,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Antenatal depression and anxiety in primiparous Polish mothers and fathers

Kiepura

Kmita

2020

Ginekol Pol

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Objectives: Mood disturbances are the most prevalent mental health problems in expectant parents. The knowledge about the factors which increase the risk of perinatal depression is insufficient, especially in fathers. The aims of the present study were to estimate the prevalence and to compare mean levels of antenatal depression and anxiety as well as to examine the relationship between the risk for depression and anxiety in primiparous Polish parents.Material and methods: 250 parental couples participating in antenatal classes took part in the study. Depression and anxiety were measured with the Edinburgh Postnatal Depression Scale (EPDS) and the State-Trait Anxiety Inventory (STAI), respectively. Paired t-test with bootstrapping was applied to compare parental EPDS, as well as STAI raw scores. Pearson correlation coefficients were calculated for depression and anxiety scores for women and men separately. The factors predictive for the increased risk of depression were investigated with the use of a multivariate logistic regression analysis.Results: 10% of women and 4% of men were at risk of depression. High level of state anxiety was found in 7.7% of expectant mothers and 10% of fathers, whereas elevated state anxiety was found in 19% of both parents. EPDS scores correlated moderately with anxiety. The risk of depression was increased by state anxiety in the case of mothers and by trait anxiety in the case of fathers. Conclusions:High level of anxiety increases the risk of antenatal depression. Both parents should be screened for depression and anxiety in the prenatal period.

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Antenatal depression and the impact on infant cognitive, language and motor development at six and twelve months postpartum

Cited by 39 publications

References 42 publications

Neuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development

Neuroendocrine and immune markers of maternal stress during pregnancy and infant cognitive development

Antenatal Depressive Symptoms and Neurodevelopment Outcomes in Children at 30 Months. A Study From South India

Antenatal depression and anxiety in primiparous Polish mothers and fathers

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