Antenatal Deworming and Materno-Perinatal Outcomes in Calabar, Nigeria

Akpan, Ubong; Asibong, Udeme; Okpara, Henry Chima; Monjok, Emmanuel; Etuk, Saturday

doi:10.3889/oamjms.2018.143

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…Despite a few inconsistencies in some studies regarding the antenatal effect of deworming [ 6 ], WHO recommends preventive chemotherapy using single-dose albendazole (400 mg) or mebendazole (500 mg) in pregnant women in areas where the prevalence of anaemia in pregnancy is 40% or higher and the baseline prevalence of hookworm and/or T, trichiura infection is 20% or higher [ 7 ]. In a randomised controlled trial to compare the pregnancy outcomes in Nigeria among those who received 500 mg mebendazole and those who did not, the prevalence of anaemia at 37 weeks gestation and above in the treatment arm was significantly lower than in the placebo group (12.6% vs 29.9%, p < 0.001) [ 8 ]. Similar findings have been reported elsewhere [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the use of deworming drugs during pregnancy in Tanzania; an analysis from the 2015–16 Tanzanian HIV and malaria indicators survey

Bankanie

Moshi

2022

BMC Pregnancy Childbirth

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Background The use of deworming drugs is one of the important antenatal strategies in preventing anaemia in pregnancy. Little is known about the factors associated with the use of deworming drugs, which accounts for the aim of this study. Method The study used data from the 2015–16 Tanzania HIV Demographic and Health Survey and Malaria Indicators Survey (2015–16 TDHS-MIS). A total of 6924 women of active reproductive age from 15 to 49 were included in the analysis. Both univariate and multiple logistic regression analyses were used. Results The majority of interviewed women 3864(60.1%) took deworming drugs. In a weighed multiple logistic regression, women residing in urban areas reported greater use of deworming drugs than women residing in rural areas [AOR = 1.73, p = 0.01, 95% CI (1.26–2.38)]. In the four areas of residence, compared to women residing in mainland rural areas, women residing in mainland urban areas and Pemba islands reported greater use of deworming drugs [mainland urban (AOR = 2.56 p < 0.001,95% CI(1.78–3.75), and Pemba Island (AOR = 1.18, p < 0.001, 95% CI(1.17–1.20)]. However, women residing in Zanzibar Island (Unguja) were less likely to use deworming drugs compared to women in mainland rural women (AOR = 0.5, p < 0.001, 95% CI (0.45–0.55). Similarly, compared to women under 20 years of age, women between 20 to 34 years reported significantly greater use of deworming drugs [20 to 34 years (AOR = 1.30, p = 0.03, 95% CI(1.02–1.65). Likewise, greater use of deworming drugs was reported in women with a higher level of education compared to no education [higher education level (AOR = 3.25, p = 0.01,95% CI(1.94–7.92)], rich women compared to poor [rich (AOR = 1.43, p = 0.003, 95% CI (1.13–1.80)] and in women who initiated antenatal care on their first trimester of pregnancy compared to those who initiated later [AOR = 1.37, p < 0.001, 95% CI (1.17–1.61)]. Conclusion Women who were more likely to use the deworming drugs were those residing in urban compared to rural areas, aged between 20 and 34 years, those with a higher level of formal education, wealthier, and women who book the antenatal clinic (ANC) within their first trimester of pregnancy. Considering the outcomes of anaemia in pregnancy, a well-directed effort is needed to improve the use of deworming drugs.

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Section: Introductionmentioning

confidence: 99%

Factors associated with the use of deworming drugs during pregnancy in Tanzania; an analysis from the 2015–16 Tanzanian HIV and malaria indicators survey

Bankanie

Moshi

2022

BMC Pregnancy Childbirth

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“…In a developing country study [ 37 ], prenatal deworming was associated with a significant reduction in the risk of low birth weight in countries with a low prevalence of soil-transmitted helminths and a minor reduction in countries with a high prevalence. Prenatal deworming reduced the risk of low birth weight in infants weighing less than 1.5 kg in Peru [ 42 ] and Sri Lanka [ 43 ], but not in infants weighing less than 2.5 kg [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Iron supplementation and deworming during pregnancy reduces the risk of anemia and stunting in infants less than 2 years of age: a study from Sub-Saharan Africa

Traore

Kou

et al. 2023

BMC Pregnancy Childbirth

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Background In sub-Saharan Africa, infant anemia, stunting and low birth weight remains major public health problems. It is unclear whether prenatal iron supplementation and/or deworming can reduce the risk of infant stunting, anemia and low birth weight. The aim of this study was to investigate the relationship between iron supplementation and/or deworming and stunting, anemia, and low birth weight in infants under two years of age in sub-Saharan Africa. Methods Our studies examined pooled data from Demographic and Health Surveys (DHS) in twenty-three African countries collected between 2014 and 2020. childhood anemia and stunting in infants under the age of two were the primary outcomes. Iron supplementation and deworming during prenatal visits were the main exposure variables. A multivariate logistic regression model was used to investigate these relationships. Results The prevalence of stunting was 29.9%, severe stunting was 10.6%, childhood anemia was 74.3%, childhood severe anemia was 3.2%, and low birth weight was 16.4%, respectively. The use of prenatal iron supplementation alone was associated with a significant reduction of childhood anemia [aOR (95% CI) = 0.9 (0.8–1.0)]. Prenatal deworming alone was associated with a significantly reduced risk of stunting [aOR (95% CI) = 0.7 (0.8–1.0)], childhood anemia [aOR (95% CI) = 0.7 (0.8–0.9)], and low birth weight [aOR (95% CI) = 0.7 (0.8–1.0)]. Prenatal iron supplementation plus deworming or iron supplementation (with or without deworming) were not associated with childhood anemia, infant stunting and low birth weight. Conclusions In Sub-Saharan Africa, prenatal deworming alone has the potential to improve infants’ outcomes. Childhood anemia was improved with prenatal iron supplementation alone. Our recent findings indicate the necessity for prospective studies on the association between prenatal iron supplementation plus deworming and childhood anemia, stunting and low birth weight.

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“…The FDA classified mebendazole as a category C drug, which states either studies in animals have shown adverse outcomes on the fetus, and there are no available verified studies in women. In recent studies, reports about firsttrimester exposure to mebendazole are limited; however, researchers have not observed an increased incidence of congenital defects, while used during the second or third trimester (Gyorkos and St-Denis., 2019;Akpan et al, 2018). Drugs should only be an option if the likely advantage justifies the possible risk to the fetus.…”

Section: Adverse Effectmentioning

confidence: 99%

Application of spectrophotometric methods for estimation of Mebendazole in tablet formulation

Ahirwar¹,

Vinode²

2022

Adv Pharm J

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The quantitative analysis of the active constituents is reported by various spectroscopic methods in any substance or product for developing a pharmaceutical dosage form. Any changes in the quality or purity of the drug adversely affect the therapeutics value of component. Therefore, there is need of developing the better and reliable method for the estimation of drug in pharmaceutical dosage form. Mebendazole is a broad spectrum anthelmintic drug that is widely used in the treatment of helminthic of infections. Application of simple accurate and precise UV visible spectrophotometric method has been already developed and validated for the determination of Mebendazole in tablet formulation. The solvent used for development of such method are water and chaloroform. The reported method is validated as per ICH guidelines such as linearity, accuracy, precision the limit of detection, the limit of quantification and robustness. The reported results demonstrated that researchers tried to develop simple accurate rapid and validated UV spectroscopic method for the estimation of Mebendazole in tablet formulation as per ICH guidelines.

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Antenatal Deworming and Materno-Perinatal Outcomes in Calabar, Nigeria

Cited by 7 publications

References 22 publications

Factors associated with the use of deworming drugs during pregnancy in Tanzania; an analysis from the 2015–16 Tanzanian HIV and malaria indicators survey

Factors associated with the use of deworming drugs during pregnancy in Tanzania; an analysis from the 2015–16 Tanzanian HIV and malaria indicators survey

Iron supplementation and deworming during pregnancy reduces the risk of anemia and stunting in infants less than 2 years of age: a study from Sub-Saharan Africa

Application of spectrophotometric methods for estimation of Mebendazole in tablet formulation

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