Antenatal Diagnosis of Dizygotic, Monochorionic Twins Following IVF/ICSI

Korsun, P.; Bals‐Pratsch, M.; Ortmann, O.; Markus, Susan; Germer, U.

doi:10.1055/s-0042-101024

Cited by 4 publications

(4 citation statements)

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“…Several studies have reported chimerism in tissues other than the blood (Fumoto et al, 2014;Rodriguez-Buritica et al, 2015;Korsun et al, 2016;Uysal et al, 2018). However, in this case, chimerism was only observed in blood cells and not in other tissues.…”

Section: Discussionmentioning

confidence: 60%

“…An increasing number of MCDZ twins has been reported, and at least 80% of the reported cases were conceived by ART (Williams et al, 2004;Aoki et al, 2006;Ekelund et al, 2008;Parva et al, 2009;Assaf et al, 2010;Choi et al, 2013;Smeets et al, 2013;Lee et al, 2014a;Lee et al, 2014b;Fumoto et al, 2014;Korsun et al, 2016;Mayeur Le Bras et al, 2016). This indicates that when monochorionic twins, which originated from the transfer of two embryos, are diagnosed by ultrasound, we should consider two possibilities: the first possibility is that one embryo died and the other embryo developed to be monochorionic monozygotic (MCMZ), or alternatively, both embryos survive, share the placenta, and develop into MCDZ.…”

Section: Discussionmentioning

confidence: 99%

“…In theory, the cell exchange between two fetuses only occurs in blood cells. However, chimerism in other tissues has been reported in several studies (Fumoto et al, 2014;Rodriguez-Buritica et al, 2015;Korsun et al, 2016;Uysal et al, 2018), and the early-stage fusion of dizygotic embryos was speculated to be the reason for occurrence. The presence of tissue chimerism might lead to serious clinical consequences in MCDZ twins, especially in opposite-sex MCDZ twins.…”

Section: Introductionmentioning

confidence: 99%

“…Monochorionic twins are generally considered to be monozygotic. However, monochorionic dizygotic (MCDZ) twins, an extremely rare occurrence, have been reported due to rapidly improving cytogenetic and DNA sequencing techniques (Nylander and Osunkoya, 1970;Lee et al, 2014a;Rodriguez-Buritica et al, 2015;Korsun et al, 2016;Uysal et al, 2018;Gabbett et al, 2019). MCDZ twins share the same placenta, which leads to cell exchange between embryos with different genotypes via vascular anastomoses, resulting in blood chimerism.…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Identification of Germline Chimerism in Monochorionic Dizygotic Twins

Chen

et al. 2021

Front. Genet.

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Monochorionic twins are generally considered to be monozygotic, as monochorionic dizygotic (MCDZ) twins are extremely rare in natural pregnancies. Several studies have reported this rare occurrence, and most of these pregnancies have been conceived by assisted reproductive technology (ART). These reports mostly focused on MCDZ twin pregnancies and the childhood development of the twins; a follow-up into adulthood and the effect on their reproduction has not been reported. In this case study, we report a case of chimerism in opposite-sex MCDZ twins who were naturally conceived and have reached reproductive maturity. We collected oral mucosal, endometrial, and germ cells from the twins and evaluated their chimerism using single-nucleotide polymorphism (SNP) array and droplet digital PCR (ddPCR). The SNP array showed that they had 4,049 non-allele shared loci, and they inherited nearly 50% informative SNP loci from each parent, confirming that they are dizygotic twins. We found that the female twin had a 46, XX (2)/46, XY (78) karyotype in her peripheral blood. The SNP array confirmed that the female twin and male twin had the same blood haplotype. The ddPCR result showed 92.84 (± 1.80%) chimerism in her blood. In case of chimerism in her germline, the female twin chose preimplantation genetic testing for aneuploidy for her blastocysts. Fortunately, the patient only had blood chimerism. A healthy boy was born at 39 weeks of gestation.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Case Report: Identification of Germline Chimerism in Monochorionic Dizygotic Twins

Chen

et al. 2021

Front. Genet.

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Fetal sex discordance in a monochorionic twin pregnancy following intracytoplasmic sperm injection: A case report of chimerism and review of the literature

Uysal

Gülümser

Çelik

et al. 2017

J of Obstet and Gynaecol

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A 39-year-old woman who became pregnant with twins after an intracytoplasmic sperm injection was referred at the ninth gestational week to determine chorionicity. Ultrasonographic examination showed a monochorionic diamniotic twin pregnancy. First trimester nuchal translucency measurements of the fetuses were 1.6 and 2.7 mm. A non-invasive prenatal test was performed and revealed low risk. One fetus appeared to be female and the other male at the 14th gestational week. Second trimester anatomic scanning results were otherwise normal for both fetuses. The newborns delivered at term appeared to be normal female and male babies phenotypically. At the fourth month, buccal cell analysis showed chimeric karyotypes, 46,XX[98]/46,XY[2] and 46,XY[98]/46,XX[2] in the female and male infant, respectively. The recognition of sex discordance despite monochorionicity may be a clue for the diagnosis of such rare cases of chimerism in dizygotic twins, most of which occur in pregnancies obtained by assisted reproductive technology.

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