Antenatal Exposure to Selective Serotonin Reuptake Inhibitors and Duration of Gestation

Andrade, Chittaranjan

doi:10.4088/jcp.13f08617

Cited by 3 publications

(2 citation statements)

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“…A single injection of bromodeoxyuridine at E12-E15 produces widespread changes in cerebral structure and function (Kolb et al, 2012). Prescription drug exposure during pregnancy in humans and other animals is also well known to affect anatomical and functional brain outcomes in offspring (Andrade, 2013a,b; Ungerer et al, 2013; Liew et al, 2014). The unique finding of the current study is the demonstration that sensory-motor experience of a dam during her pregnancy can influence the brain development and function in her offspring throughout the lifespan.…”

Section: Discussionmentioning

confidence: 99%

Prenatal enrichment and recovery from perinatal cortical damage: effects of maternal complex housing

Gibb

Gonzalez

Kolb

2014

Front. Behav. Neurosci.

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Birth is a particularly vulnerable time for acquiring brain injury. Unfortunately, very few treatments are available for those affected. Here we explore the effectiveness of prenatal intervention in an animal model of early brain damage. We used a complex housing paradigm as a form of prenatal enrichment. Six nulliparous dams and one male rat were placed in complex housing (condomom group) for 12 h per day until the dams' delivered their pups. At parturition the dams were left in their home (standard) cages with their pups. Four dams were housed in standard cages (cagemom group) throughout pregnancy and with their pups until weaning. At postnatal day 3 (P3) infants of both groups received frontal cortex removals or sham surgery. Behavioral testing began on P60 and included the Morris water task and a skilled reaching task. Brains were processed for Golgi analyses. Complex housing of the mother had a significant effect on the behavior of their pups. Control animals from the condomom group outperformed those of the cagemom group in the water task. Condomom animals with lesions performed better than their cagemom cohorts in both the water task and in skilled reaching. Condomom animals showed an increase in cortical thickness at anterior planes and thalamic area at both anterior and posterior regions. Golgi analyses revealed an increase in spine density. These results suggest that prenatal enrichment alters brain organization in manner that is prophylactic for perinatal brain injury. This result could have significant implications for the prenatal management of infants expected to be at risk for difficult birth.

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Section: Discussionmentioning

confidence: 99%

Prenatal enrichment and recovery from perinatal cortical damage: effects of maternal complex housing

Gibb

Gonzalez

Kolb

2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…An important limitation of this strategy is that it assumes that the date of delivery can be pinpointed. If delivery is unexpectedly early, as may occur in antidepressant-treated women, 26,27 this strategy may not be implementable, and if delivery is delayed for any reason, prolongation of a low-dose or a drugfree period may risk relapse of depressive illness, which defeats the purpose of having exposed the offspring to the drug during pregnancy. The taperand-transiently-discontinue strategy is intuitively appealing, and a register-based study by Warburton et al 28 indeed found that respiratory distress and convulsions were each less likely to occur in neonates who had not been exposed to selective serotonin reuptake inhibitors in the 2 weeks before delivery (n = 2,122) relative to those who were exposed (n = 1,605); however, this finding disappeared in a propensity-matched analysis (n = 239 per group), implying that maternal illness characteristics may also drive the clinical features of PNAS.…”

Section: Practical Notes About Dosingmentioning

confidence: 99%