Antenatal Glucocorticoid Therapy: Clinical Effects

Ballard, Philip L.

doi:10.1007/978-3-642-82483-8_5

Cited by 6 publications

(3 citation statements)

References 68 publications

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“…However, in view of the recent success ofsurfactant replacement therapies (43, 44), pulmonary indications for this treatment may decrease. If so, other benefits ofmaternal glucocorticoid treatment will have to be weighed against known and potential adverse effects (42,45,46). While clinically, skin maturation of the premature infant appears to be accelerated by maternal glucocorticoid treatment (42), glucocorticoids did not accelerate skin maturation in the fetal rabbit (47).…”

Section: Resultsmentioning

confidence: 99%

Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.

Aszterbaum¹,

Feingold²,

Menon³

et al. 1993

J. Clin. Invest.

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The cutaneous permeability barrier to systemic water loss is mediated by hydrophobic lipids forming membrane bilayers within the intercellular domains of the stratum corneum (SC). The barrier emerges during day 20 of gestation in the fetal rat and is correlated with increasing SC thickness and increasing SC lipid content, the appearance ofwell-formed lamellar bodies in the epidermis, and the presence of lamellar unit structures throughout the SC. Because glucocorticoids accelerate lung lamellar body and surfactant maturation in man and experimental animals, these studies were undertaken to determine whether maternal glucocorticoid treatment accelerates maturation of the epidermal lamellar body secretory system. Maternal rats were injected with betamethasone or saline (control) on days 16-18, and pups were delivered prematurely on day 19. Whereas control pups exhibited immature barriers to transepidermal water loss (8.16±0.52 mg/cm2 per h), glucocorticoidtreated pups exhibited competent barriers (0.74±0.14 mg/cm2 per h; P < 0.001). Glucocorticoid treatment also: (a) accelerated maturation of lamellar body and SC membrane ultrastructure; (b) increased SC total lipid content twofold; and (c) increased cholesterol and polar ceramide content three-to sixfold. Thus, glucocorticoids accelerate the functional, morphological, and lipid biochemical maturation of the permeability barrier in the fetal rat. (J. Clin. Invest. 1993. 91:2703-2708.) Key words: epidermal lamellar body. stratum corneum lipids -transepidermal water loss -permeability barrier

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Section: Resultsmentioning

confidence: 99%

Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.

Aszterbaum¹,

Feingold²,

Menon³

et al. 1993

J. Clin. Invest.

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“…105,133 This has been referred to as the prenatal cortisol surge. 422 As indicated, parturition is also associated with enormous increases in circulating catecholamine concentrations, which subserve critical extrauterine transitional events. The increase in circulating cortisol concentrations is associated with a variety of physiologic responses.…”

Section: Cortisol-and Catecholamine-mediated Adaptationsmentioning

confidence: 99%

“…309,312,422 The insulin-secretory response to hyperglycemia matures in the neonatal period, and healthy term infants achieve adultlike regulation of glucose homeostasis within days of birth. This relative hypoglycemia, along with the augmented catecholamine levels largely caused by the absence of placental degradation, stimulates pancreatic glucagon secretion.…”

Section: Glucose Homeostasismentioning

confidence: 99%

Fetal and Neonatal Endocrinology

Gevers¹,

Fisher²,

Dattani³

2016

Endocrinology: Adult and Pediatric

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Predicting low apgar scores of infants weighing less than 1000 grams: The effect of corticosteroids

Gardner

Goldenberg

Gaudier

et al. 1995

Obstetrics & Gynecology

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Neonates at very low gestational ages and birth weights are more likely than larger or more mature infants to have low Apgar scores. Males, nonvertex-presenting infants, and those who are acidotic at birth also have an increased prevalence of low scores. Infants born to mothers treated with antenatal corticosteroids are less likely to have low Apgar scores. This finding indicates that antenatal corticosteroids may benefit the newborn at birth, before respiratory distress syndrome becomes apparent.

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Antenatal Glucocorticoid Therapy: Clinical Effects

Cited by 6 publications

References 68 publications

Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.

Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.

Fetal and Neonatal Endocrinology

Predicting low apgar scores of infants weighing less than 1000 grams: The effect of corticosteroids

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