Antenatal prognostic factor of fetal echogenic bowel

Ronin, Candice; Macé, Pierre; Stenard, Fabien; Loundou, Anderson; Capelle, M.; Mortier, Isabelle; Pellissier, Marie Christine; Sigaudy, Sabine; Lévy, A.; D’ercole, C.; Hoffmann, P.; Merrot, Thierry; Lopater, J.; Lagausie, Pascal de; Philip, Nicole; Bretelle, Florence

doi:10.1016/j.ejogrb.2017.01.060

Cited by 22 publications

(22 citation statements)

References 18 publications

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“…In a study, 7% of fetuses with down syndrome were associated with isolated HEB. Despite this high rate, HEB is not a specific marker for trisomy 21 but can be considered as a soft marker according to the literature (9,10,19). In a meta-analysis performed in North America, 230 cases were evaluated and in 60% of all cases, there was not the additional anomaly in the postnatal follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis performed in North America, 230 cases were evaluated and in 60% of all cases, there was not the additional anomaly in the postnatal follow-up. Karyotype abnormalities, intrauterine growth, and perinatal mortality rates were high in the diseased group (7)(8)(9)(10)13). Sex chromosomal abnormalities such as turner syndrome were determined among the aneuploidies, mostly trisomy 21.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperechogenic bowel is observed between 0.6% and 1.4% in the second trimester ultrasonography (8)(9)(10). It is predicted that perinatal complications (intrauterine growth restriction, intraamniotic hemorrhage, perinatal death, karyotype anomalies, cytomegalovirus, parvovirus, toxoplasmosis, fetal metabolic diseases, small bowel obstruction, bowel agenesis, observer error, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…can be seen in 4-20% of pregnancies (11,12). In the second trimester, in 60% of fetuses with HEB, no anomaly is seen in the postnatal period, although 40% karyotype anomaly, intrauterine growth restriction (IUGR) or perinatal death can be seen (7,8,10,13). HEB should be evaluated routinely on second trimester sonography as it is accompanied by anomalies leading to perinatal morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study

Şal

Cömert

Ekici

et al. 2020

Gynecol Obstet Reprod Med

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Objective: The aim of this study is to evaluate perinatal outcome of fetal echogenic bowel. Study Design: In this retrospective cohort study, fetuses with echogenic bowel diagnosed and followed in our center between 2013-2017 were included. Fetuses and infants were evaluated in terms of antenatal comorbidities and postnatal persistent diseases. Infants were followed-up to June 2018 from time of diagnosis. Demographic questionnaire and face to face interview were used to obtain data including immune system diseases and respiratory system pathologies in infants. Results: A total of 100 fetuses with echogenic bowel were included in the study. Fetal aneuploidy was detected in 7 (7%) cases. Trisomy 21 was the most common aneuploidy and identified in 4 (4%) cases. Other chromosomal disorders were tetrasomy 12p (1%), 69XXX (1%) and 46 XX, t (2,22) (9q9) (1%). A fetal echogenic bowel was associated with major congenital malformations in 25 (%25) cases. Cardiac abnormality was the most prevalent (%7). First and second trimester vaginal bleeding history was found in 5 pregnant women. In 3 case with isolated echogenic bowel (no congenital malformation and aneuploidy), lactose intolerance, celiac disease, and non-obstructive hydrocephalus were diagnosed in early childhood. Conclusion: Isolated fetal echogenic bowel which can be considered as a soft marker for aneuploidy may be associated with lactose intolerance and celiac disease. Further clinical studies are warranted to evaluate this relationship.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study

Şal

Cömert

Ekici

et al. 2020

Gynecol Obstet Reprod Med

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“…Buiter et al 7 reported that all fetuses with isolated FEB had uneventful pregnancies with no pathological abnormalities postpartum concluding that isolated FEB is a benign sonographic finding which carries a favourable prognosis. Furthermore, Ronin et al 24 reported that the grade of FEB has no association with neonatal outcome and should no longer be employed. Moreover, isolated FEB and sonographic resolution of FEB are the strongest prognostic factors with a 6.6-fold and 8.1-fold increase in the chance of an uneventful neonatal outcome, respectively.…”

Section: Commentarymentioning

confidence: 99%

Should postnatal ultrasound be performed when isolated echogenic bowel has been reported on the antenatal ultrasound?

Paddock¹,

Beattie

Froste

et al. 2019

Arch Dis Child

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Outcome of fetal echogenic bowel: A systematic review and meta‐analysis

et al. 2021

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The main aim of this systematic review was to explore the outcome of fetuses with isolated echogenic bowel (EB) on antenatal ultrasound. Inclusion criteria were singleton pregnancies with isolated EB no associated major structural anomalies at the time of diagnosis. The outcomes observed were: chromosomal anomalies, cystic fibrosis (CF), associated structural anomalies detected only at follow-up scans and at birth, regression during pregnancy, congenital infections, intrauterine (IUD), neonatal (NND) and perinatal (PND) death. Twenty-five studies (12 971 fetuses) were included. Chromosomal anomalies occurred in 3.3% of the fetuses, mainly Trisomy 21 and aneuploidies involving the sex chromosomes. Cystic fibrosis occurred in 2.2%. Congenital infections affected 2.2%, mainly congenital Cytomegalovirus (CMV) infection. The majority of fetuses with EB experienced regression or disappearance of the EB at follow-up scans. Associated anomalies were detected at a follow-up scan in 1.8%. Associated anomalies were detected at birth and missed at ultrasound in 2.1% of cases. IUD occurred in 3.2% of cases while the corresponding figures for NND and PND were 0.4% and 3.1%. Fetuses with EB are at increased risk of adverse perinatal outcome, highlighting the need for a thorough antenatal management and postnatal follow-up. Assessment during pregnancy and after birth should be performed in order to look for signs of fetal aneuploidy, congenital infections and associated structural anomalies.

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Antenatal prognostic factor of fetal echogenic bowel

Cited by 22 publications

References 18 publications

Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study

Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study

Should postnatal ultrasound be performed when isolated echogenic bowel has been reported on the antenatal ultrasound?

Outcome of fetal echogenic bowel: A systematic review and meta‐analysis

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