Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure

Cookson, Michael W.; Ryan, Sharon; Seedorf, Gregory J.; Dodson, R. Blair; Abman, S. H.; Mandell, Erica W.

doi:10.1055/s-0038-1642033

Cited by 14 publications

(14 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a further study by Cookson et al, 24 it was found that prenatal supplementation with 1,25(OH) 2 D 3 could restore birth weight, blood vessel density, and placental weight. They also reported that vitamin D increased placental blood vessel growth by stimulating the growth of endothelial cells and increasing the expression of vascular endothelial growth factor 24 . Mandell et al 25 established a BPD rat model by prenatal intraamniotic injection of endotoxin.…”

Section: Discussionmentioning

confidence: 91%

“…Studies have reported that the histological evidence of insufficient placental vascular perfusion is closely related to the high incidence of fetal growth restriction and BPD, but the mechanism for increased susceptibility is not clear 22,23 . In a further study by Cookson et al, 24 it was found that prenatal supplementation with 1,25(OH) 2 D 3 could restore birth weight, blood vessel density, and placental weight. They also reported that vitamin D increased placental blood vessel growth by stimulating the growth of endothelial cells and increasing the expression of vascular endothelial growth factor 24 .…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

Liu

et al. 2021

Pediatric Pulmonology

View full text Add to dashboard Cite

BackgroundDespite improvements made in neonatal care, bronchopulmonary dysplasia (BPD) is still the most common respiratory disease in preterm infants. The relationship between the blood contents of vitamin D/E in premature infants and BPD is still controversial.MethodsPreterm infants were recruited as the research subjects. On the basis of the inclusion and exclusion criteria, a total of 133 eligible cases were finally included. A total of 63 preterm infants with a clear diagnosis of BPD and 5 preterm infants who died before the diagnosis of BPD were in the case group, and 65 non‐BPD preterm infants with equivalent baseline characteristics were in the control group. The BPD group included 38 cases in Grade Ⅰ, 18 cases in Grade Ⅱ, and 12 cases in Grade Ⅲ. The contents of vitamin D and E in the cord blood of different groups were detected by high‐performance liquid chromatography and enzyme‐linked immunosorbent assay. Correlation analysis adopted the Pearson correlation analytic method.ResultsThe serum vitamin D and E levels at birth were remarkably lower in the BPD group than the non‐BPD group, both of which were also correlated with the severity of BPD. The vitamin D and E contents were negatively correlated with the oxygen support duration required for premature infants with BPD.ConclusionThis study deepens our understanding of the field of BPD pathogenesis by demonstrating an association between vitamin D/E deficiency and BPD severity, suggesting that vitamin D and E might have potential clinical value in the prognosis and treatment of BPD.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 97%

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

Liu

et al. 2021

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Formalin-fixed, paraffin-embedded placental tissue sections (5 mm) were used for hemotoxylin and eosin (H&E) and CD34 (vascular endothelial marker) staining and processed for histological staining and immunohistochemistry to assess placental vascularity. The CD34-stained slides were quantified for vascularity using the Matlab Image Processing Toolbox (MathWorks, Natick, MA, USA) as previously described in Cookson et al (25). Fields of view were captured across the placenta at 320 magnification.…”

Section: Assessment Of Placental Vascularitymentioning

confidence: 99%

Pharmacological activation of peroxisome proliferator‐activated receptor γ (PPAR‐γ) protects against hypoxia‐associated fetal growth restriction

et al. 2019

View full text Add to dashboard Cite

The hypoxia of high‐altitude (HA) residence increases the risk of intrauterine growth restriction (IUGR) and preeclampsia 3‐fold, augmenting perinatal morbidity and mortality and the risk for childhood and adult disease. Currently, no effective therapies exist to prevent these vascular disorders of pregnancy. The peroxisome proliferator‐activated receptor γ (PPAR‐γ) is an important regulator of uteroplacental vascular development and function and has been implicated in the pathogenesis of IUGR and preeclampsia. Here, we used a model of HA pregnancy in mice to determine whether hypoxia‐induced fetal growth restriction reduces placental PPAR‐γ protein expression and placental vascularization and, if so, to evaluate the effectiveness of the selective PPAR‐γ agonist pioglitazone (PIO) for preventing hypoxia‐induced IUGR. Hypoxia resulted in asymmetric IUGR, placental insufficiency, and reduced placental PPAR‐γ expression; PIO prevented approximately half of the fetal growth restriction and attenuated placental insufficiency. PIO did not affect fetal growth under normoxia. Although PIO was beneficial for fetal growth, PIO treatment reduced placental vascular density of the labrynthine zone in normoxic and hypoxic (Hx) conditions, and mean vascular area was reduced in the Hx group. Our results suggest that pharmacological PPAR‐γ activation is a potential strategy for preventing IUGR in pregnancies complicated by hypoxia, although further studies are needed to identify its likely metabolic or vascular mechanisms.—Lane, S. L., Dodson, R. B., Doyle, A. S., Park, H., Rathi, H., Matarrazo, C. J., Moore, L. G., Lorca, R. A., Wolf son, G. H. Julian, C. G. Pharmacological activation of peroxisome proliferator‐activated receptor γ (PPAR‐γ) protects against hypoxia‐associated fetal growth restriction. FASEB J. 33, 8999–9007 (2019). http://www.fasebj.org

show abstract

“…More recently, direct demonstration of the importance of Vitamin D in pregnancy and BPD has been obtained from experiments in which antenatal Vitamin D supplementation was associated with improved placental vascularization and fetal growth. 78 Postnatal Vitamin D supplementation was associated with an improvement in alveolarization in rats that were exposed to intra-amniotic LPS, 79 and Vitamin D induced downregulation of TLR4 and therefore decreased downstream cytokines such as IL1ß in neonatal rats exposed to hyperoxia. 80 The effects of Vitamin D on the activation of eNOS likely contribute to the beneficial observations with Vitamin D both on the placenta and postnatal vascular and alveolar growth.…”

Section: Vitamin Dmentioning

confidence: 95%

Modulators of inflammation in Bronchopulmonary Dysplasia

Savani

2018

Seminars in Perinatology

View full text Add to dashboard Cite

Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30–50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung that results in an inflammatory response and ends in aberrant lung development with dysregulated angiogenesis and alveolarization. Significant morbidity and mortality are associated with this most common chronic lung disease of childhood. Thus, any therapies that decrease the incidence or severity of this condition would have significant impact on morbidity, mortality, human costs, and healthcare expenditure. It is clear that an inflammatory response and the elaboration of growth factors and cytokines are associated with the development of BPD. Numerous approaches to control the inflammatory process leading to the development of BPD have been attempted. This review will examine the anti-inflammatory approaches that are established or hold promise for the prevention or treatment of BPD.

show abstract

Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure

Cited by 14 publications

References 62 publications

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

The association of vitamin D and vitamin E levels at birth with bronchopulmonary dysplasia in preterm infants

Pharmacological activation of peroxisome proliferator‐activated receptor γ (PPAR‐γ) protects against hypoxia‐associated fetal growth restriction

Modulators of inflammation in Bronchopulmonary Dysplasia

Contact Info

Product

Resources

About