Antenatally detected solid tumour of kidney

Panda, Shasanka Shekhar; Mandelia, Ankur; Gupta, Devendra K.; Singh, Amit

doi:10.1136/bcr-2013-202084

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Antenatally detected renal tumours are usually associated with the sonographic findings of polyhydramnios and hydrops fetalis, and can present with acute fetal distress. Polyhydramnios is the most common complication,7 and was seen in our case. Hydrops is not commonly described but can occur due to compression of the infra-diaphragmatic vessels, namely the IVC and the ductus venosus.…”

Section: Discussionsupporting

confidence: 59%

The clinical presentation, imaging features and differential diagnoses of congenital Wilms tumour

Rampersad¹,

Diljohn

Goetz

2019

BMJ Case Rep

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Solid fetal renal masses are a rare finding on antenatal ultrasound, with hydronephrosis and cystic disease of the kidney usually being the most common causes for fetal renal enlargement. Herein we report a case of a solid fetal renal mass which was detected on third trimester antenatal ultrasound scanning. This renal mass was evaluated by MRI in the postnatal period and diagnosis confirmed by histological analysis, after surgical excision. Also discussed are the differential diagnoses and imaging features of other solid fetal renal masses, including congenital mesoblastic nephroma, nephroblastomatosis, renal sarcoma and angiomyolipoma.

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Section: Discussionsupporting

confidence: 59%

The clinical presentation, imaging features and differential diagnoses of congenital Wilms tumour

Rampersad¹,

Diljohn

Goetz

2019

BMJ Case Rep

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“…Reports from Leclair et al showed that 39% of fetal renal tumors had polyhydramnios as the main perinatal complication ( 23 ). Other reported complications include hypercalcemia, intra-tumoral hemorrhage, and non-immune hydrops fetalis leading to prematurity, fetal distress, and fetal demise ( 29 ). Our review of the data showed that the survival rate is excellent for infants who had isolated fetal WT, except for one patient who had disease progression secondary to therapeutic delays and suboptimal management leading to death ( 12 ) and another fetus that had several malformations that could be related to a syndrome and can explain the early mortality ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Fetal Wilm's tumor detection preceding the development of isolated lateralized overgrowth of the limb: a case report and review of literature

Bechara,

Saadé,

Geagea

et al. 2024

Front. Pediatr.

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Fetal Wilms tumor (WT) is extremely rare, but with advances in fetal imaging, more cases are being reported. The management of these cases remains challenging. Herein, we present the case of a full-term female infant diagnosed antenatally at 32 weeks of gestation with a right solid renal mass detected on routine prenatal ultrasound without polyhydramnios. At birth, the infant was healthy, with no evidence of dysmorphic features or abnormal laboratory tests to suggest a predisposition syndrome. Her family history was also unremarkable. A successful radical right nephrectomy was performed on day 2 of life revealing a classic WT. She received vincristine as adjuvant chemotherapy without any complications. At the age of 1 month, the infant developed isolated lateralized overgrowth of the right lower limb suspicious of Beckwith–Wiedemann syndrome. At the latest follow-up of 4 years, the child is healthy and disease-free with conserved asymmetry of lower limbs. The case provides insights into the challenging diagnosis and treatment of fetal WT. A review of the literature suggests that the presence of polyhydramnios is a worse prognostic factor while the combination of best supportive care and surgery remains the best management. Fetal WT can be associated with predisposition syndromes; however, their first manifestations can develop after the diagnosis of cancer has been made, as in our patient. We propose starting active surveillance programs and genetic testing for any case of fetal WT.

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