Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study

Fujiwara, Hironobu; Namiki, Chihiro; Hirao, Kazuyuki; Miyata, Jun; Shimizu, Mitsuaki; Fukuyama, Hidenao; Sawamoto, Nobukatsu; Hayashi, Takuji; Murai, Toshiya

doi:10.1016/j.schres.2007.05.044

Cited by 118 publications

(83 citation statements)

References 31 publications

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“…Hubl et al (2004) had reported higher white matter directionality in the temporo-parietal region in auditorily hallucinated patients versus non-auditorily hallucinated controls. Other studies have also reported findings in this direction (Fujiwara et al 2007 ;Seok et al 2007), although they are not directly comparable to ours since all assessed chronically ill patients with persistent symptoms and possibly lengthy exposure to antipsychotics. Our findings are in keeping with those from three recent DTI studies, which have also reported a positive correlation between positive symptoms and FA.…”

Section: Discussioncontrasting

confidence: 70%

Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

et al. 2010

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Background. We investigated cerebral structural connectivity and its relationship to symptoms in never-medicated individuals with first-onset schizophrenia using diffusion tensor imaging (DTI).Method. We recruited subjects with first episode DSM-IV schizophrenia who had never been exposed to antipsychotic medication (n=34) and age-matched healthy volunteers (n=32). All subjects received DTI and structural magnetic resonance imaging scans. Patients' symptoms were assessed on the Positive and Negative Syndrome Scale. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values significantly correlated with symptom scores.Results. In patients with first-episode schizophrenia, positive symptoms correlated positively with FA scores in white matter associated with the right frontal lobe, left anterior cingulate gyrus, left superior temporal gyrus, right middle temporal gyrus, right middle cingulate gyrus, and left cuneus. Importantly, FA in each of these regions was lower in patients than controls, but patients with more positive symptoms had FA values closer to controls. We found no significant correlations between FA and negative symptoms.Conclusions. The newly-diagnosed, neuroleptic-naive patients had lower FA scores in the brain compared with controls. There was positive correlation between FA scores and positive symptoms scores in frontotemporal tracts, including left fronto-occipital fasciculus and left inferior longitudinal fasciculus. This implies that white matter dysintegrity is already present in the pre-treatment phase and that FA is likely to decrease after clinical treatment or symptom remission.

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Section: Discussioncontrasting

confidence: 70%

Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

et al. 2010

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“…46 An asymmetric pattern, with different types in the left and right hemispheres, is common in healthy individuals. 25 On the contrary, there is a lack of such normal ACC asymmetry in patients with schizophrenia [47][48][49][50][51] and in individuals at high risk for schizophrenia. 31,[52][53][54] This observation is line with the hypothesis that anomalies of brain asymmetry are a key feature of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Plaze

Oppenheim

Gaillard

et al. 2017

JPN

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“…The cingulum bundle is the major white matter tract in the cingulate gyrus and carries fibers connecting the parahippocampal gyrus and the orbitofrontal cortex, as well as fibers radiating to the striatum, thalamus, and internal capsule [24,25]. DTI studies have demonstrated decreased anisotropy in the cingulum bundle in schizophrenia [26][27][28][29][30]. Anisotropy changes in men with schizophrenia have been noted in a number of brain areas, including the anterior cingulate gyrus, and were specifically linked to increased impulsivity, a symptom of the disease [11].…”

Section: Introductionmentioning

confidence: 99%

Cingulum bundle white matter in MAG-knockout mice

Segal

Carpenter

Höistad

et al. 2010

Translational Neuroscience

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Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological "Space Balls" method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.

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Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study

Cited by 118 publications

References 31 publications

Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Cingulum bundle white matter in MAG-knockout mice

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