Anterior bilateral uveitis and acute parvovirus B19 infection

Arias-Peso, Borja; Navarro‐Bielsa, Alba; Altabás, María José Vicente; Barón, Nieves Pardiñas

doi:10.1016/j.eimce.2020.11.013

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, Corridan et al [ 18 ] described an 18-year-old girl with bilateral anterior uveitis with ciliary injection, large keratic precipitates occurring predominantly in the corneal periphery, tonic pupils, mild anterior vitritis, and left optic disc hyperaemia. Only 1 case of bilateral anterior uveitis with acute parvovirus infection in a young woman has been reported so far [ 19 ]. Conjunctivitis is another possible ocular manifestation of B19V infection, which has been described concomitantly with the cutaneous lesions, thus suggesting a direct role of the virus in its pathogenesis [ 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Conjunctivitis, Keratitis, and Anterior Uveitis in a Patient Co-infected with Parvovirus B19 and SARS-CoV-2

Saturno¹,

Manni²,

Accorinti³

2022

Case Rep Ophthalmol

View full text Add to dashboard Cite

Parvovirus B-19 (B19V) is a common infection in children, occasionally complicated by ocular manifestations. In patients infected with severe acute respiratory syndrome virus (SARS-CoV-2), many cases of bacterial, fungal, and viral co-infections have been described. We report on a case of bilateral conjunctivitis, keratitis, and anterior uveitis that occurred in a patient co-infected by B19V and SARS-CoV-2. A young nurse developed, 20 days after the onset of asthenia and fever, a maculopapular rash and, in the following month, B19V-related arthritis. Shortly after a course of antibiotics and corticosteroids and the resolution of the arthritis, she began to complain of hearing loss and tinnitus. A polymerase chain reaction for SARS-CoV-2, previously negative, turned out positive; IgM for B19V decreased while IgG increased and antinuclear autoantibody and rheumatoid factor test results were positive. Ear symptoms disappeared after a course of prednisone, but eye burning and itching appeared 2 weeks after the coronavirus disease 2019 (COVID-19) positive swab. Bilateral conjunctivitis, keratitis, and anterior uveitis were diagnosed, which responded completely to a topical corticosteroid and mydriatic therapy. No relapses were observed in the following 12 months. The onset and progression of the symptoms, along with the laboratory findings, suggest a double pathogenesis of the ocular manifestations: keratitis and uveitis, along with the ear symptoms, seem to be the expression of an autoimmune reaction to B19V infection, while the conjunctivitis was likely related to direct infection of the conjunctiva by SARS-CoV-2.

show abstract

Section: Discussionmentioning

confidence: 99%