Anterior capsular contraction after cataract surgery in eyes of diabetic patients

Kato, Satoshi; Oshika, Tetsuro; Numaga, Jiro; Hayashi, Yoshie; Oshiro, Miwako; Yuguchi, Takuma; Kaiya, Tadayoshi

doi:10.1136/bjo.85.1.21

Cited by 62 publications

(34 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because of a small pupil, the capsulorrhexis is inadvertently smaller giving rise to the contracted capsule syndrome, which is particularly common in diabetics. 16 This can not only causes IOL decentration but also hamper the visualisation of the retina, which is a very important examination in diabetics. Most cases of PXF were present in the sixth and seventh decades, and most patients have nuclear sclerosis as well.…”

Section: Discussionmentioning

confidence: 99%

Use of a mydriatic cocktail with a wick for preoperative mydriasis in cataract surgery: a prospective randomised controlled trial

Sengupta

Subramoney

Srinivasan

et al. 2009

Eye

View full text Add to dashboard Cite

Purpose To investigate the efficacy of a standardised wick soaked in a mydriatic cocktail regimen and compare it with the pre-existing regimen of topical dilating drops. Design Prospective, two armed, randomised, double blind, parallel assignment efficacy study Participants In all, 150 eyes of 150 patients were dilated using the dilating cocktail regimen by using a Weck cell sponge. The control group comprised of 75 eyes of 75 patients dilated using the conventional mydriatic regimen. Interventions A specially prepared mydriatic cocktail regimen consisting of 1 : 1 : 1 : 1 ratio of 2.5% phenylephrine, 0.5% moxifloxacin, 1% cyclopentolate, and 0.03% flurbiprofen eye drops was prepared. A standard sized wick (1 cm Â 2 mm) made of Weck cell sponge was soaked in the cocktail for a minute and placed in the lower fornix with sterile forceps. In the control group, eyes were dilated with the above drops using topical instillation in every 15 min. The mydriasis was measured at 15, 30, and 45 min after instillation using the Procyon pupillometer under scotopic conditions (0.04 lux). The intraoperative maintenance of mydriasis was measured with calipers after nucleus delivery and after intraocular lens implantation. Main outcome measures Pupillary diameters at the end of 15, 30, and 45 min, and intraoperative maintenance of mydriasis in the two groups were compared using unpaired t-test.Results There was a statistically significant difference (Po0.001) in dilation achieved at the end of 45 min in both groups. There was also a significant difference of 1-mm dilation between the two groups after nucleus delivery (Po 0.001), and a difference of 1.41 mm after intraocular lens implantation, which was statistically significant (Po0.001).Conclusions These results show that the mydriatic cocktail regimen delivered with a wick is a useful, economical, and timesaving regimen compared with the conventional method of preoperative mydriasis using topical drops.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of a mydriatic cocktail with a wick for preoperative mydriasis in cataract surgery: a prospective randomised controlled trial

Sengupta

Subramoney

Srinivasan

et al. 2009

Eye

View full text Add to dashboard Cite

show abstract

“…Numerous conditions (pseudoexfoliation syndrome, uveitis, advanced age, retinitis pigmentosa, trauma and diabetes mellitus) have been identified as risk factors for ACCS development [8][9][10][11][12][13]. Furthermore, the composition of the IOL implanted is also thought to influence the degree of ACCS; reports demonstrate that ACCS is more extensive in eyes implanted with silicone or hydrogel optic IOL than in eyes implanted with polymethyl methacrylate (PMMA) or acrylic optic IOL [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of anterior capsule contraction between hydrophobic and hydrophilic intraocular lens models

Tsinopoulos

Tsaousis

Kymionis

et al. 2010

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Surgery is the only treatment for diabetic cataract, but after surgery the progression of diabetic retinopathy is often accelerated by the breakdown of the blood-aqueous barrier [1]. Furthermore, anterior capsular contraction [2,3] and posterior capsular opacification [4] are induced earlier in diabetic patients than in non-diabetic patients after cataract surgery and intra-ocular lens implantation. The development of more effective therapies requires a precise understanding of the molecular mechanisms that cause disease, providing a basis for a rational approach to therapy.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of diabetic and galactosaemic cataractous rat lens by microarray analysis

2005

View full text Add to dashboard Cite

Aims/hypothesis: Osmotic and oxidative stress is associated with the progression and advancement of diabetic cataract. In the present study, we used a cDNA microarray method to analyse gene expression patterns in streptozotocininduced diabetic rats and galactose-fed cataractous lenses. In addition, we investigated the regulation and interaction(s) of anti-oxidant protein 2 and lens epithelium-derived growth factor in these models. Methods: To identify differential gene expression patterns, one group of Sprague-Dawley rats was made diabetic with streptozotocin and a second group was made galactosaemic. Total RNA was extracted from the lenses of both groups and their controls. Labelled cDNAwas hybridised to Atlas Rat Arrays. Changes in gene expression level were analysed. Real-time PCR and western analysis were used to validate the microarray results. Results: The expression of 31 genes was significantly modulated in hyperglycaemic lenses compared with galactosaemic lenses. Notably, transcript and protein levels of B-cell leukaemia/ lymphoma protein 2 and nuclear factor-κB were significantly elevated in rat lenses at 4 weeks after injection of streptozotocin. At a later stage, mRNA and protein levels of TGF-β were elevated. However, levels of mRNA for IGF-1, lens epithelium-derived growth factor and anti-oxidant protein 2 were diminished in streptozotocin-induced diabetic cataract. Conclusions/interpretations: These results provide evidence that progression of sugar cataract involves oxidativeand TGF-β-mediated signalling. These pathways may promote abnormal gene expression in the hyperglycaemic and galactosaemic states and thus may contribute to the symptoms associated with these conditions. Since oxidative stress seems to be a major event in cataract formation, supply of anti-oxidant may postpone the progression of such disorders.

show abstract

Anterior capsular contraction after cataract surgery in eyes of diabetic patients

Abstract: Conclusions-Anterior capsular contraction after cataract surgery was greater in eyes of DM patients, especially in those with DR and increased permeability of the blood-aqueous barrier. (Br J Ophthalmol 2001;85:21-23)

Cited by 62 publications

References 14 publications

Use of a mydriatic cocktail with a wick for preoperative mydriasis in cataract surgery: a prospective randomised controlled trial

Use of a mydriatic cocktail with a wick for preoperative mydriasis in cataract surgery: a prospective randomised controlled trial

Comparison of anterior capsule contraction between hydrophobic and hydrophilic intraocular lens models

Gene expression profiling of diabetic and galactosaemic cataractous rat lens by microarray analysis

Contact Info

Product

Resources

About