The basic anatomy of the human spine is described to highlight the interaction among spinal components that provides the desired function in a normal person. The factors that lead to instability–abnormal motion are described. Abnormal motion may be due to external environmental factors to which the spine is subjected to during activities of daily living (e.g., impact, repetitive loading, lifting) degeneration, infectious diseases, injury or trauma, disorders, and/or surgery. The biomechanics encompasses the mechanical aspects of conservative treatments, surgical procedures and spinal stabilization techniques. These issues are narrated in this article. However, the field of spinal biomechanics is very broad and it is not practical to cover all aspects in one article. For example, this article does not deal with whiplash mechanisms, impact loads, injury biomechnaics due to falls, and in sports to name a few.