Anterior Chamber Aqueous Flare Is a Strong Predictor for Proliferative Vitreoretinopathy in Patients With Rhegmatogenous Retinal Detachment

Schröder, Sabine; Muether, Philipp S.; Caramoy, Albert; Hahn, Moritz; Abdel-Salam, M.; Diestelhorst, Michael; Kirchhof, Bernd; Fauser, Sascha

doi:10.1097/iae.0b013e3182173753

Cited by 47 publications

(58 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Laser flare photometry is a potent tool to estimate preoperatively the individual risk of patients with RD to develop PVR in the later course after initially successful re-attachment surgery 3. In the present study we confirmed these previous results in an independent cohort.…”

Section: Discussionsupporting

confidence: 90%

“…Exclusion criteria included active vasculitis, active uveitis, proliferative diabetic retinopathy, diabetic macular oedema, neovascular age-related macular degeneration, retinal vein occlusion and preoperative PVR grade C. All patients were enrolled for the study. There was no overlap with the previously reported cohort 3. All surgery was performed by one of four experienced vitreoretinal surgeons, who were aware of flare values preoperatively.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, the sensitivity and specificity of preoperative flare at different cut-off values were too low to adequately filter out the high-risk patients. As a consequence, we were unable to validate the findings of Schroder et al ,13 although they used the same flare metre type and calibration protocol.…”

Section: Discussionmentioning

confidence: 75%

“…A different potential predictor for PVR development was found by Schroder et al 13. They found preoperative anterior chamber flare—caused by reflection of laser light by proteins in aqueous humour—to be a strong predictor for PVR development.…”

Section: Introductionmentioning

confidence: 86%

Preoperative aqueous humour flare values do not predict proliferative vitreoretinopathy in patients with rhegmatogenous retinal detachment

Mulder¹,

Tode²,

Dijk³

et al. 2017

Br J Ophthalmol

View full text Add to dashboard Cite

Background/aims Patients with rhegmatogenous retinal detachment (RRD) who develop postoperative proliferative vitreoretinopathy (PVR) have been found to have higher preoperative laser flare values than patients with RRD who do not develop this complication. Measurement of laser flare has therefore been proposed as an objective, rapid and non-invasive method for identifying high-risk patients. The purpose of our study was to validate the use of preoperative flare values as a predictor of PVR risk in two additional patient cohorts, and to confirm the sensitivity and specificity of this method for identifying high-risk patients. Methods We combined data from two independent prospective studies: centre 1 (120 patients) and centre 2 (194 patients). Preoperative aqueous humour flare was measured with a Kowa FM-500 Laser Flare Meter. PVR was defined as redetachment due to the formation of traction membranes that required reoperation within 6 months of initial surgery. Logistic regression and receiver operating characteristic analysis determined whether higher preoperative flare values were associated with an increased risk of postoperative PVR. Results PVR redetachment developed in 21/314 patients (6.7%). Median flare values differed significantly between centres, therefore analyses were done separately. Logistic regression showed a small but statistically significant increase in odds with increasing flare only for centre 2 (OR 1.014; p=0.005). Areas under the receiver operating characteristic showed low sensitivity and specificity: centre 1, 0.634 (95% CI 0.440 to 0.829) and centre 2, 0.731 (95% CI 0.598 to 0.865). Conclusions Preoperative laser flare measurements are inaccurate in discriminating between those patients with RRD at high and low risk of developing PVR.

show abstract

“…Instead of conventional slit-lamp microscopy, the LFCM provides an accurate and reproducible method for evaluating BAB dysfunction [5]. Numerous studies have quantified BAB breakdown in patients with uveitis and acute angle-closure glaucoma and in patients after cataract surgery, penetrating keratoplasty, and panretinal photocoagulation [6,7,8,9,10,11,12,13,14]. However, to the best of our knowledge, few studies so far have reported breakdown of the BAB after ocular trauma.…”

Section: Discussionmentioning

confidence: 99%

Damage to the Blood-Aqueous Barrier in Ocular Blunt Trauma and Its Association with Intraocular Pressure Elevation

et al. 2016

View full text Add to dashboard Cite

Background: The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. Methods: This is a prospective case-control study, and the following 3 groups were included: elevated IOP (45 patients with an elevated IOP secondary to ocular blunt trauma), normal IOP (27 patients with a normal IOP after ocular blunt trauma), and healthy controls. The main outcome measures were IOP and BAB function evaluated using a laser flare-cell meter (LFCM). Results: Patients had significantly higher flare intensities and cell counts than the normal controls (both p < 0.001), and the elevated-IOP group displayed even higher LFCM readings than the normal-IOP group. Aqueous flare and cell readings were positively correlated with IOP (r = 0.529 and 0.590, respectively, p < 0.001). LFCM readings in the elevated-IOP group were still significantly high even on postraumatic day 120 following anti-inflammatory treatment. Conclusion: BAB dysfunction occurred following ocular blunt trauma. Eyes with an elevated IOP displayed a more seriously disturbed BAB and a longer recovery course. Examination with a LFCM provides insight into the pathophysiology of IOP elevation and assists in making decisions concerning anti-inflammatory treatment during follow-up.

show abstract

Anterior Chamber Aqueous Flare Is a Strong Predictor for Proliferative Vitreoretinopathy in Patients With Rhegmatogenous Retinal Detachment

Cited by 47 publications

References 9 publications

Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment

Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment

Preoperative aqueous humour flare values do not predict proliferative vitreoretinopathy in patients with rhegmatogenous retinal detachment

Damage to the Blood-Aqueous Barrier in Ocular Blunt Trauma and Its Association with Intraocular Pressure Elevation

Contact Info

Product

Resources

About