Anterior chamber interleukin 1β, interleukin 6 and prostaglandin E₂in patients undergoing femtosecond laser-assisted cataract surgery

Abstract

Inflammatory cytokines IL-1β, IL-6 and PGE2 significantly increased after femtosecond laser-assisted cataract surgery, which maybe the cause of intraoperative miosis seen in these patients.

Concentrations of matrix metalloproteinase-2 and interleukin-1 β in the aqueous humor of dogs with normal and cataractous eyes

“…However, the concentration IL-1 β increased significantly in accordance with the degree of lens opacification. Contrary to our findings, it has been reported that the concentration of IL-1 β in the aqueous humor of humans with cataracts at stage II and III did not differ significantly; however, patients of that study received anti-inflammatory eye drops before phacoemulsification (Wang et al 2016). Chiou et al (1994) observed that the intraocular inflammation induced by lens proteins can be prevented with the use of interleukin-1 blockers; our results are consistent with these findings.…”

“…Both IL-1 α and β are predominantly secreted by activated macrophages, B lymphocytes, and endothelial cells (Chiou et al 1994, Medeiros et al 2008, Ortencio et al 2015. In animals and humans, IL-1 β seems to play a role in the pathogenesis of uveitis (Chiou et al 1994, Nishi et al 1994, El-Shabrawiet al 2000, Medeiros et al 2008, Ortencio et al 2015, Wang et al 2016, Aketa et al 2017. One study demonstrated that the concentration of IL-1 β in the aqueous humor is correlated with the degree of iris damage in human patients who have undergone laser iridotomies and intraocular surgical procedures (Aketa et al 2017).…”

“…One study demonstrated that the concentration of IL-1 β in the aqueous humor is correlated with the degree of iris damage in human patients who have undergone laser iridotomies and intraocular surgical procedures (Aketa et al 2017). Another study reported that the concentration of IL-1 β in the aqueous humor was significantly increased in humans who have undergone femtosecond laser assisted cataract surgery, in comparison with the ones operated without laser assistance (Wang et al 2016). With regard to veterinary ophthalmology, no studies have focused on quantifying the level of this cytokine in the aqueous humor of dogs with uveitis.…”

Acute clouding of trifocal lens during implantation: a case report

“…Femtosecond laser technology has the ability to facilitate and optimize manual portions of cataract surgery [ 10 – 12 ]. Zhang S [ 13 ] reported that inflammatory cytokines IL-1β, IL-6, and PGE2 significantly increased after femtosecond laser-assisted cataract surgery. However, to the best of our knowledge, there was no report about IOL opacification caused by femtosecond laser and correlative inflammatory cytokines.…”

The use of cytokines in the treatment of cornea inflammatory and dystrophic diseases (review)

“…В свою очередь иммунохимические методы позволяют измерить концентрацию цитокинов в тканях и жидкостях глаза. Основным субстратом для проведения исследования служат слеза, влага передней камеры, стекловидное тело [16,17]. Метод иммуноферментного анализа для определения содержания цитокинов в настоящее время набирает все большую популярность.…”