Anterior chest wall giant cell tumor

Dehghan, Arash; Moaddab, Amirhossein; Eskandarlou, Mahdi; Moeeni, Abbas

doi:10.1007/s11748-009-0463-8

Cited by 12 publications

(12 citation statements)

References 6 publications

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“…This delayed presentation probably contributed to the extremely large tumor size found at the time of surgical resection. While multiple cases of GCT originating from the rib have been reported, the two-dimensional span of 28.0 × 24.0 cm resected in our patient appears to be the largest to date (Table 1) [4, 8–14]. …”

Section: Discussionmentioning

confidence: 87%

“…Giant cell tumors of the bone account for 5% of all primary bone tumors [4]. Most (85%) occur in the long bones, and approximately 50% are found around the knee joint.…”

Section: Discussionmentioning

confidence: 99%

“…Excision is desirable as 10% of GCTs in ribs undergo malignant transformation [7], while radiation therapy is not recommended as most of malignant transformations are related to previous radiation therapy [4]. Thus en bloc excision is an appropriate treatment, and disease-free survival is directly proportional to negative resection margin [15].…”

Section: Discussionmentioning

confidence: 99%

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Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

Sharma

Armstrong

2012

Case Reports in Medicine

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Introduction. Giant cell tumor of the bone is a rare benign lesion that infrequently affects the ribs, and if present, is usually located posteriorly. The rarity of this tumor poses diagnostic and therapeutic problems for physicians, especially when it is located in the anterior arc of the rib in close proximity to the breasts in female patients. Case Presentation. We report the case of a 32-year-old Asian female with a giant cell tumor of her anterior rib, presenting as a large inframammary mass. Computed tomography showed a tumor arising from the 7th rib anteriorly with marginal sclerosis, cortical destruction, and a soft tissue mass. She was treated with surgical resection, and the defect was reconstructed primarily. The surgical specimen measured 28.0 × 24.0 cm. The microscopic examination showed a large number of multinucleate giant cells scattered over the parenchyma. Patient recovered uneventfully and continues to be recurrence-free six years after surgical resection. Conclusion. We report the largest known case of giant cell tumor arising from the anterior aspect of a rib. We recommend including giant cell tumor in the differential diagnosis of chest wall masses especially in female patients, regardless of the size on clinical examination.

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Section: Discussionmentioning

confidence: 87%

“…Giant cell tumors of the bone account for 5% of all primary bone tumors [4]. Most (85%) occur in the long bones, and approximately 50% are found around the knee joint.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

Sharma

Armstrong

2012

Case Reports in Medicine

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“…The lower end of the femur is the favoured location. The costal involvement represents less than 1% of the cases [1,2] and most often occurs at the epiphysis of the head and tubercle [3]. The anterior chest wall is rarely involved [4].…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of a Rare Tumor of the Chest Wall : Giant Cell Tumor of Bone

Baiz¹,

Afandi

Fenane

et al. 2019

Integr J Med Sci

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Introduction: Giant cell tumours account 5% of all bone tumours. However, the anterior chest wall is rarely involved .Clinical case: This is a 68-year-old housewife who has been thyroidectomized, for 11 years and is under hormone replacement therapy, and hysterectomized for 6 years after a uterine tumor. She is present for the onset of a 5 month old hard submammary mass on the left associated with left anterior chest pain under mammals. The clinical examination had found an irregular hard mass under left mammary which is fixed to the anterior arch of the 4th left rib. A thoracic x-ray showed a limited left hilo-axillary with an homogenously dense opacity. The thoracic CT scan showed the presence of a thoracic parietal mass of osteolytic tissue density centered on the anterior arch of the 4th left rib; without contrast agent, the surgical exploration through thoracotomy revealed a thoracic parietal tumoral process at the expense of the anterior arch of the 4th limb pushing the corresponding lung inwards. Surgical excision allowed ablation of the whole tumor in monobloc towards a healthy zone. The anatomopathological study of the operative specimen showed a morphological and histopathological aspect compatible with a costal tumor with giant cells. The postoperative recovery was marked by a good clinical and radiological improvement. The last check up after the surgery revealed that the patient was still asymptomatic. Good clinical, biological and radiological improvement was noted with a decline of 8 months.Conclusion: Giant cell tumors are aggressive bone tumors, yet histologically benign. The chosen examination is a thoracic CT scan with surgical treatment. A clinical and radiological monitoring is necessary. The recurrence is rare, but it usually necessitates a second surgery. The objective of this clinical observation is to highlight the possibility, although rare, of a giant cell tumor in case of the swelling of the soft parts, and a lytic lesion of the anterior part of a rib. Therefore, this tumor must be added to the list of diagnoses to be mentioned in this situation.

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“…Till now the largest been reported is 25× 15 cm [1,2] making it the second largest been reported so far.…”

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confidence: 98%

Rare Gigantic Giant Cell Tumor of Anterior Ribs in a Young Lady

Kalra

Agarwal²

2014

Indian J Surg Oncol

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Any mass arising from the breast region need not to be breast carcinoma! A rapidly growing mass from the chest wall need not to be highly malignant! The present case report defines the thin line between the two extremes and high lightens the importance of a good clinical examination followed by a judicial management. The lady in question had a huge Giant cell tumor in the Anterior arc of ribs which is quite rare, making it the second largest tumor been reported so far and the largest in Asia. The patient was referred to us by the Department of Thoracic Surgery in view of the aggressive nature of the lesion and the requirement of a major reconstructive surgery for the chest wall. The reconstructive procedure chosen was time tested and not new yet not so popular in the present time. It could cover such a huge chest wall defect with minimum morbidity and good results.Keywords Breast . Giant cell tumor . Anterior ribs Twenty-three year old lady presented with left chest wall mass from past 1 year, rapidly enlarging since 5 months. She had complains of heaviness in chest associated with pain radiating to left shoulder and arm with no features suggestive of systemic disease. On local examination, solitary chest wall mass was present on left side 14×12 cm extending 1 cm from clavicle inferiorly in vertical direction and from left border of sternum in horizontal direction displacing the breast tissue inferolaterally. There was no visible pulsations and no impulse on cough. On palpation, it was non tender, uniformly hard in consistency with mild local rise in temperature. The overlying skin was pinchable and dilated veins were present over the mass. The mass was fixed with the chest wall. On pectoral contraction, the mass appeared less prominent. On systemic examination, breath sounds were decreased on left side with cardia displaced to right (Fig. 1).Diagnosis was made of Chondrosarcoma, Malignant Fibrous Histiocytoma and Pulmonary tumor with Rib metastasis. CT thorax showed 10×8×8.5 cm large mass lesion from chest wall which showed heterogenous enhancement extending into the intrathoracic region with erosion of left second rib. The lesion was compressing the mediastinum with clear fat planes. No significant hilar or mediastinal lymphandenopathy was seen (Fig. 1). FNAC of the mass was suggestive of chondrosarcoma. After investigations, patient was planned for wide local excision with concurrent reconstruction of the chest wall.Under anaesthesia, left inframammary incision was given which was deepened to sub pectoral space. The whole breast tissue was reflected up with the pectorals to inspect the tumor. It was seen invading the chest wall, so approach was made in infero-lateral direction. Ribs were cut to explore its extent and its involvement with mediastinal structures. There was a clear plane which was further accentuated between the mass and lung. More than 2/3rd of the left pleural cavity was found to be occupied by the tumor. Cardia was pushed to right and left lung was found to be collapsed but uninvolve...

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Anterior chest wall giant cell tumor

Cited by 12 publications

References 6 publications

Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

Unusual Presentation of a Rare Tumor of the Chest Wall : Giant Cell Tumor of Bone

Rare Gigantic Giant Cell Tumor of Anterior Ribs in a Young Lady

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