Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates

Monosov, Ilya E.; Haber, Suzanne N.; Leuthardt, Eric C.; Jezzini, Ahmad

doi:10.1016/j.cub.2020.10.009

Cited by 76 publications

(40 citation statements)

References 139 publications

(219 reference statements)

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“…On the other hand, previous studies have shown that the association between Theta activity in ACC and response time in the planning period may reflect the high cognitive demands associated with this task (Domic-Siede et al, 2021 ). Research supports that the anterior cingulate gyrus is well-suited to regulate behavioral selection and learning on multiple time scales, and to respond differently to environmental uncertainty and volatility (Monosov et al, 2020 ). Furthermore, increased ACC functional connectivity may be the result of making up for decreased PCC activity, thus maintaining relatively normal ability of daily living.…”

Section: Discussionmentioning

confidence: 99%

Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation

Yuan

Xue

et al. 2021

Front. Aging Neurosci.

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Background: Mild cognitive impairment (MCI) represents a transitional state between normal aging and dementia disorders, especially Alzheimer's disease (AD). The disruption of the default mode network (DMN) is often considered to be a potential biomarker for the progression from MCI to AD. The purpose of this study was to assess MRI-specific changes of DMN in MCI patients by elucidating the convergence of brain regions with abnormal DMN function.Methods: We systematically searched PubMed, Ovid, and Web of science for relevant articles. We identified neuroimaging studies by using amplitude of low frequency fluctuation /fractional amplitude of low frequency fluctuation (ALFF/fALFF), regional homogeneity (ReHo), and functional connectivity (FC) in MCI patients. Based on the activation likelihood estimation (ALE) algorithm, we carried out connectivity modeling of coordination-based meta-analysis and functional meta-analysis.Results: In total, this meta-analysis includes 39 articles on functional neuroimaging studies. Using computer software analysis, we discovered that DMN changes in patients with MCI mainly occur in bilateral inferior frontal lobe, right medial frontal lobe, left inferior parietal lobe, bilateral precuneus, bilateral temporal lobe, and parahippocampal gyrus (PHG).Conclusions: Herein, we confirmed the presence of DMN-specific damage in MCI, which is helpful in revealing pathology of MCI and further explore mechanisms of conversion from MCI to AD. Therefore, we provide a new specific target and direction for delaying conversion from MCI to AD.

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Section: Discussionmentioning

confidence: 99%

Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation

Yuan

Xue

et al. 2021

Front. Aging Neurosci.

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“…One possibility is that distinct neural patterns or voxel clusters within dACC may distinctly encode positive outcomes (e.g., monetary rewards, juice) and negative outcomes (e.g., punishments, saltwater). Such patterns seem plausible, given recent work demonstrating that dACC neurons respond to rewards and punishments in nonhuman primates (Monosov, 2017;Monosov et al, 2020) and rodents (Schneider et al, 2020). Alternatively, dACC voxels may be multiplexed to encode both positive and negative outcomes, or even contextspecific incentives and actions (Hayden & Platt, 2010).…”

Section: Discussionmentioning

confidence: 99%

Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance

et al. 2021

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B. and subaward R24-AG054355 D.M.Y.) and McDonnell Center for Systems Neuroscience (T.S.B. and D.M.Y.). D.M.Y. and J.L.C. were supported by T32-AG000030, and D.M.Y.was additionally supported by F31-DA042574 and T32-NS073547. We would like to thank Carolyn Dean Wolf, and Katherine Shapiro for their assistance with data collection and technical support. We also thank Amitai Shenhav, Katherine Conen, as well as the CCP and Shenhav labs for helpful input and discussions during manuscript preparation.

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“…In macaque monkeys and humans, ACC and MCC contain premotor fields (cingulate motor areas/zones), with both output to and input from motoneurons in the spinal cord, well-situated for a role in action selection and control (Dum et al, 2009; Dum & Strick, 1996; Koski & Paus, 2000; Matelli et al, 1991; Monosov et al, 2020; Petrides & Pandya, 2006; Picard & Strick, 1996; Ruehl et al, 2021; Sewards & Sewards, 2003; Shyu et al, 2010; Vogt & Vogt, 2003). The organization of cingulate cortex, including the midcingulate zones, has been called “actotopic” (Caruana et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Prediction and action in cortical pain processing

Koppel

Novembre

Kämpe

et al. 2021

Preprint

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Predicting that a stimulus is painful facilitates action to avoid harm. But does the prediction of upcoming painful events engage the same or different processes than acting to avoid or reduce current pain? In this fMRI experiment, we investigated brain activity as a function of current and predicted painful or nonpainful thermal stimulation, and the ability of voluntary action to affect the duration of the upcoming stimulation. Participants (n = 30) performed a task which involved the administration of a painful or nonpainful stimulus (S1), which predicted an immediately subsequent very painful or nonpainful stimulus (S2). Participants' task was to press a response button within a short time window upon the presentation of a response cue during S1. On action-effective trials, pressing the button within the specified time window reduced the duration of the upcoming stimulation. On action-ineffective trials, pressing the button had no effect on upcoming stimulation. Predicted pain increased activation in regions including anterior cingulate cortex (ACC), midcingulate cortex (MCC), and insula; however, activation in ACC and MCC depended on whether a meaningful action was performed, with MCC activation showing a direct relationship with motor output. Region-of-interest analyses revealed that insula's responses for predicted pain were also modulated by potential action consequences, especially in the left hemisphere, albeit without a direct relationship with motor output. Taken together, these findings suggest that cortical pain processing is not specifically tied to the sensory stimulus, but instead depends on the consequences of that stimulus for sensorimotor control of behavior.

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Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates

Cited by 76 publications

References 139 publications

Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation

Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation

Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance

Prediction and action in cortical pain processing

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